Uwe-Frithjof Haustein

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Portrait of Uwe-Frithjof Haustein on the occasion of a ceremony

Uwe-Frithjof Haustein (born February 20, 1937 in Dresden ) is a German medic. From 1975 to 2002 he was director of the Clinic and Polyclinic for Dermatology, Venereology and Allergology at the University of Leipzig and from 1976 a full professor there. Since 1988 he has been a full member of the Saxon Academy of Sciences in Leipzig , from 2005 to 2007 he was its president and since 2005 he has been the chairman of the academy's friends' association.

Career

Uwe Frithjof Haustein is the third of four children of the couple Friedrich Paul Max Haustein (independent master furrier) and Agnes Irmgard born. Schwalm (typist / secretary). After graduating from high school at the Cross School of Dresden studied Haustein medicine at the former Karl Marx University in Leipzig (1954-1956) and then at the Medical Academy Carl Gustav Carus Dresden (1956-1959), put in 1959 his state exam , and got a doctorate. After compulsory assistantship (1960) and a general practical year (1961), specialist training took place under Heinz-Egon Kleine-Natrop in Dresden (1962–1964). In 1967 he moved to Niels Sönnichsen as a senior physician at the Jena University Hospital , where he received his habilitation in 1969 on the subject of "Physiology and pathology of local fibrinolysis in healthy and diseased skin".

From 1970 to 1975, Haustein was Deputy Clinic Director of the Charité University Dermatology Clinic , also under Niels Sönnichsen. In 1974 he was appointed lecturer. In 1975 he was appointed clinic director, in 1976 he was appointed full professor of the clinic and polyclinic for dermatology, venereology and allergology at the University of Leipzig, and in 2002 he retired. The clinic and polyclinic includes all clinical areas such as classical dermatology, venereology, allergology, occupational dermatology, pediatric dermatology, phlebology, dermatosurgery, andrology, photodermatology, dermatohistopathology and mycology. The clinic operated up to 6 wards with a maximum of 149 beds in 1975, 49 beds in 2002. In 1986 the department for experimental dermatology was founded at the clinic.

From 1984 to 1990 he was the chairman of the dermatological society of the then GDR . At the same time, he was deputy dean for research in the university's medical faculty. Haustein was an honorary member of eight foreign dermatological societies, and he was also active in the International Union against venereal Diseases and Treponematoses (IUVDT) for over 10 years. As early as 1975, an interdisciplinary consultation hour for skin cancer patients (tumor board) was launched at the University of Leipzig in order to achieve optimal care in cooperation with radiologists, surgeons, internists and other specialist clinics.

In 1988 he was elected a full member of the Saxon Academy of Sciences in Leipzig . From 1999, Haustein held management positions as deputy and later full secretary of the mathematics and natural sciences class in the Academy's executive committee, from 2005 to 2007 he was its president. In 2005, Haustein founded the Friends of the Saxon Academy of Sciences and has been its elected chairman ever since. So far, 14 prizes have been awarded to young scientists as part of research funding, as well as numerous printing and travel allowances. Since his election as a full member of the German Academy of Science and Engineering (acatech) in 2008, he has been working in its thematic network “Health Technology ”.

Since 1991, Haustein has been working as an expert in the assessment of clinical cases at the Documentation Center for Severe Skin Reactions ( Stevens-Johnson Syndrome , Toxic Epidermal Necrolysis TEN) at the Freiburg University Skin Clinic. For decades he worked as an international reviewer on issues related to work-related scleroderma .

Honors

Research areas

Haustein wrote nine monographs, including on dermatological local therapy and sexually transmitted diseases. He also wrote over 60 book chapters, over 750 scientific publications and gave over 1050 scientific lectures. In the course of his research work, Haustein supervised 18 post-doctoral qualifications as well as over 100 doctorates from doctors and scientists.

From 1990 to 2005, Haustein headed the long-term project "Human Ecological Medical Research" of the Saxon Academy of Sciences in Leipzig on questions of environment-induced systemic scleroderma, primarily through quartz dust, wound healing and tumor-matrix interactions, not least through cells -Co-cultures.

Local fibrinolysis

In addition to clinical issues, Haustein was also interested in experimental issues from the start, initially in local fibrinolysis of the skin (Habilitation 1969 in Jena). The plasminogen activator released from endothelial cells was characterized by means of the histochemical fibrin plate method (autography), biochemical investigations and animal experiments (skin transplants on mice) and influenced by means of fibrinolysis inhibitors such as para-aminomethylbenzoic acid (PAMBA).

