Paolo Brenner

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Paolo Brenner (2013)

Paolo Brenner (born May 21, 1966 in Höchstädt an der Donau ) is a German specialist and professor for cardiac surgery at the Cardiac Surgery Clinic at the Großhadern Clinic of the LMU Munich . He is known for his work in the field of xenotransplantation , the further development of artificial hearts , extracorporeal membrane oxygenation (ECMO) and lung transplantation .

Life

Even as a teenager, Brenner became involved as a founding member of the German Society for Cosmology (DGK), was editor and co-editor of the Zeitschrift für Kosmologie from 1990 to 2007, in which he was driven by a 95-page physical work (1985) on the subject of the life story of Fixed stars and a youth research work on black holes 1986 published numerous own publications and overviews on cosmological topics.

Brenner did his Abitur in 1985 in Donauwörth and studied medicine at the LMU Munich from 1986 to 1993. During his medical studies he received a scholarship from the Konrad-Adenauer-Stiftung and was the scholarship spokesperson for the foundation in Munich for several years. After completing his medical training, he worked as an intern in the cardiac surgery clinic / Klinikum Großhadern in Bruno Reichart's team from 1993 . In 1996 and 1997, Brenner narrowly dropped out of the last 20 applicants for a cosmonaut training program in Star City ( Swjosdny Gorodok ) in Russia in a national (15,000 applicants) and international (150,000 applicants) final selection and is now a member of the Association for the Promotion of Space Travel . From 1995 to 1997 he worked as a scientific assistant at the Cardiac Surgery Clinic and Polyclinic, Großhadern Clinic of the LMU Munich and was approved as a study director for clinical, pharmacological studies. In 1995 he was awarded a magna cum laude Dr. med. PhD. His dissertation topic was: Effect of different peptides on the sympathetic system of Brown Norway rats before and after inhibition of the conversion enzyme . The dissertation was instrumental in the development of the drug Ramipril . In 1997 he received a habilitation grant from the Bavarian Research Foundation for the project development of genetic engineering and mechanical processes for the implementation of xenogenic transplantation of pig organs at the Institute for Surgical Research. As part of this project, he carried out various xenoperfusion and transplanation test series of landrace and transgenic pig hearts. In 1999, Brenner moved to the Cardiac Clinic at the Augustinum as a scientific assistant at the LMU Cardiac Surgery Clinic in Bruno Reichart's team . In 2003 he completed his specialist training in cardiac surgery. He continued to work on the xenotransplant follow-up project Production of multi-transgenic pigs and the development of immunomodulatory strategies for clinical xenotransplantation . In the same year he moved to the Grosshadern Clinic of the LMU as a surgeon within the Cardiac Surgery Clinic. 2004 followed the completion of habilitation with the teaching qualification for the subject cardiac surgery with the Habilitation Topic: Influence of immunoadsorption on xenogeneic rejection mechanisms in perfusion and in xenotransplantation of Landrace and hDAF transgenic pig hearts in primates , which was written down in a 1450-page work. In 2004 he was appointed private lecturer and at the same time senior physician at the cardiac surgery clinic, in 2006 senior physician at the cardiac surgery clinic and member of the Munich Lung Transplant Group (ex- and implantation). In 2011, Brenner was appointed adjunct professor at LMU and in 2012 promoted to the rank of Academic Director as a civil servant.

Paolo Brenner has been a founding member and current member of the foundation board of the Christian Development Service Foundation since 1992, together with Susanne Pechel, and worked for Mother Teresa in 1997 in Calcutta .

Scientific contribution

Since 1993, Mr. Brenner has dealt with issues of thoracic organ transplantation (from 2004 as transplant surgeon of the heart and lungs ), since 2006 as a member of the Munich Lung Transplant Group and since 2000 as explorer of the German Foundation for Organ Transplantation (DSO). He was already active as a junior operator for the then Baxter Novacor company for the portable artificial heart system Novacor and is most recently researching the development of miniaturized " valve turbine pumps" as a proctor for JarvikHeart in cooperation with Robert Jarvik . With the support of the Bavarian Research Foundation , the specialist in cardiac surgery and his research team have been working with his research team since 1997 on the xenogenic transmission of multitransgenic pig hearts as a future organ replacement in humans, from 2004 within the framework of the transregional research group FOR 535 of the DFG and from 2012 as PI for the xenogenic area Heart transplantation in the Transregio Collaborative Research Center 127 (SFB127) with the speaker Bruno Reichart at the Walter Brendel Center for Surgical Research.

