Sucralfate

from Wikipedia, the free encyclopedia
Structural formula
Structure of sucralfate
General
Non-proprietary name Sucralfate
Molecular formula C 12 H 54 Al 16 O 75 S 8
Brief description

White dust

External identifiers / databases
CAS number 54182-58-0
EC number 259-018-4
ECHA InfoCard 100.053.636
PubChem 121494085
DrugBank DB00364
Wikidata Q420394
Drug information
ATC code

A02 BX02

Drug class

Ulcer therapeutic

properties
Molar mass 2086.74 g · mol -1
Physical state

firmly

Melting point

130 ° C decomposes

solubility

soluble in dilute hydrochloric acid and sodium hydroxide solution , insoluble in water and ethanol

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data

> 12 g kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sucralfate is an aluminum - salt of sucrose sulfate .

effect

By taking sucralfate a protective film of sucralfate produced protein - complexes , of the gastric mucosa and a possible Ulcusgrund covered. Sucralfate also binds pepsin and bile acids . In addition, it has a protective effect on the mucous membrane through prostaglandin , bicarbonate and mucus formation.

Side effects

Aluminum causes clogging .

indication

Sucralfate is used in the therapy of a duodenal ulcer or gastric ulcer ("stress ulcer") and their prophylaxis . It can also be used to treat reflux esophagitis .

interaction

The focus is on a reduced absorption of certain substances due to an increase in the pH value in the stomach and / or binding of the substances in the gastrointestinal tract . For this reason, it is recommended that you leave at least 2 hours between taking sucralfate and other substances. Interactions exist e.g. B. with: beta blockers , antibiotics (such as cephalosporins , gyrase inhibitors and tetracyclines ), L - thyroxine , theophylline , vitamin B 12 and digitalis .

Trade names

Monopreparations

Sucrabest (D), Sucralan (A), Ulcogant (D, A, CH), various generics (D, A)

Individual evidence

  1. ↑ a b c Entry on sucralfate. In: Römpp Online . Georg Thieme Verlag, accessed on November 10, 2014.
  2. ↑ a b c data sheet Sucrose octasulfate – aluminum complex from Sigma-Aldrich , accessed on June 16, 2011 ( PDF ).