Orthomyxoviridae

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Orthomyxoviridae
Influenza virus.png

Influenza virus in the TEM

Systematics
Classification : Viruses
Area : Riboviria
Empire : Orthornavirae
Phylum : Negarnaviricota
Subphylum : Polyploviricotina
Class : Insthoviricetes
Order : Articulavirales
Family : Orthomyxoviridae
Taxonomic characteristics
Genome : (-) ssRNA segmented
Baltimore : Group 5
Symmetry : helical
Cover : available
Scientific name
Orthomyxoviridae
Left

The family Orthomyxoviridae ( Greek μύξα myxa , German 'slime' ) comprises enveloped viruses with single-stranded RNA with negative polarity as the genome . Their RNA genome is distributed over several segments, which is why, in contrast to the Paramyxoviridae, they are not assigned to the order Mononegavirales . The segmentation of their genome allows the Orthomyxoviridae a high genetic flexibility and adaptability to new host species due to the mixing of the different segments of different subtypes and mutants by the so-called reassortment .

The Orthomyxoviridae include virus genera that mainly infect the respiratory system of a host via droplet infection and multiply therein. This applies in particular to the genera of the influenza viruses , which can cause asymptomatic infections or serious illnesses in mammals and birds . Only the species of the genus Thogotovirus do not cause respiratory infections and are transmitted to vertebrates by ticks . Some aquatic hosts of the genera influenza virus A ( baleen whales ) and isavirus (salmon) are infected by contaminated water, direct contact or (in the case of the infectious salmon anemia virus ) by fish lice . The tilapia pond virus was also scientifically described as "orthomyxovirus-like" and placed by the ICTV in a new sister family Amnoonviridae , genus Tilapinevirus .

morphology

The virus particles (virions) of the Orthomyxoviridae are spherical to irregular and 80–120 nm in diameter. Thread-like (filamentous) shapes with lengths of up to a few µm are also observed. The lipid-containing virus envelope contains 1–3 glycoproteins and 1–2 non-glycosylated proteins. These form visible “spikes” on the surface that are 10–14 nm long and 4–6 nm in diameter. Anchored in the envelope, but with the greater part pointing inwards, are so-called matrix proteins that line the space between the envelope and the capsids (matrix space).
Depending on the segmentation of the genome, the virions also contain several helical capsids , at one end of which several subunits of the viral polymerase proteins (PA, PB1 and PB2) are associated. These viral enzymes show different activities depending on the virus genus, e.g. B. PB1 is an endonuclease in influenza viruses and also an
RNA polymerase (transcriptase) in these and the genus Thogotovirus . Once released in the cytoplasm, the capsids are transported into the cell nucleus by specific nuclear import .

The (-) ssRNA genome is linear and segmented; the number of segments varies between the genera. Thus, the species of the genera Influenzavirus A , Influenzavirus B and Isavirus each have 8 segments, Influenzavirus C and from the genus Thogotovirus the species Dhori virus 7, the species Thogoto virus 6 segments. The size of the segments ranges from 874 to 2396 nt , the total size of the genome from 10.0 to 14.6  kb . Due to distribution and synthesis errors during virus replication, many virions have shorter, defective RNA pieces or do not have a complete set of segments. This is particularly observed in the case of mutations in the polymerase subunit PA, which apparently plays a decisive role in the correct packaging and distribution of the genome segments.

Systematics

Phylogenetic tree of the Orthomyxoviridae with confirmed and proposed representatives (black and red, respectively)

As of March 2019, the systematics of the Orthomyxoviridae according to the International Committee on Taxonomy of Viruses (ICTV) is as follows:

  • Family Orthomyxoviridae
  • Species of Salmon Infectious Anemia Virus (officially Salmon isavirus )

The individual virus lines and other unclassified candidates can be found at the NCBI.

literature

  • CM Fauquet, MA Mayo, et al. : Eighth Report of the International Committee on Taxonomy of Viruses. London, San Diego 2005.
  • RA Lamb, CM Horvath: Orthomyxoviridae - The viruses and Their Replication. In: David M. Knipe, Peter M. Howley et al. (Ed.): Fields' Virology. 4th edition. Philadelphia 2001.

Web links

swell

  1. a b ICTV: Master Species List 2018b.v2 , MSL # 34v, March 2019
  2. a b ICTV: ICTV Taxonomy history: Akabane orthobunyavirus , EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL # 35)
  3. ^ WR Kaufman, PA Nuttall: Rhipicephalus appendiculatus (Acari: Ixodidae): dynamics of Thogoto virus infection in female ticks during feeding on guinea pigs. Experimental Parasitology. 104 (1-2), May-June 2003, pp. 20-25.
  4. J. Mandler, OT Gorman, S. Ludwig, E. Schroeder, WM Fitch, RG Webster , C. Scholtissek: Derivation of the nucleoproteins (NP) of influenza A viruses isolated from marine mammals. Virology. 176 (1), May 1990, pp. 255-261.
  5. Eran Bacharach et al. : Characterization of a Novel Orthomyxo-like Virus Causing Mass Die-Offs of Tilapia. In: mBio. Volume 7, No. 2, e00431-16, 2016, doi: 0.1128 / mBio.00431-16
  6. G. Kochs, O. Haller: Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. PNAS 96 (5), March 2, 1999, pp. 2082-2086.
  7. ^ JF Regan, Y. Liang, TG Parslow: Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA. Journal of Virology. 80 (1), Jan 2006, pp. 252-261. PMID 16352550 .
  8. NCBI: Orthomyxoviridae (family)