Cardiac xenotransplantation (from pig to human), on which Brenner and Reichart have been researching since 1997, has already reached the preclinical stage despite the higher immunological complexity due to pre-existing and newly formed antibodies in whole organs. In a patented combination (EP 1181034 B1, EP 1980263A1, US 8435520 B2) of transgenic organ / cells and immune adsorption (filtering out antibodies from the recipient) and special immunosuppressant combinations, hyperacute and delayed rejection are to be prevented and xenograft survival is made possible. This makes xenotransplantation extremely interesting in times of massive, increasing organ shortages and still major problems with artificial hearts (cable connections, batteries, strokes, infections) in the area of ​​organ / cell transplantation, as the almost unlimited supply of porcine organs (heart, kidney, lungs, Cornea, (liver rather unlikely)) and cells (pig islet cells in diabetes, nigrostriatal brain cells against Parkinson's disease , cornea of ​​the eye, stem cells, bone / marrow, skin, etc.) not only in Europe, but also many people worldwide animal cells or an organ replacement could be helped.

With 45 original publications, over 110 national and international lectures, two highly endowed international research awards and as a supervisor of over 20 postdocs and doctoral students (e.g.) in several working groups, Brenner has made a significant contribution to the scientific progress of the LMU, primarily through his highly specialized detailed knowledge of xenotransplantation and mechanical circulatory support systems. He was therefore appointed adjunct professor in 2011. Brenner is an international expert in mechanical and "biological" heart substitutes, for which he also has patents (e.g.). In his teaching activity, Brenner has been involved in the introduction of the practice-oriented MECUM training system at the LMU, which is based on the Harvard University concept, from 2007 onwards, he was a lecturer for cardiac surgery at the LMU and from 2011 he was deputy block spokesman for the cardiovascular block in the LMU's new medical student training system, Modul23 . Since 2003, as the head of cardiac surgery training, he has organized around 400 professional and scientific training events, mostly as Monday training courses for specialist training and further education certified by the Bavarian State Medical Association.

More recent research focuses and interests Brenners are miniature artificial hearts in heart valves (cooperation with Robert Jarvik ), inhibition of aging enzymes, cryonics , energy and environmental technology (e.g. electromobility ), essential oils and Ebola .

Awards

  • “Young Investigator's Award of the European Association for Cardio-Thoracic Surgery” for the work The influence of antibody and complement removal with a Ig-Therasorb column in a xenogeneic working heart model (Brussels, 20-23 September 1998, 12th Ann. Meeting of the EACTS)
  • "Biotest Award from the European Society for Organ Transplantation" for the work Influence of Ischemic Time on Hyperacute Xenograft Rejection of pig hearts in a working heart perfusion model with human blood (Oslo, June 24, 1999, 9th Congress of the European Society for Organ Transplant (ESOT)

Memberships in scientific associations

Medical Associations :

  • Transplantation Society (TTS),
  • International Xenotransplantation Association (IXA)
  • Senior Scientist / Principal Investigator (PI) of the Collaborative Research Center Transregio-SFB 127 Xenotransplantation of the German Research Foundation (DFG) on the subject of biology of xenogenic cell and organ transplantation .
  • Member of the German Society for Thoracic, Cardiac and Vascular Surgery
  • Member of the Advisory Board of Immunapheresis in Solid Organ Transplantation
  • Explanteur of the DSO
  • Proctor of the artificial heart company JarvikheartTM (New York, USA)
  • Member of the Board of Trustees of the Christian Development Service (CED)

Other scientific associations

  • Co-founder of the German Society for Cosmology (1986 to 2007)

Editorial boards and reviewers

Medical journals :

  • International Journal of artificial organs (IJAO)
  • German Research Foundation
  • Xenotransplantation

Other journals :

  • Editor of the Zeitschrift für Kosmologie (1986 to 2008),

Patents: International patents and US patent

  • Publication of the international patent with the title: "Combinations of immunosuppressive agents for the treatment or prevention of graft rejection" / "Organic Compounds" (International Application Number: PCT / EP00 / 04250 and International Publication Number WO 00/67773 A3, filing number 00927193.3 ), granted on July 21, 2010 as European patent with the number 1181034.
  • US patent "Combination of immunosuppressive agents for the treatment or prevention of graft rejection" (US 2002/0132764 A1, filing number 11/599814), 3/2013 issued as US patent: US 8,435,520 B2.y

Publications

  • Publications ResearchGate
  • Publications Microsoft Academic Search
  • Publications in PubMed

Political activity

In 2014, the Neuried community elected Brenner as deputy CSU chairman to the local council and the building and environmental committee.

