Octoxinol 9

Structural formula
	n = 9 to 10
General
Surname	Octoxinol 9
other names	Octoxynol 9; ( p - tert- octylphenoxy) polyethoxyethanol; O - [4- (1,1,3,3-tetramethylbutyl) phenoxy] polyethoxyethanol; Polyethylene glycol [4- (1,1,3,3-tetramethylbutyl) phenyl] ether;
Molecular formula	C 14 H 22 O (C 2 H 4 O) n with n = 9-10
Brief description	colorless to yellowish liquid
External identifiers / databases
EC number	618-344-0
ECHA InfoCard	100.123.919
Wikidata	Q421654
properties
Molar mass	≈ 625 g · mol -1
Physical state	liquid
density	1.07 g cm −3
Melting point	6 ° C
boiling point	> 200 ° C
Vapor pressure	<1 Pa (20 ° C)
solubility	soluble in water
safety instructions
H and P phrases	H: 302-318-411
	P: 273-280-305 + 351 + 338
Toxicological data	1900 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Octoxinol 9 ( INN ) is a p - tert- octylphenol - derivative with a polyethylene glycol side chain of 9 to 10 ethylene oxide units. It is a nonionic surfactant from the group of octylphenol ethoxylates. Brand names from this series include Triton X-100 and Nonidet P40.

properties

Octoxinol 9 can change the melting behavior of DNA double strands. Due to its aromatic structure, it absorbs UV light and can falsify the result in photometric determinations using UV light.

use

Octoxinol 9 is used as a detergent in biochemistry . Since there proteins as opposed to SDS not denatured , it is in the protein purification used to membrane proteins in their native conformation of membrane extract. It is also used for virus inactivation of enveloped viruses by the solvent-detergent process .

Octoxinol 9 is used as a replacement substance for the spermicide Nonoxinol 9 and as a pharmaceutical excipient.

Individual evidence

↑ ^a ^b ^c ^d ^e ^f Datasheet Octoxinol 9 (PDF) from Merck , accessed on January 19, 2011.
↑ ^a ^b ^c Data sheet Triton ^® X-100 from Sigma-Aldrich , accessed on November 29, 2012 ( PDF ).
↑ Entry on Octoxinol 9 in the ChemIDplus database of the United States National Library of Medicine (NLM) .
↑ dow.com: TRITON ™ X-100 Surfactant (Technical Data Sheet).
↑ Helenius, A. & Simons, K. (1975): Solubilization of membranes by detergents. In: Biochim. Biophys. Acta . Vol. 415, pp. 29-79 ( PMID 1091302 ; doi : 10.1016 / 0304-4157 (75) 90016-7 ).
↑ Calbiochem Booklet: Detergents (PDF; 619 kB).
↑ octoxynol 9 Vaginal consumer information from Drugs.com .

[Merck-1] ↑ ^a ^b ^c ^d ^e ^f Datasheet Octoxinol 9 (PDF) from Merck , accessed on January 19, 2011.

[Sigma-2] Data sheet Triton ^® X-100 from Sigma-Aldrich , accessed on November 29, 2012 ( PDF ).

[ChemIDplus-3] Entry on Octoxinol 9 in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[4] w.com: TRITON ™ X-100 Surfactant (Technical Data Sheet).

[5] Helenius, A. & Simons, K. (1975): Solubilization of membranes by detergents. In: Biochim. Biophys. Acta . Vol. 415, pp. 29-79 ( PMID 1091302 ; doi : 10.1016 / 0304-4157 (75) 90016-7 ).

[6] Calbiochem Booklet: Detergents (PDF; 619 kB).

[7] toxynol 9 Vaginal consumer information from Drugs.com .