Nicotinyl alcohol

Structural formula
General
Non-proprietary name	Nicotinyl alcohol
other names	3-pyridylmethanol; Pyridin-3-ylmethanol ( IUPAC );
Molecular formula	C 6 H 7 NO
Brief description	yellow liquid with a pyridine- like odor
External identifiers / databases
EC number	202-864-6
ECHA InfoCard	100.002.604
PubChem	7510
ChemSpider	7229
DrugBank	DB04145
Wikidata	Q411732
Drug information
ATC code	C04 AC02 ; C10 AD05 ;
Drug class	peripheral vasodilator ; Lipid reducers;
properties
Molar mass	109.13 g · mol -1
Physical state	liquid
density	1.13 g cm −3 (20 ° C)
Melting point	−7 ° C
boiling point	259 ° C
Vapor pressure	0.342 Pa (20 ° C)
solubility	completely miscible with water
Refractive index	1.545 (20 ° C)
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 319
	P: 264-280-305 + 351 + 338
Toxicological data	1000 mg kg −1 ( LD 50 , mouse , iv )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Nicotinyl alcohol (also known as pyridyl methanol ) is a drug that is no longer on the market and was used to treat disorders of lipid metabolism .

Clinical information

The drug is indicated for hyperlipoproteinaemia of type II-V according to Fredrickson . It also has a peripheral vasodilator effect ( vasodilation ).

Pharmacological properties

Nicotinyl alcohol lowers total cholesterol , VLDL , LDL cholesterol, and triglycerides in blood serum by reducing the synthesis of VLDL. It is oxidized to nicotinic acid in the liver .

literature

JC Frölich, W. Kirch (Hrsg.): Practical medicine therapy . Springer-Verlag, 2003, ISBN 3-540-01025-4 , pp. 543-545 ( excerpt from Google book search).

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h Entry on 3-pyridylmethanol in the GESTIS substance database of the IFA , accessed on December 22, 2019(JavaScript required) .

↑ 3-Pyridinemethanol data sheet from Sigma-Aldrich , accessed on April 16, 2011 ( PDF ).

^ Entry on nicotinyl alcohol in the ChemIDplus database of the United States National Library of Medicine (NLM) .

[GESTIS-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h Entry on 3-pyridylmethanol in the GESTIS substance database of the IFA , accessed on December 22, 2019(JavaScript required) .