Prosulfuron

Structural formula
General
Surname	Prosulfuron
other names	N - [(4-Methoxy-6-methyl-1,3,5-triazin-2-yl) carbamoyl] -2- (3,3,3-trifluoropropyl) benzenesulfonamide ( IUPAC )
Molecular formula	C 15 H 16 F 3 N 5 O 4 S
Brief description	beige solid
External identifiers / databases
CAS number 94125-34-5 ECHA InfoCard 100.130.222 PubChem 91751 ChemSpider 82849 Wikidata Q22808801
properties
Molar mass	419.13 g mol −1
Physical state	firmly
Melting point	155 ° C
solubility	poor solubility in water
safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary Caution H and P phrases H: 302-410 P: 273-301 + 312 + 330
Toxicological data	986 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Prosulfuron is a chemical compound from the group of sulfonylureas . It is used as a herbicide in agriculture . Syngenta products containing the active ingredient are available in Germany.

use

Products with the active ingredient prosulfuron are used in agriculture . It is suitable for combating broad-leaved weeds in maize cultivation, as it is insensitive to prosulfuron. In contrast, the cultivated plants oilseed rape , sunflowers and Fabaceaen show a high sensitivity, so that they are not suitable for treatment with prosulfuron.

In addition, care must be taken to ensure that prosulfuron does not get into water because of its high toxicity to fish and algae.

effect

Prosulfuron one of the group of ALS - inhibitor B. It is on the leaves and roots added the weeds. After absorption, prosulfuron is transported via the vascular bundles until it reaches its destination, the meristematic tissue . Prosulfuron inhibits the enzyme acetolactate synthase, which enzymatically catalyzes chemical reactions within various metabolic pathways . The inhibition has the consequence that the amino acids valine , leucine and isoleucine can no longer be synthesized by the affected tissues. Sensitive weeds react to this with growth stoppage and then die off after they have turned red or yellow.

Admission

Prosulfuron has been approved in the EU since July 1, 2002 .

Individual evidence

1. ↑ ^{a b c d e} Entry on prosulfuron in the GESTIS substance database of the IFA , accessed on January 15, 2020(JavaScript required) .
2. ↑ Data prosulfuron at Sigma-Aldrich , accessed on 11 January 2018 ( PDF ).
3. ↑ Entry on Prosulfuron (ISO) in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 12, 2018. Manufacturers or distributors can expand the harmonized classification and labeling .
4. ↑ Safety data sheet in accordance with Regulation (EC) No. 1907/2006. (PDF) (No longer available online.) Syngenta, formerly in the original ; accessed on January 13, 2018 .  ( Page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.    
5. ↑ List of approved plant protection products from the Federal Office for Consumer Protection and Food Safety , last accessed on January 11, 2018.
6. ↑ ^{a b c} PEAK® product information sheet. (PDF) (No longer available online.) Syngenta, formerly in the original ; accessed on January 13, 2018 .  ( Page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.    
7. ↑ M. Schulte: Transgenic herbicide-resistant cultures. Reviews and prospects after 8 years of international cultivation practice . In: Healthy plants, Springer-Verlag, 2015, DOI: 10.1007 / s10343-005-0066-y , p. 42.
8. ↑ Hans-Walter Heldt, Birgit Piechulla: Plant biochemistry . Springer-Verlag Berlin Heidelberg, 2015, DOI: 10.1007 / 978-3-662-44398-9 , pp. 281-283.
9. ↑ General Directorate Health and Food Safety of the European Commission: Entry on prosulfuron in the EU pesticide database; Entry in the national list of plant protection products in Germany ; accessed on January 11, 2018.
10. ↑ Implementing Regulation (EU) No. 540/2011 of the Commission of 25 May 2011 for the implementation of Regulation (EC) No. 1107/2009 of the European Parliament and of the Council with regard to the list of approved active substances , accessed on January 13, 2018 , p. 10.