Autoimmune diseases

At the same time, histological and electron microscopic examinations, cell physiological and immunological work followed, and later molecular biological and genetic contributions. Overall, he succeeded in developing the clinic into a center for immunodermatology, in particular with investigations into the clinical pictures of systemic and local lupus erythematosus , dermatomyositis , systemic scleroderma and bullous pemphigoid .

In the case of lupus erythematosus, the immune complex-mediated changes triggered by mouse leukemia viruses in various organ systems were first described in F1 hybrid mice as a disease model. Later, electron microscopy , particularly in, endothelium of various organs of man, tubulo-reticular structures found their viral nature could not be proved ultimately.

The immune complex cleavage by means of molar urea resulted in an increase in the titre of the autoantibodies in systemic lupus erythematosus as well as in bullous pemphigoid, which allows a better correlation between antibody titers and clinically active disease progression. The interleukin-2 receptor expression and their release to play in the pathogenesis of bullous pemphigoid a role. The reactivity of antibodies from patients on plotted epidermal extracts was compared with immunofluorescence . HLA B7 was identified as a marker for the poor response to immunosuppressive therapy. Together with complement and proteinases from neutrophils, the bullous pemphigoid antibodies mediate dermo-epidermal separation.

Progressive scleroderma

In progressive scleroderma, the acid lysosomal hydrolases were changed and there were also deviations in the content of collagen I and III, fibronectin and collagenase in the skin tissue. The collagen aminopropeptide and laminin P1 levels were found to be elevated in the serum as a sign of activation. The serum levels of chemokines, interleukins and growth factors were increased in scleroderma. The possibility of microchimerism is discussed pathogenetically. The prostacyclin analogue iloprost increases adhesion molecules and growth factors, which explain the therapeutic effect via the vascular system.

Environment-induced scleroderma

It could be shown that the environment-induced scleroderma can also be caused by chemicals, X-rays and also by quartz dust (often due to occupational reasons as a result of inadequate health and safety precautions). In the quartz dust-induced form in particular, no differences to idiopathic scleroderma with regard to clinical, serological and immunological markers were found. Here too, there was an increased expression of interstitial collagenase. Quartz is able to induce the adhesion molecule ICAM1 in endothelial cells.

Fibroblast-specific antibody

Anja Saalbach's work group at the Leipzig University Hospital found the monoclonal antibody AS02, which was found to be homologous to the Thy1 protein and showed specificity for fibroblasts . It is important for the discovery and elimination of fibroblasts. Thy1 was detected in serum from fibroblasts and endothelial cells, it also comes from polymorphonuclear leukocytes and binds to fibroblasts and endothelial cells. It exhibits adherence to neutrophils.

Tumor-matrix interaction

Fibroblasts around malignant melanoma produce increased matrix metallo- proteinase MMP as well as increased expression of adhesion molecules ICAM-1, d. H. they promote the spread and adhesion of tumor cells and thus metastasis . Thy1 ( CD90 ) and integrin avß3 ( CD51 / CD61 ) support melanoma cell adhesion to activated endothelial cells. The Mel 4B3 mRNA, which is induced in skin tumors, is regulated by growth factors (TGFß) and proinflammatory cytokines .

Permethrin in the therapy of scabies

In 1986, local therapy for scabies using permethrin (including endemics in old people's and nursing homes) and local therapy for rosacea with metronidazole were introduced. Permethrin was compared with allethrin and benzoyl peroxide , the pyrethrins and pyrethroids discussed and an algorithm for the eradication of chronic scabies crustosa and pandemics in old people's and nursing homes with permethrin and ivermectin was presented.

Personal

Hausein has been married since 1968. The couple has a daughter. Hausein has played the recorder, violin and piano since his childhood, and church organ since his youth, occasionally also in public. He often hiked in the mountains (in rope teams up to 4200 m altitude) and enjoys cycling.

