David M. Blow

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David Mervyn Blow (born June 27, 1931 in Birmingham , † June 8, 2004 in Appledore , North Devon near Bideford ) was a British biophysicist . He is known for developing the X-ray structure studies of proteins.

Blow, the son of a Methodist minister who worked as a missionary in Madras , attended school in Bath and studied at Cambridge University (Corpus Christi College).

In his dissertation with Max Perutz at the Cavendish Laboratory , he developed the algorithm in X-ray crystallography (method of isomorphic replacement), which was later named after him and Francis Crick .

After two years in the USA at the Massachusetts Institute of Technology with Alexander Rich (* 1924) and the National Institutes of Health , he was back in Cambridge in Perutz's group. There he and Michael Rossmann developed the molecular replacement method , which they also applied to the hemoglobin investigated by Max Perutz and John Kendrew . Among other things, Blow clarified the structure of alpha-chymotrypsin (1964).

In 1977 he became professor of biophysics at Imperial College London . From 1981 to 1984 he was dean and from 1991 to 1994 head of the physics faculty.

1972 Blow became a Fellow of the Royal Society . In 1979 he received the Prix ​​Charles-Léopold Mayer , and in 1987 the Wolf Prize in Chemistry with David C. Phillips . He was a co-founder of the British Crystallographic Association and its president from 1986 to 1988.

Blow had been married since 1955 and had two children. Although not a smoker himself, he died of lung cancer.

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