See also

literature

Web links

Individual evidence

  1. ↑ P. Brenner: The classical Big Bang Theory - The creation of matter in the Big Bang . In: Z. f. Cosmology . tape 16 , 2005, pp. 11-87 .
  2. ↑ P. Brenner: White holes, gray holes, light gray and dark gray holes as fundamental solution models for the current crisis in modern cosmology . In: Z. f. Cosmology . tape 16 , 2005, pp. 107-189 .
  3. ↑ P. Brenner: Branenwelten in string cosmology as a multi-verse . In: Z. f. Cosmology . tape 17 , 2007, p. 101-123 .
  4. ↑ VFR
  5. ↑ Munich lung tranplant group
  6. ↑ Herbert O. Vetter u. a .: Experience with the Novacor left ventricular assist system as a bridge to cardiac transplantation, including the new wearable system . In: The Journal of thoracic and cardiovascular surgery . tape 109 , no. 1 , 1995, p. 74-80 .
  7. ↑ JarvikHeart ( Memento of the original from December 20, 2014 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.jarvikheart.com
  8. ↑ a b Anja Liebermann: Comparison of the retroauricular, left ventricular support system (LVAD) Jarvik 2000 as a new alternative to heart transplantation with the system with abdominal power supply as a bridge to heart transplantation. Diss., 2011 ( PDF ) DNB 1038152283 .
  9. ↑ Transregio Research Group FOR 535 Multitransgenic donor animals and new immunosuppressive strategies in preclinical experimental xenotransplantation models
  10. ^ FOR 535 Xenotransplantation / Xenotransplantation
  11. ↑ Transregio-Collaborative Research Center SFB127 Biology of Xenogenic Cell and Organ Transplantation - from the Laboratory to the Clinic
  12. ^ Walter Brendel Center for Surgical Research
  13. ↑ Patent EP1980263A1 : Combinations of immunosuppressive agents for the treatment or prevention of transplant rejection. ‌
  14. ↑ a b Patent US2011142953A1 : Combinations of immunosuppressive agents for the treatment or prevention of graft rejections. ‌
  15. ↑ Patent US8435520 . ‌
  16. ↑ Preclinical and clinical xenotransplantation ( Memento of the original dated December 6, 2014 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.klinikum.uni-muenchen.de
  17. ↑ Comprehensive DFG funding for medicine at the TU Dresden
  18. ↑ Veronika Eder: Immune adsorption in heterotopic and orthotopic xenotransplantation of baboons, cynomolgus and rhesus monkeys with landrace and hDAF-transgenic pig hearts . (PDF) Dissertation
  19. ^ Cosmas Damian Wimmer: Diagnosis of rejection in heterotopic and orthotopic xenotransplantation of hDAF-transgenic pig hearts in the primate model with perioperative immunoadsorption . (PDF) Dissertation
  20. ↑ Katarina Barbara Feil: Lung transplants taking various preservation solutions into account. Influence of lung preservation on the results. A clinical study in 329 patients after orthotopic lung transplantation . (PDF) Dissertation
  21. ↑ Bruno Reichart and a .: Discordant cardiac xenotransplantation: broadening the horizons . In: European Journal of Cardio-Thoracic Surgery . tape 45 , no. 1 , January 1, 2014, p. 1-5 , doi : 10.1093 / ejcts / ezt483 , PMID 24096411 .
  22. ↑ Andreas Bauer u. a .: First experience with heterotopic thoracic pig-to-baboon cardiac xenotransplantation . In: Xenotransplantation . tape 17 , no. 3 , May 1, 2010, p. 243-249 , doi : 10.1111 / j.1399-3089.2010.00587.x .
  23. ↑ P. Brenner et al. a .: Combination of hDAF-transgenic pig hearts and immunoadsorption in heterotopic xenotransplantation of immunosuppressed baboons . In: Transplantation Proceedings . tape 37 , no. 1 , January 1, 2005, p. 483-486 , doi : 10.1016 / j.transproceed.2004.12.243 , PMID 15808683 .
  24. ↑ P. Brenner et al. a .: Mean xenograft survival of 14.6 days in a small group of hDAF-transgenic pig hearts transplanted orthotopically into baboons . In: Transplantation Proceedings . tape 37 , no. 1 , January 2005, p. 472-476 , doi : 10.1016 / j.transproceed.2004.12.241 .
