Sucralfate
Structural formula | |||||||||||||||||||
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General | |||||||||||||||||||
Non-proprietary name | Sucralfate | ||||||||||||||||||
Molecular formula | C 12 H 54 Al 16 O 75 S 8 | ||||||||||||||||||
Brief description |
White dust |
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External identifiers / databases | |||||||||||||||||||
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Drug information | |||||||||||||||||||
ATC code | |||||||||||||||||||
Drug class |
Ulcer therapeutic |
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properties | |||||||||||||||||||
Molar mass | 2086.74 g · mol -1 | ||||||||||||||||||
Physical state |
firmly |
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Melting point |
130 ° C decomposes |
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solubility |
soluble in dilute hydrochloric acid and sodium hydroxide solution , insoluble in water and ethanol |
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safety instructions | |||||||||||||||||||
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Toxicological data | |||||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Sucralfate is an aluminum - salt of sucrose sulfate .
effect
By taking sucralfate a protective film of sucralfate produced protein - complexes , of the gastric mucosa and a possible Ulcusgrund covered. Sucralfate also binds pepsin and bile acids . In addition, it has a protective effect on the mucous membrane through prostaglandin , bicarbonate and mucus formation.
Side effects
indication
Sucralfate is used in the therapy of a duodenal ulcer or gastric ulcer ("stress ulcer") and their prophylaxis . It can also be used to treat reflux esophagitis .
interaction
The focus is on a reduced absorption of certain substances due to an increase in the pH value in the stomach and / or binding of the substances in the gastrointestinal tract . For this reason, it is recommended that you leave at least 2 hours between taking sucralfate and other substances. Interactions exist e.g. B. with: beta blockers , antibiotics (such as cephalosporins , gyrase inhibitors and tetracyclines ), L - thyroxine , theophylline , vitamin B 12 and digitalis .
Trade names
Sucrabest (D), Sucralan (A), Ulcogant (D, A, CH), various generics (D, A)
Individual evidence
- ↑ a b c Entry on sucralfate. In: Römpp Online . Georg Thieme Verlag, accessed on November 10, 2014.
- ↑ a b c data sheet Sucrose octasulfate – aluminum complex from Sigma-Aldrich , accessed on June 16, 2011 ( PDF ).