Publications (selection)

Monographs

  • Haustein, U.-F., Barth, J., Fickweiler, E .: Dermatological local therapy. VEB Verlag Volk und Gesundheit 1986, 2nd edition 1991; doi: 10.1007 / 978-3-642-78163-6_61
  • Haustein, U.-F .: Sexually transmitted diseases. 1st edition. Fischer Verlag Jena, 1990, ISBN 3-334-00275-6 .
  • Haustein, U.-F., Herrmann, K., Ziegler, V .: The progressive scleroderma - model of an immunologically dysregulated fibrosis. In: Meeting reports of the Saxon Academy of Sciences in Leipzig. Mathematical and natural science class, Volume 122, Issue 5, Akademie Verlag 1991, ISBN 3-05-501334-4 .
  • Haustein, U.-F .: Environment-induced scleroderma. In: Meeting reports of the Saxon Academy of Sciences in Leipzig. Mathematical and natural science class, Volume 125, Issue 2, Akademie-Verlag 1994, ISBN 3-05-501669-6 .
  • Haustein, U.-F .: The chronic urticaria: A complex disorder in the dialogue with the environment. In: Session report of the Saxon Academy of Sciences in Leipzig, Mathematical and Natural Science Class, Volume 127, Issue 1, 1998, 37 pages, ISBN 3-7776-0878-5 .
  • S. Harland, U.-F. Haustein: "Herpes and shingles - The secret widespread disease", In: Herpes and shingles, publisher: Urania Verlag Berlin 1999, 63 pages, ISBN 3-332-01016-6 .
  • Haustein, U.-F .: Non-melanoma (“Heller”) skin cancer and its precursors. Meeting reports of the Saxon Academy of Sciences in Leipzig. Mathematical and natural science class Volume 131, Issue 2. pp. 1–40. SAW publishing house at S. Hirzel, Stuttgart / Leipzig 2009, ISBN 978-3-7776-1670-4 .
  • Haustein, U.-F .: Aging in the modern age. Meeting reports of the Saxon Academy of Sciences in Leipzig. Mathematical and natural science class Volume 131, Issue 2. pp. 1–40. SAW publishing house at S. Hirzel, Stuttgart / Leipzig 2010, ISBN 978-3-7776-1670-4 .
  • Mössner, J. Haustein, U.-F. (Ed.): Selected aspects of individualized medicine. Festive Symposium of the Saxon Academy of Sciences in Leipzig on the occasion of the 80th birthday of former President OM Prof. Dr. Uwe-Frithjof Haustein on March 31, 2017 in Leipzig. Treatises of the Mathematical and Natural Science Class Volume 66, Book 3; S. Hirzel Stuttgart / Leipzig 2018, ISBN 978-3-7776-2729-8 .

Book chapters (selection)

  • HAUTEIN, U.-F .: Mechanisms of bacterial skin infections. In: The skin as a defense organ. Editors: Braun-Falco, O., Geiler, G., Jablonska, St. - Wissenschaftliche Verlagsgesellschaft mbH Stuttgart 1991, ISBN 978-3-8047-1150-1 .
  • Haustein, U.-F .: Autoimmune diseases caused by disorders of immune regulation and programmed cell death (apoptosis). In: Contributions from members of the Saxon Academy of Sciences in Leipzig on the 150th anniversary of its foundation under the topic "Paths and Advances in Science". Editors: G. Haase and E. Eichler - Akademie-Verlag Berlin, ISBN 978-3-0500-3134-7 , pp. 699-707.
  • Saalbach, A., Wandel, E., Anderegg, U., Haustein, U.-F .: The malignant melanoma: clinical picture and biological behavior in its surrounding matrix. In: Environment and people - long-term effects and conclusions for the future. Treatises of the Saxon Academy of Sciences in Leipzig - Mathematical and natural science class. Editors: W. Fritsche, L. Zerling - Verlag der Sächsische Akademie der Wissenschaften zu Leipzig 2002, Vol. 59, H. 5, ISBN 978-3-7776-1155-6 , pp. 115–127.
  • Anderegg, U., Haustein, U.-F .: Environment-induced scleroderma due to long-term exposure to quartz - clinical observations and laboratory experiments. In: Environment and people - long-term effects and conclusions for the future. Treatises of the Saxon Academy of Sciences in Leipzig - Mathematical and natural science class. Editors: W. Fritsche, L. Zerling - Verlag der Sächsische Akademie der Wissenschaften zu Leipzig 2002, Vol. 59, H. 5, ISBN 978-3-7776-1155-6 , pp. 129-137.
  • Haustein, U.-F .: Medical aspects of neuroenhancements. In: The human of the future - background, goals and problems of human enhancement. Conference of the Science and Values ​​Commission in Leipzig, 17./18; February 2012. Papers of the Saxon Academy of Sciences. Philological-historical class. Volume 82, Issue 3. Ed. U. Ebert, O. Riha and L. Zerling, commissioned by S. Hirzel Stuttgart / Leipzig 2013, ISBN 978-3-7776-2384-9 , pp. 159-169.
  • Haustein, U.-F., Lietzberg, B .: Occupational Connective Tissue Disorders. In: Kanerva's Occupational Dermatology. 3rd Ed. Eds. Rustemeyer, T .; P. Elsner; SM John; HI Maibach; Springer Verlag 2018, pp. 301–326 doi: 10.1007 / 978-3-319-40221-5_29-2