  25. ↑ PDF ( Memento from December 5, 2014 in the Internet Archive )
  26. ↑ IG-therasorb immunoapheresis in orthotopic xenotransplantation of baboons with landrace pig hearts. ( Memento from December 5, 2014 in the Internet Archive )
  27. ↑ P. Brenner, M. Hinz, H. Huber, M. Schmoeckel, H. Reichenspumer, B. Meiser, C. Hammer, B. Reichart: Influence of ischemic time on hyperacute xenograft rejection of pig hearts in a working heart perfusion model with human blood . In: Transplant International . tape 13 , S1, June 1, 2000, pp. S494-S503 , doi : 10.1111 / j.1432-2277.2000.tb02091.x .
  28. ↑ P. Brenner et al. a .: Prevention of hyperacute xenograft rejection in orthotopic xenotransplantation of pig hearts into baboons using immunoadsorption of antibodies and complement factors . In: Transplant International . tape 13 , S1, June 1, 2000, pp. S508-S517 , doi : 10.1111 / j.1432-2277.2000.tb02093.x .
  29. ↑ Paolo Brenner, Michael Hinz, Harald Huber, Michael Schmoeckel, Hermann Reichenspurner, Bruno Meiser , Claus Hammer, Bruno Reichart: Effects of prolonged cold storage time in xenotransplantation . In: The Journal of Heart and Lung Transplantation . tape 18 , no. December 12 , 1999, pp. 1211-1217 , doi : 10.1016 / S1053-2498 (99) 00101-1 .
  30. ↑ Paolo Brenner, Michael Hinz, Harald Huber, Michael Schmoeckel, Hermann Reichenspurner, Bruno Meiser, Claus Hammer, Bruno Reichart: The influence of antibody and complement removal with a Ig-Therasorb column in a xenogeneic working heart model . In: European Journal of Cardio-Thoracic Surgery . tape 15 , no. 5 , January 5, 1999, p. 672-679 , doi : 10.1016 / S1010-7940 (99) 00080-9 .
  31. ↑ Andres Beiras-Fernandez u. a .: Extracorporeal membrane oxygenation in 108 patients with low cardiac output - a single-center experience . In: The International Journal of Artificial Organs . tape 34 , no. 4 , 2011, p. 365-373 , PMID 21534247 .
  32. ↑ ( Page no longer available , search in web archives: Drive technology from artificial hearts )@1@ 2Template: Toter Link / www.technik-in-bayern.de
  33. ↑ Herbert O. Vetter u. a .: Experience with the Novacor left ventricular assist system as a bridge to cardiac transplantation, including the new wearable system . In: The Journal of Thoracic and Cardiovascular Surgery . tape 109 , no. 1 , January 1995, p. 74-80 , doi : 10.1016 / S0022-5223 (95) 70422-1 .
  34. ↑ Patent EP1980263A1 . ‌
  35. ↑ MECUM training system ( Memento of the original from December 5, 2014 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.mecum-online.de
  36. ↑ Cardiac surgery LMU
  37. ↑ Student education system Modul23 ( Memento of the original from November 5, 2012 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.klinikum.uni-muenchen.de
  38. ↑ Further education events
  39. ↑ EACTS-Past-Award-Winners ( Memento of the original from December 13, 2014 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.eacts.org
  40. ↑ BiotestAwardRecipients9thCongressOslo  ( page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.@1@ 2Template: Dead Link / dev1274.esot.org  
  41. ↑ TTS
  42. ^ IXA
  43. ↑ Collaborative Research Center Transregio 127 ( Memento of the original dated December 6, 2014 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.klinikum.uni-muenchen.de
  44. ↑ google.com
  45. ↑ US 8,435,520 B2.y
  46. ↑ Publications ResearchGate
  47. ↑ Publications Microsoft Academic Search ( Memento of the original from November 26th, 2014 in the web archive archive.today ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / 65.54.113.26
  48. ^ Publications in PubMed
  49. ^ Members of the municipal council in Neuried
  50. ^ Neuried municipal council committees
personal data
SURNAME Brenner, Paolo
BRIEF DESCRIPTION German heart surgeon
DATE OF BIRTH May 21, 1966
PLACE OF BIRTH Höchstädt on the Danube