Sodium chloroacetate

Structural formula
General
Surname	Sodium chloroacetate
other names	NaTa Na-MCA Sodium monochloroacetate
Molecular formula	C 2 H 2 ClNaO 2
Brief description	hygroscopic, flammable, white powder
External identifiers / databases
CAS number 3926-62-3 EC number 223-498-3 ECHA InfoCard 100,021,363 PubChem 23665759 Wikidata Q410825
properties
Molar mass	116.48 g mol −1
Physical state	firmly
density	1.71 g cm −3
Melting point	> 150 ° C (slow decomposition)
solubility	good in water (820 g l −1 at 20 ° C)
safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary danger H and P phrases H: 301-315-400 P: 273-280-301 + 310-332 + 313
Toxicological data	95 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sodium chloroacetate is a chemical compound . It is the sodium salt of chloroacetic acid , which is used as a starting material or intermediate in the manufacture of a large number of chemicals , such as pharmaceuticals and plastics .

Extraction and presentation

Sodium chloroacetate is produced industrially by reacting monochloroacetic acid with soda .

${\displaystyle \mathrm {2\ CH_{2}ClCOOH+Na_{2}CO_{3}\longrightarrow 2\ CH_{2}ClCOONa+\ H_{2}O+\ CO_{2}\uparrow } }$

properties

Sodium chloroacetate is a flammable, white solid that is easily soluble in water. It decomposes above 150 ° C, producing carbon monoxide , carbon dioxide , hydrogen chloride and sodium oxide .

use

Sodium chloroacetate is used as a raw material for the production of pharmaceuticals, plastics and dyes, cosmetics , herbicides , carboxymethyl cellulose , thioglycolic acid , glycine and nitromethane .

safety instructions

When burning or heating sodium chloroacetate, caustic hydrogen chloride is produced .

literature

• GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA) (Ed.): Trichloroacetic acid CAS-No. 76-03-9, Sodium Trichloroacetate CAS-No. 650-51-1 . Hirzel, 1997, ISBN 978-3-7776-0765-8

Individual evidence

1. ↑ ^{a b} Data sheet sodium chloroacetate (PDF) from Merck , accessed on January 18, 2011.
2. ↑ ^{a b} Cordula Christine Günter: Sodium salt of monochloroacetic acid: effect on kidney cells in humans with special consideration of cathepsin activities , dissertation, University of Tübingen, 2004. ( PDF , 668 kB).
3. ↑ ^{a b c d e} Entry on sodium chloroacetate in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
4. ↑ Entry on sodium chloroacetate in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers and / or distributors can expand the harmonized classification and labeling .
5. ↑ OECD : Screening Information Dataset (SIDS) Initial Assessment Report (SIAR) for Sodium chloroacetate , accessed on November 3, 2014.