Individual evidence

  1. ↑ Haustein, U.-F .: Normal values ​​of electrophoresis using the interferometric method according to ANTWEILER. Inaug. Dissertation Dresden 1959.
  2. ^ Catalog of the German National Library. Retrieved August 10, 2020 .
  3. ^ Professor catalog of the University of Leipzig - The professors database for Leipzig. Retrieved August 10, 2020 .
  4. ↑ Pietro Nenoff, Jörg Kleine-Tebbe and Jan C. Simon: Prof. Dr. med. habil. Uwe-Frithjof Haustein on his 80th birthday. In: Ärzteblatt Sachsen. March 1, 2017, accessed on August 10, 2020 (German).
  5. ^ Professor catalog of the University of Leipzig - The professors database for Leipzig. Retrieved August 10, 2020 .
  6. ↑ Uwe-Frithjof Haustein, Prof. Dr. med. habil. - Saxon Academy of Sciences. Retrieved August 10, 2020 .
  7. ↑ Young Talent Award - Saxon Academy of Sciences. Retrieved August 10, 2020 .
  8. ^ Uwe-Frithjof Haustein Saxon Academy of Sciences in Leipzig. In: acatech. Retrieved on August 10, 2020 (German).
  9. ↑ Saxon Order of Merit awarded to former President Uwe-Frithjof Haustein - Saxon Academy of Sciences. Retrieved August 10, 2020 .
  10. ↑ Former President Prof. Uwe-Frithjof Haustein receives Federal Order of Merit, First Class - Saxon Academy of Sciences. Retrieved August 10, 2020 .
  11. ^ Human-ecological-medical research - Saxon Academy of Sciences. Retrieved August 10, 2020 .
  12. ↑ Haustein, U.-F .: Quantitative determination of the tissue activator of fibrinolysis in healthy and diseased skin. In: Arch. Klin. exper. Dermatol. No. 232 , 1969, p. 245-259 .
  13. ^ Catalog of the German National Library. Retrieved August 14, 2020 .
  14. ↑ Uwe-Frithjof Haustein: Tubular structures in affected and normal skin in chronic discoid and systemic lupus erythematosus: electron microscopic studies . In: British Journal of Dermatology . tape 89 , no. 1 , 1973, ISSN  1365-2133 , pp. 1–14 , doi : 10.1111 / j.1365-2133.1973.tb01909.x .
  15. ↑ Herrmann, K., Lohrisch, I., Böhme, H.-J., Haustein, U.-F .: Detection of antibodies after immune complex splitting in serum of patients with bullous pemphigoid and systemic lupus erythematosus. In: Brit. J. Dermatol. No. 99 , 1978, pp. 635-640 .
  16. ↑ Schaller, J., Giese, T., Ladusch, M., Haustein, U.-F .: Interleukin-2-receptor expression and interleukin-2-production in bullous pemphigoid . In: Arch. Dermatol. Res. No. 282 , 1990, pp. 829 .
  17. ↑ Haustein, U.-F .: Reactivity of sera from bullous pemphigoid patients on blotted epidermal extracts as compared to indirect immunofluorescence technique . In: J. Invest. Dermatol. No. 94 , 1990, pp. 223-226 .
  18. ↑ J. Schaller, W. Feleke, UF Haustein, C. Baldauf, G. Kunze: HLA in bullous pemphigoid. The probable role of HLA-B7 as a marker for poor responders to immunosuppressive therapy . In: International Journal of Dermatology . tape 30 , no. 1 , January 1991, ISSN  0011-9059 , pp. 36-38 , doi : 10.1111 / j.1365-4362.1991.tb05876.x , PMID 1993562 .
  19. ^ UF Haustein, I. Lohrisch, K. Herrmann: Pathogenetic studies in bullous pemphigoid - review of the literature and our own results . In: The Journal of Dermatology . tape 11 , no. 6 , December 1984, ISSN  0385-2407 , pp. 508-518 , doi : 10.1111 / j.1346-8138.1984.tb01517.x , PMID 6399050 .
