Terbutryn

Structural formula
General
Surname	Terbutryn
other names	2- t -butylamino-4-ethylamino-6-methylthio- s- triazine 2- tert -Butylamino-4-ethylamino-6-methylthio-1,3,5-triazine
Molecular formula	C 10 H 19 N 5 S
Brief description	white to yellowish solid with a faint odor
External identifiers / databases
CAS number 886-50-0 EC number 212-950-5 ECHA InfoCard 100,011,773 PubChem 13450 ChemSpider 12874 DrugBank DB08215 Wikidata Q2404338
properties
Molar mass	241.36 g mol −1
Physical state	firmly
Melting point	104 ° C
boiling point	154–160 ° C (at 0.08 mbar )
solubility	very heavy in water (0.025 g l −1 at 20 ° C)
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 319-400 P: 273-305 + 351 + 338-337 + 313-391
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Terbutryn is a chemical compound with a 1,3,5-triazine ring as the basic structure. It is used as a herbicide .

use

Terbutryn comes as an algicide in z. B. emulsion paints are used. It is feared that it will be washed out slowly but steadily, and that it will enter the soil as well as surface and groundwater .

Admission

In the EU states including Germany and Austria as well as in Switzerland no pesticides with this active substance are permitted.

toxicology

Terbutryn is rapidly absorbed after oral administration. In the first 24 hours, 73–85% is excreted, mainly faecal . During the passage, terbutryn is completely metabolized , mainly by S- demethylation , hydrolysis of the SCH ₃ group, oxidative dealkylation of the amino group and oxidation of the alkyl groups to alcohols and acids that conjugate exclusively with glucuronic acids . Long-term effect through storage in adipose tissue and the brain - depending on the type of gene and additional toxins. Terbutryn is considered a neurotoxin . Symptoms range from diarrhea to breathing difficulties and CNS disorders .

Others

The EU Commission proposes adding terbutryn to the list of 33 pollutants that have to be monitored and controlled in EU surface waters. This revised list is also part of a directive amending the Water Framework Directive and the Directive on environmental quality standards.

Individual evidence

1. ↑ ^{a b c d e f} Entry on terbutryn in the GESTIS substance database of the IFA , accessed on February 1, 2016(JavaScript required) .
2. ↑ M. Brake: Are houses becoming more and more hazardous waste? In: Telepolis. February 1, 2011.
3. ↑ H. Venzmer: Biofilms and functional building material surfaces. 8th Dahlberg Colloquium on September 25, 2008 in Wismar. Fraunhofer IRB Verlag, Stuttgart 2008, ISBN 978-3-410-16894-2 .
4. ↑ Regulation (EC) No. 2076/2002 (PDF) of the Commission of November 20, 2002.
5. ↑ General Directorate Health and Food Safety of the European Commission: Entry on Terbutryn in the EU pesticide database; Entry in the national registers of plant protection products in Switzerland , Austria and Germany ; accessed on March 8, 2016.
6. ↑ M. Daunderer: Clinical Toxicology. Poison information, poison detection, poisoning therapy. ecomed, Landsberg / Lech 1995 to Dec. 2006, ISBN 3-609-70000-9 .
7. ↑ Environmental quality standards for surface waters