Angela Hartley Brodie

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Angela Hartley Brodie (born September 28, 1934 in Oldham , England - † June 7, 2017 in Fulton , Howard County , Maryland ) was an American cancer researcher and professor of pharmacology and experimental therapy at the medical school of the University of Maryland . She worked there at the Greenebaum Marlene and Stewart Greenebaum Cancer Center on the research program Hormone Responsive Cancers . Angela Brodie became known for her pioneering work in the development of aromatase inhibitors , which are now used in the treatment of breast cancer worldwide.

Life

Angela Hartley grew up with her eight years younger brother in a family of mountaineers and developed herself into a gifted climber. Her father Herbert Hartley, a chemist specializing in polyurethanes , inspired her to do scientific work. She herself said about him: "He was always talking to me about science, ... always interesting me in it." (German: "He was always talking to me about science, ... was always interested in it .") After visiting one of them for nine years She graduated from the University of Sheffield with a degree in biochemistry from Quaker- run boarding schools , which she graduated with a bachelor's degree. This was followed by a job at a blood bank , where she did routine assays to determine the Rhesus factor in the hope of being able to take on further tasks in medical research. It was ultimately by chance that she got a job in the laboratory at Christie Cancer Hospital in Manchester through her father's climber and friend, the biochemist Raymond Clayton . For two years she was able to deal with the estrogen dependence in the development of breast cancer before starting her doctorate in chemical pathology at the University of Manchester .

Her research on the hormone aldosterone led to a grant from the National Institutes of Health to the Worcester Foundation for Experimental Biology in Shrewsbury , Massachusetts. There, researchers worked on oral contraceptives and methods of in vitro fertilization , among them her future laboratory assistant Mika Hayano (1920–1964), who died of breast cancer after conventional treatment, and the chemist Harry Brodie, whom she married soon afterwards. Her two sons were born in quick succession and Brodie worked part-time in her husband's laboratory, with whom she researched aromatase, a key enzyme in the body's own production of estrogen . As early as the early 1970s, Angela Brodie began - initially together with her husband - to develop a new approach to curb the formation of estrogen. She was looking for a clinically useful link between the knowledge about estrogen biosynthesis and the needs of breast cancer patients like Mika Hayano. Encouraged by molecular biologist and feminist Joy Hochstadt, although she only worked part-time, she submitted an application for financial aid, which was approved. Angela Brodie continued her research at the Worcester Foundation for another 18 years, developing aromatase inhibitors and demonstrating their clinical efficacy in model systems.

In June 2005, Angela Brodie was the first woman - and at the same time the last recipient - to be awarded the prestigious Charles F. Kettering Prize of the General Motors Cancer Research Foundation , which has been awarded annually since 1979 for special achievements in the field of cancer research , for her pioneering work in the development of aromatase inhibitors . The international award was endowed with 250,000 US dollars.

In 2010 she was awarded the Gabbay Award and in 2011 the Pasarow Award . In 2012 she also received the ASPET Award from the American Society for Pharmacology and Experimental Therapeutics .

Fonts

  • Recent advances in steroid biochemistry and molecular biology. proceedings of the Third International Aromatase Conference: Basic and Clinical Aspects of Aromatase. Bologna, Italy, 14.-17. June 1992. Pergamon Press, Oxford et al. a. 1993, pp. 321-696.
  • Aromatase inhibitors in the treatment of advanced breast cancer. ( Seminars in Oncology , 23.4, Suppl. 9) Saunders, Philadelphia 1996.
  • Proceedings of the VIII. International Aromatase Conference "Aromatase 2006". Baltimore, Maryland, USA, 18-20. September, 2006. Elsevier, Amsterdam a. a. 2006.

literature

  • Balkees Abderrahman and V. Craig Jordan: Angela M. Hartley Brodie (1934-2017). In: Nature . Volume 548, 2017, p. 32, doi: 10.1038 / 548032a

Web links

Individual evidence

  1. ↑ a b c A Class Above: Dr. Angela Brodie wins the 2005 Kettering Prize. Dr. Brodie is the first woman to receive this international honor. In: medicalalumni.org. Retrieved October 6, 2013.
  2. ^ Adam Bernstein: Angela Brodie, scientist who helped make major advances in breast cancer treatment, dies at 82. In: The Washington Post . Angela Brodie, scientist who helped make major advances in breast cancer treatment, dies at 82, June 8, 2017, accessed June 9, 2017 .
  3. ^ University of Maryland Scientist to Receive 2005 Charles F. Kettering Prize for Cancer Research on the University of Maryland platform, accessed October 6, 2013.
  4. ↑ On the award of the Charles F. Kettering Prize. In: umgcc.org. Retrieved October 6, 2013.
  5. ↑ Angela M. Hartley Brodie, Ph.D., Is Recipient of 2012 Pharmacia-ASPET Award. From the University of Maryland platform, accessed October 10, 2013.
personal data
SURNAME Brodie, Angela Hartley
ALTERNATIVE NAMES Brodie, Angela; Brodie, Angela M. Hartley; Hartley, Angela (maiden name)
BRIEF DESCRIPTION American pharmacologist
DATE OF BIRTH September 28, 1934
PLACE OF BIRTH Oldham , England , UK
DATE OF DEATH June 7, 2017
Place of death Fulton , Howard County , Maryland , United States