  20. ^ UF Haustein: The role of bullous pemphigoid antibodies in dermal-epidermal separation . In: The Journal of Investigative Dermatology . tape 92 , no. 1 , January 1989, ISSN  0022-202X , pp. 133 , doi : 10.1111 / 1523-1747.ep13071360 , PMID 2642509 .
  21. ↑ K. Herrmann, U.-F. Haustein, H.-J. Böhme, I. Lohrisch: Acid lysosomal hydrolases in systemic sclerosis and other connective tissue diseases . In: British Journal of Dermatology . tape 106 , no. 5 , 1982, ISSN  1365-2133 , pp. 523-528 , doi : 10.1111 / j.1365-2133.1982.tb04554.x .
  22. ↑ K. Herrmann, M. Heckmann, M. Kulozik, UF Haustein, T. Krieg: Steady-state mRNA levels of collagens I, III, fibronectin, and collagenase in skin biopsies of systemic sclerosis patients . In: The Journal of Investigative Dermatology . tape 97 , no. 2 , August 1991, ISSN  0022-202X , pp. 219-222 , doi : 10.1111 / 1523-1747.ep12480157 , PMID 1649227 .
  23. ↑ K. Herrmann, E. Schulze, M. Heckmann, I. Schubert, M. Meurer: Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma . In: The British Journal of Dermatology . tape 123 , no. 1 , July 1990, ISSN  0007-0963 , pp. 1-7 , doi : 10.1111 / j.1365-2133.1990.tb01818.x , PMID 2117968 .
  24. ↑ Bruns, M., Haustein, U.-F., Hofmann, C., Herrmann, K .: Serum levels of soluble IL-2-receptor, soluble ICAM-1, TNF-alpha, interleukin-4 and interleukin-6 in scleroderma. In: J. Eur. Acad. Dermatol. Venereol. No. 8 , 1997, pp. 222-228 .
  25. ↑ U. Anderegg, A. Saalbach, UF Haustein: Chemokine release from activated human dermal microvascular endothelial cells - implications for the pathophysiology of scleroderma? In: Archives of Dermatological Research . tape 292 , no. 7 , July 2000, ISSN  0340-3696 , p. 341-347 , doi : 10.1007 / s004030000134 , PMID 10966058 .
  26. ^ UF Haustein, U. Anderegg: Pathophysiology of scleroderma: an update . In: Journal of the European Academy of Dermatology and Venereology: JEADV . tape 11 , no. 1 , July 1998, ISSN  0926-9959 , p. 1-8 , PMID 9731958 .
  27. ↑ U.-F. Hausein: MicrochimerismNew approach to the pathogenesis of systemic scleroderma . In: The dermatologist . tape 51 , no. 2 , February 1, 2000, ISSN  0017-8470 , p. 59-62 , doi : 10.1007 / s001050050012 .
  28. ↑ Uwe-Frithjof Haustein: Systemic Sclerosis - An Update . In: Laboratory Medicine . tape 42 , no. 9 , September 1, 2011, ISSN  0007-5027 , p. 562-572 , doi : 10.1309 / LM9OB5BZ4OSNVGVF ( oup.com [accessed August 10, 2020]).
  29. ↑ Philipp Rehberger, Petra Beckheinrich-Mrowka, Uwe-Frithjof Haustein, Michael Sticherling: Prostacyclin analogue iloprost influences endothelial cell-associated soluble adhesion molecules and growth factors in patients with systemic sclerosis: a time course study of serum concentrations . In: Acta Dermato-Venereologica . tape 89 , no. 3 , 2009, ISSN  0001-5555 , p. 245-249 , doi : 10.2340 / 00015555-0632 , PMID 19479119 .
  30. ^ UF Haustein, V. Ziegler: Environmentally induced systemic sclerosis-like disorders . In: International Journal of Dermatology . tape 24 , no. 3 , April 1985, ISSN  0011-9059 , pp. 147-151 , doi : 10.1111 / j.1365-4362.1985.tb05745.x , PMID 2581908 .
  31. ^ UF Haustein, V. Ziegler, K. Herrmann: [Chemically-induced scleroderma] . In: The dermatologist; Journal of Dermatology, Venereology, and Related Fields . tape 43 , no. 8 , August 1992, ISSN  0017-8470 , p. 469-474 , PMID 1506211 .
