David C. Page

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David Conrad Page (born July 6, 1956 in Harrisburg , Pennsylvania ) is an American geneticist known for his work on the Y chromosome .

Life

Page earned a bachelor's degree in chemistry from Swarthmore College in Swarthmore , Pennsylvania in 1978 and an MD with David Botstein from Harvard Medical School in Boston , Massachusetts in 1984 (in partnership with the Massachusetts Institute of Technology , MIT) . As a postdoctoral fellow , he stayed with Botstein at MIT before becoming a member of the Whitehead Institute for Biomedical Research at MIT in 1988 . At the same time he received a professorship at MIT, first as an assistant professor , in 1992 as an associate professor and in 1997 as a full professor. Page has also been doing research for the Howard Hughes Medical Institute (HHMI) since 1990, and has been Director of the Whitehead Institute since 2005.

Act

Page and coworkers deal with basic research on the sex chromosomes of mammals, in particular with the structure, function and evolution of the Y chromosome . In 1986, Pages' group produced the first deletion map of the Y chromosome, in 1992 a physical gene map , in 1997 a systematic catalog of the genes on the chromosome and in 2003 (in collaboration with the Washington University Genome Sequencing Center ) the complete DNA sequencing within the framework of the Human genome project .

Page was able to prove that much more information is stored on the Y chromosome than just the coding for the male gender ( sex determining region of Y ). These include, on the one hand, several genes for the function of the testes and, on the other hand, several household genes that have homologues on the X chromosome . Page discovered the deletion of the AZFc on the Y chromosome as the cause of the most common form of azoospermia in humans.

He was able to reconstruct that the X and Y chromosomes arose from a pair of autosomes about 300 million years ago and that the Y chromosome only lost a single gene in the last 25 million years.

More recent work deals with the question of how the primordial germ cells differentiate into male or female gametes .

Page was an editor of the scientific journals Current Opinion in Genetics and Development and Annual Review of Genomics and Human Genetics .

Awards (selection)

Web links

Individual evidence

  1. ↑ David C. Page in the Notable Names Database (English)
  2. ↑ 1986 MacArthur Fellows at the John D. and Catherine T. MacArthur Foundation (macfound.org); Retrieved April 12, 2013
  3. ^ Recipients of the Amory Prize, 1940-2012 at the American Academy of Arts and Sciences (amacad.org); Retrieved April 12, 2013
  4. ^ Past Recipients: Curt Stern Award at the American Society of Human Genetics (ashg.org); Retrieved April 12, 2013
  5. ↑ David C. Page at the National Academy of Sciences (nasonline.org); Retrieved April 12, 2013
  6. ↑ March of Dimes Awards $ 250,000 Prize to Scientists Who Explained Human Sex Chromosomes - March of Dimes. In: marchofdimes.org. Retrieved February 20, 2016 .
  7. ↑ Book of Members 1780 – present (PDF, 917 kB) at the American Academy of Arts and Sciences (amacad.org); Retrieved April 12, 2013
personal data
SURNAME Page, David C.
ALTERNATIVE NAMES Page, David; Page, David Conrad
BRIEF DESCRIPTION American geneticist
DATE OF BIRTH July 6, 1956
PLACE OF BIRTH Harrisburg, Pennsylvania