Harold Edwin Umbarger

Harold Edwin Umbarger (born July 17, 1921 in Shelby , Ohio , † November 15, 1999 in Carmel , Indiana ) was an American biochemist .

Umbarger was considered a leader in the field of the biosynthesis of amino acids in bacteria . He was best known for his discovery of feedback inhibition ( negative feedback ) in enzymology .

Umbarger earned a bachelor's degree from Ohio University in Athens in 1943 and a master's degree there in 1944 . In 1950 he earned a Ph.D. from Harvard University in Cambridge , Massachusetts , with his thesis Studies on the Interactions Involved in the Biosynthetic Mechanisms of Isoleucine and Valine in Escherichia Coli. in bacteriology and immunology . His studies were interrupted by military service on the USS Rescue from 1944 to 1946 . Umbarger stayed as a postdoctoral fellow at Harvard University, where he also became an assistant professor . In 1960 he moved to the Cold Spring Harbor Laboratory in Cold Spring Harbor , New York , before receiving a professorship at Purdue University in West Lafayette , Indiana in 1964 .

After the death of his first wife in 1993, with whom he had three daughters, Umbarger remarried in 1995.

Awards (selection)

• 1963 Guggenheim Fellowship
• 1971 member of the American Academy of Arts and Sciences
• 1975 Rosenstiel Award , together with Arthur B. Pardee
• 1976 member of the National Academy of Sciences

At Purdue University there is the H. Edwin Umbarger Distinguished Professor of Genetics ( endowed professorship ), the current holder (as of 2012) is Stanton B. Galvin , whose predecessor was Jeffrey Bennetzen .

literature

• Nicole Kresge, Robert D. Simoni, Robert L. Hill: H. Edwin Umbarger's Contributions to the Discovery of Feedback Inhibition. In: The Journal of Biological Chemistry Vol. 280, No. 52, December 30, 2005, p. E49 (PDF, 34 kB)

Individual evidence

1. ↑ Mansfield News Journal , November 17, 1999, quoted in Obituaries & Death Notices: U at ancestry.com; Retrieved May 28, 2012
2. ^ Harvard University. Report of the President of Harvard College and reports of departments. ( Memento from July 16, 2012 in the web archive archive.today )
3. ^ John Simon Guggenheim Foundation - H. Edwin Umbarger. In: gf.org. Retrieved February 12, 2016 . 
4. ↑ Book of Members 1780 – present, Chapter U. (PDF; 58 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved May 3, 2020 . 
5. ^ Past Winners - Rosenstiel Award - Rosenstiel Basic Medical Sciences Research Center - Brandeis University. In: brandeis.edu. Retrieved January 23, 2016 .