  32. ^ UF Haustein: [Exacerbation of progressive scleroderma following roentgen therapy] . In: The dermatologist; Journal of Dermatology, Venereology, and Related Fields . tape 41 , no. 8 , August 1990, ISSN  0017-8470 , p. 448-450 , PMID 2177048 .
  33. ↑ J. Varga, UF Haustein, RH Creech, JP Dwyer, SA Jimenez: Exaggerated radiation-induced fibrosis in patients with systemic sclerosis . In: JAMA . tape 265 , no. 24 , June 26, 1991, ISSN  0098-7484 , pp. 3292-3295 , PMID 2046111 .
  34. ↑ Deutscher Ärzteverlag GmbH, editorial office of Deutsches Ärzteblatt: Experimental studies on quartz-induced scleroderma. May 1, 1998, accessed August 10, 2020 .
  35. ^ UF Haustein, U. Anderegg: Silica induced scleroderma - clinical and experimental aspects . In: The Journal of Rheumatology . tape 25 , no. October 10 , 1998, ISSN  0315-162X , p. 1917-1926 , PMID 9779844 .
  36. ^ MH Rustin, HA Bull, V. Ziegler, J. Mehlhorn, UF Haustein: Silica-associated systemic sclerosis is clinically, serologically and immunologically indistinguishable from idiopathic systemic sclerosis . In: The British Journal of Dermatology . tape 123 , no. December 6 , 1990, ISSN  0007-0963 , pp. 725-734 , doi : 10.1111 / j.1365-2133.1990.tb04189.x , PMID 2176091 .
  37. ↑ Anderegg, U., Vorberg, S., Herrmann, K., Haustein, U.-F .: Increased expression of interstitial collagenase in silica-treated fibroblasts . In: Eur. J. Dermatol. No. 6 , 1996, pp. 51-55 .
  38. ↑ Anderegg, U., Vorberg, S., Herrmann, K., Haustein, U.-F .: Silica directly induces ICAM-1 expression in cultured endothelial cells . In: Eur. J. Dermatol. No. 7 , 1997, pp. 27-31 .
  39. ↑ A. Saalbach, U. Aneregg, M. Bruns, E. Schnabel, K. Herrmann: Novel fibroblast-specific monoclonal antibodies: properties and specificities . In: The Journal of Investigative Dermatology . tape 106 , no. 6 , June 1996, ISSN  0022-202X , pp. 1314-1319 , doi : 10.1111 / 1523-1747.ep12349035 , PMID 8752676 .
  40. ↑ A. Saalbach, R. Kraft, K. Herrmann, UF Haustein, U. Anderegg: The monoclonal antibody AS02 recognizes a protein on human fibroblasts being highly homologous to Thy-1 . In: Archives of Dermatological Research . tape 290 , no. 7 , July 1998, ISSN  0340-3696 , p. 360-366 , doi : 10.1007 / s004030050318 , PMID 9749990 .
  41. ↑ Anderegg, U., Vorberg, S., Herrmann, K., Haustein, U.-F .: Increased expression of interstitial collagenase in silica-treated fibroblasts . In: Eur. J. Dermatol. No. 6 , 1996, pp. 51-55 .
  42. ^ A. Saalbach, G. Aust, UF Haustein, K. Herrmann, U. Anderegg: The fibroblast-specific MAb AS02: a novel tool for detection and elimination of human fibroblasts . In: Cell and Tissue Research . tape 290 , no. 3 , December 1997, ISSN  0302-766X , p. 593-599 , doi : 10.1007 / s004410050964 , PMID 9369534 .
  43. ^ A. Saalbach, T. Wetzig, UF Haustein, U. Anderegg: Detection of human soluble Thy-1 in serum by ELISA. Fibroblasts and activated endothelial cells are a possible source of soluble Thy-1 in serum . In: Cell and Tissue Research . tape 298 , no. 2 , November 1999, ISSN  0302-766X , p. 307-315 , doi : 10.1007 / s004419900079 , PMID 10571119 .
  44. ↑ A. Saalbach, UF Haustein, U. Anderegg: A ligand of human thy-1 is localized on polymorphonuclear leukocytes and monocytes and mediates the binding to activated thy-1-positive microvascular endothelial cells and fibroblasts . In: The Journal of Investigative Dermatology . tape 115 , no. 5 , November 2000, ISSN  0022-202X , p. 882-888 , doi : 10.1046 / j.1523-1747.2000.00104.x , PMID 11069627 .
