Samuel Danishefsky

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Samuel Joseph Danishefsky (born March 10, 1936 in Bayonne , New Jersey ) is an American chemist.

life and work

Samuel Danishefsky received his bachelor's degree in chemistry from Yeshiva University in 1956 . In 1962, he was with Peter Yates with the theme rearrangement of diazo derivative of the bicyclo (2.2.1) heptane system at Harvard University as a doctor of chemistry doctorate . From 1961 to 1963 he was a post-doctoral student with Gilbert Stork at Columbia University . He then moved to the University of Pittsburgh , where he worked his way up from assistant professor (1964-68) to associate professor (1968-71) and professor (1971-79) to university professor (1978-79). From 1979 to 1993 he was a professor at Yale University , where he was also dean of the chemistry faculty from 1981 to 1987, Eugene Higgins professor from 1983 to 1989 and Sterling Professor from 1989 to 1993 . Since 1991 Danishefsky has been director of the Bioorganic Chemistry Laboratory at Memorial Sloan-Kettering Cancer Center , New York. Since 1993 he has also held the Eugene W. Kettering Chair at the Sloan-Kettering Institute for Cancer Research and a chemistry professorship at Columbia University.

Danishefsky works on the development of new synthetic methods in organic chemistry . He is pursuing two directions in particular: First, the synthesis of small, clinically useful molecules that are to be used, for example, in the treatment of cancer , Alzheimer's , Huntington's and Parkinson's . He starts with natural, biologically active molecules, removes side branches and manipulates functional groups in order to obtain substances with higher effectiveness and improved pharmacological properties. The second thrust of his research is the synthesis of carbohydrate-based tumor antigens . To do this, he creates complex oligosaccharides , glycoconjugates and glycopeptides .

Awards (selection)

Memberships

See also

literature

Web links

Individual evidence

  1. ^ Biographical data, publications and academic family tree of Samuel J. Danishefsky at academictree.org, accessed on January 29, 2018.
personal data
SURNAME Danishefsky, Samuel
ALTERNATIVE NAMES Danishefsky, Samuel J .; Danishefsky, Samuel Joseph (full name)
BRIEF DESCRIPTION American chemist
DATE OF BIRTH March 10, 1936
PLACE OF BIRTH Bayonne , New Jersey , USA