Ceftiofur
Structural formula | |||||||||||||
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General | |||||||||||||
Non-proprietary name | Ceftiofur | ||||||||||||
other names | |||||||||||||
Molecular formula | C 19 H 17 N 5 O 7 S 3 | ||||||||||||
Brief description |
white solid |
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Drug information | |||||||||||||
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properties | |||||||||||||
Molar mass | 523.55 g · mol -1 | ||||||||||||
Physical state |
firmly |
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Melting point |
186-198 ° C |
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pK s value |
3.7 |
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solubility |
bad in water (23 mg l −1 ) |
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Toxicological data | |||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Ceftiofur is a semisynthetic antibiotic from the third generation cephalosporin class , which was developed for veterinary medicine and first described in 1987.
indication
Ceftiofur is mainly used to treat bacterial infectious diseases in cattle and pigs .
Working principle
The antibiotic ceftiofur is effective against numerous gram-negative pathogens, e.g. B. Escherichia coli , Pasteurella , streptococci , staphylococci and salmonella by inhibiting the bacterial cell wall biosynthesis . Ceftiofur shows little or no efficacy against Enterococci , Pseudomonas and Camphylobacter strains.
Application
The active ingredient is administered as an injection subcutaneously at the base of the ear (in cattle) or intramuscularly at the neck muscle (in pigs).
Side effects
Local swelling at the injection site and digestive disorders (e.g. diarrhea ) may occur as side effects .
Trade names
Ceftiofur is commercially available as a sterile powder for dissolution in an aqueous solution, as the sodium salt or as the hydrochloride in an oily suspension .
The antibiotic is sold as a monopreparation under the following names:
Active ingredient | Trade names |
Ceftiofur |
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Ceftiofur Sodium |
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Ceftiofur hydrochloride |
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There is also a combination preparation with ketoprofen (trade name Curacef duo).
Individual evidence
- ↑ a b c d data sheet Ceftiofur at Sigma-Aldrich , accessed on January 9, 2019 ( PDF ).
- ↑ a b Entry on Ceftiofur in the Hazardous Substances Data Bank , accessed on December 1, 2019.
- ↑ ceftiofur: Summary Report (1) . European Medicines Agency , Committee for Veterinary Medicinal Products. 1999. Retrieved January 9, 2019.
- ↑ RJ Yancey, ML Kinney, BJ Roberts, KR Goodenough, JC Hamel: Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation in vitro and in vivo in mice . In: American Journal of Veterinary Research . tape 48 , no. 7 , 1987, pp. 1050-1053 , PMID 3631686 .
- ^ A b Rex E. Hornish, Susan F. Kotarski: Cephalosporins in veterinary medicine - ceftiofur use in food animals . In: Current Topics in Medicinal Chemistry . tape 2 , no. 7 , 2002, p. 717-731 , PMID 12052187 .
- ↑ a b c Entry on Ceftiofur. In: Römpp Online . Georg Thieme Verlag, accessed on January 9, 2019.
- ↑ Naxcel | European Medicines Agency. Retrieved January 9, 2019 .
- ↑ a b c Entry on Ceftiofur at Vetpharm, accessed on November 7, 2019.
- ↑ a b vetidata (as of January 11, 2019).