  45. ↑ Anne Wetzel, Tino Wetzig, Uwe F. Haustein, Michael Sticherling, Ulf Anderegg: Increased neutrophil adherence in psoriasis: role of the human endothelial cell receptor Thy-1 (CD90) . In: The Journal of Investigative Dermatology . tape 126 , no. 2 , February 2006, ISSN  0022-202X , p. 441-452 , doi : 10.1038 / sj.jid.5700072 , PMID 16374458 .
  46. ↑ Ulf Anderegg, Kerstin Breitschwerdt, Martin J. Köhler, Michael Sticherling, Uwe-Frithjof Haustein: MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF-beta and pro-inflammatory cytokines . In: Experimental Dermatology . tape 14 , no. 9 , September 2005, ISSN  0906-6705 , p. 709-718 , doi : 10.1111 / j.0906-6705.2005.00349.x , PMID 16098131 .
  47. ↑ E. Wandel, A. Grasshoff, M. Mittag, UF Haustein, A. Saalbach: Fibroblasts surrounding melanoma express elevated levels of matrix metalloproteinase-1 (MMP-1) and intercellular adhesion molecule-1 (ICAM-1) in vitro . In: Experimental Dermatology . tape 9 , no. 1 , February 2000, ISSN  0906-6705 , p. 34-41 , doi : 10.1034 / j.1600-0625.2000.009001034.x , PMID 10688373 .
  48. ↑ Anja Saalbach, Anne Wetzel, Uwe-Frithjof Haustein, Michael Sticherling, Jan C. Simon: Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51 / CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium . In: Oncogene . tape 24 , no. 29 , July 7, 2005, ISSN  0950-9232 , p. 4710-4720 , doi : 10.1038 / sj.onc.1208559 , PMID 15897908 .
  49. ↑ Ulf Anderegg, Kerstin Breitschwerdt, Martin J. Köhler, Michael Sticherling, Uwe-Frithjof Haustein: MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF-beta and pro-inflammatory cytokines . In: Experimental Dermatology . tape 14 , no. 9 , September 2005, ISSN  0906-6705 , p. 709-718 , doi : 10.1111 / j.0906-6705.2005.00349.x , PMID 16098131 .
  50. ^ UF Haustein, B. Hlawa: Treatment of scabies with permethrin versus lindane and benzyl benzoate . In: Acta Dermato-Venereologica . tape 69 , no. 4 , 1989, ISSN  0001-5555 , pp. 348-351 , PMID 2472724 .
  51. ^ UF Haustein: [Pyrethrin and pyrethroid (permethrin) in the treatment of scabies and pediculosis] . In: The dermatologist; Journal of Dermatology, Venereology, and Related Fields . tape 42 , no. 1 , January 1991, ISSN  0017-8470 , pp. 9-15 , PMID 2010292 .
  52. ↑ U. Paasch, UF Haustein: [Treatment of endemic scabies with allethrin, permethrin and ivermectin. Evaluation of a treatment strategy] . In: The dermatologist; Journal of Dermatology, Venereology, and Related Fields . tape 52 , no. 1 , January 2001, ISSN  0017-8470 , p. 31-37 , doi : 10.1007 / s001050051258 , PMID 11220236 .
  53. ↑ U. Paasch, UF Haustein: Management of endemic outbreaks of scabies with allethrin, permethrin, and ivermectin . In: International Journal of Dermatology . tape 39 , no. 6 , June 2000, ISSN  0011-9059 , p. 463-470 , doi : 10.1046 / j.1365-4362.2000.00990.x , PMID 10944095 .
  54. ^ Professor catalog of the University of Leipzig - The professors database for Leipzig. Retrieved August 10, 2020 .
personal data
SURNAME Haustein, Uwe-Frithjof
BRIEF DESCRIPTION German doctor, dermatologist, venereologist, allergist and university professor
DATE OF BIRTH February 20, 1937
PLACE OF BIRTH Dresden