Saul Roseman

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Saul Roseman (born March 9, 1921 in Brooklyn , New York City , † July 2, 2011 ) was an American biochemist at Johns Hopkins University in Baltimore , Maryland .

Life

Roseman earned a bachelor's degree in chemistry from the City College of New York in New York City in 1941 and a master's degree from the University of Wisconsin as well as a Ph.D. in 1948 with Karl Paul Link after completing military service as an infantryman in Europe during World War II . with a thesis on coumarins and on dicarboxylic acid esters of glucose . As a postdoctoral fellow , he worked with Albert Dorfman at the University of Chicago on glycosaminoglycans . In 1953, Roseman was assistant professor at the University of Michigan at Ann Arbor , where he last held a full professorship. In 1959 he worked as a guest researcher ( sabbatical ) with the later Nobel Prize winner Har Gobind Khorana . From 1965 Roseman was Professor of Biochemistry at Johns Hopkins University in Baltimore , Maryland , where he was in charge of the entire Department of Biology from 1969 to 1973 and from 1988 to 1990. It was only shortly before his death that Roseman retired at the age of 90.

Roseman was married. His wife Martha Roseman , who, among other things, held the position of dean for academic advice at Johns Hopkins University , died just weeks after Saul Roseman. The couple had three children. Roseman's son-in-law, Ronald Schnaar is a professor at the Johns Hopkins University School of Medicine .

Act

Phosphotransferase system

Roseman and co-workers were able to elucidate the correct structure of N-acetylneuraminic acid (a sialic acid ) and characterize the first six known sialyltransferases . All in all, Roseman has done fundamental work on the biosynthesis of complex carbohydrates (sugars), their importance in cell interaction and the transport of sugars into the cell . Roseman developed an improved method for synthesizing the sugar fractions of nucleotides . In 1964 he discovered the phosphotransferase system as a mechanism for group translocation - a form of membrane transport in bacteria . The system also regulates the uptake of other substrates and chemotaxis towards them. The system also plays a role in the regulation of transcription (biology) of certain operons .

Awards (selection)

literature

Web links

Individual evidence

  1. ↑ Saul Roseman Ph.D. Wisconsin 1948 (PDF, 31 kB) at the University of Notre Dame (nd.edu); Retrieved June 3, 2012.
  2. ^ Martha Roseman, Hopkins associate dean, dies. The Baltimore Sun, July 29, 2011.
  3. ↑ Book of Members 1780 – Present (PDF, 159 kB) of the American Academy of Arts and Sciences (amacad.org); Retrieved June 3, 2012.
  4. ^ Past Winners - Rosenstiel Award - Rosenstiel Basic Medical Sciences Research Center - Brandeis University. In: brandeis.edu. Retrieved February 13, 2016 .
  5. ↑ Saul Roseman, Ph.D. at the Gairdner Foundation (gairdner.org); Retrieved August 7, 2012.
personal data
SURNAME Roseman, Saul
BRIEF DESCRIPTION American biochemist
DATE OF BIRTH March 9, 1921
PLACE OF BIRTH Brooklyn , New York City
DATE OF DEATH July 2, 2011