Ralf Bartenschlager

Ralf Bartenschlager (born May 29, 1958 in Mannheim ) is a German virologist and professor at the Ruprecht-Karls-Universität Heidelberg .

Live and act

Bartenschlager grew up in simple circumstances with his grandparents in a working-class suburb of Mannheim. After graduating from high school, he worked as a police officer for four years. He began studying biology at Heidelberg University in 1981. In 1987 he finished his studies. In 1990 he did his doctorate with Heinz Schaller at the Center for Molecular Biology in Heidelberg on the topic of structural and functional characterization of the P protein in hepatitis B viruses . For his doctoral thesis he was awarded the "Prize for the best dissertation of the Society for Molecular Biological Research Heidelberg". First he worked as a postdoctoral fellow at the University of Heidelberg until 1991 , until he then switched to the pharmaceutical company Hoffmann-La Roche , which is based in Basel. He worked for the pharmaceutical company until 1993. There he began his scientific studies on Hepatitis C - Virus .

At the Johannes Gutenberg University Mainz habilitation he 1999. His professorial dissertation had the studies on the molecular biology of the hepatitis C virus - implications for the development of antiviral therapy concepts on the subject. He then became a group leader at the Institute of Virology.

Since 2002 he has been a professor at the Ruprecht-Karls-Universität in Heidelberg. There he heads the "Molecular Virology" department at the Center for Infectious Diseases. Between 2002 and 2012 he received an endowed professorship from the Chica and Heinz Schaller Foundation .

Since 2005 he has been a member of the scientific advisory board of the Society for Virology . Between 2009 and 2015 he was also a member of the specialist college for virology of the German Research Foundation . Since 2013 he has been a member of the advisory board of the European Society for Virology and is co-coordinator of the "TTU Hepatitis" at the German Center for Infection Research .

At the German Cancer Research Center , he has headed the “Virus ‐ Associated Carcinogenesis” department since 2014 and is spokesperson for the research focus “Infection, Inflammation and Cancer”.

Research priorities

Bartenschlager's research focuses primarily on the hepatitis C virus , but also the hepatitis B virus . These viruses are among the main pathogens in acute and chronic liver diseases and are strongly associated with the development of liver cancer . In addition, Bartenschlager is still working on flaviviruses , especially the dengue virus , the cause of dengue fever . With the hepatitis viruses as well as with the dengue virus, he made important contributions to the understanding of the life cycles of the viruses. His pioneering work on the intracellular replication of the hepatitis C virus and the development of an experimental system ( replicon system) that allows virus genomes to be replicated in cell culture are considered to be the key foundations for the development of completely new classes of highly effective drugs against hepatitis C. . In recognition of this achievement, he was awarded the prestigious Robert Koch Prize (together with Charles M. Rice) in 2015.

Awards and memberships

In 2000, the city of Clausthal-Zellerfeld awarded him the Robert Koch Prize of the Bergstadt Clausthal-Zellerfeld, which was donated in honor of Robert Koch . This prize is endowed with 5000 euros and was launched in 1981 to promote medical-biological research.
In 2001 he was awarded the Loeffler Frosch Prize by the Society for Virology, which is awarded for special achievements in the field of virology.
In 2002 he was honored with the William Prusoff Young Investigator Lecture Award.
In 2006 he was invited by the Freiburg Medical Society to give a lecture in memory of Ludwig Aschoff ; This was accompanied by the award of the Aschoff Medal.
In 2006 he was awarded the Behring Lecture by the Philipps University of Marburg ; With this award, the university honors scientists who have made outstanding contributions in the field of immunology , virology or microbiology . Seven years later he was awarded the lucrative Lautenschläger Research Prize by the University of Heidelberg .
In 2006 Bartenschlager was elected a member of the German Academy of Sciences Leopoldina .
Together with Charles M. Rice , he was awarded the Robert Koch Prize in 2015.
In 2016 Bartenschlager, Rice and Michael J. Sofia received the Lasker ~ DeBakey Clinical Medical Research Award .
In 2017 he received the Hector Science Award and was elected to the European Molecular Biology Organization .
In 2019 Bartenschlager was awarded the Prince Mahidol Prize .

Fonts (selection)

Structural and functional characterization of the P protein of the hepatitis B viruses . sn, sl 1990, OCLC 75195168 (Heidelberg, University, dissertation, 1990).
Studies on the molecular biology of the hepatitis C virus. Implications for the development of antiviral therapy concepts . sn, sl 1998, OCLC 614148436 (Mainz, University, habilitation paper, 1998).
as editor with Hans-Georg Kräusslich : Antiviral strategies (= Handbook of Experimental Pharmacology . Volume 189 ). Springer, Berlin et al. 2009, ISBN 978-3-540-79086-0 .
as editor: Hepatitis C virus. From molecular virology to antiviral therapy (= Current Topics in Microbiology and Immunology . Volume 369 ). Springer, Heidelberg et al. 2013, ISBN 978-3-642-27340-7 .

Web links

Literature by and about Ralf Bartenschlager in the bibliographic database WorldCat

Individual evidence

↑ Curriculum vitae: Prof. Dr. Ralf Bartenschlager. (PDF) In: cellnetworks.uni-hd.de. Retrieved June 25, 2015 .
↑ Bartenschlager's autobiographical notes on the occasion of the presentation of the Lasker Awards
↑ ^a ^b ^c ^d Curriculum Vitae Prof. Dr. Ralf Bartenschlager. (PDF) Retrieved June 23, 2015 .
^ DZIF: Prize winners without airs. In: dzif.de. Retrieved June 25, 2015 .
↑ ^a ^b résumé of Ralf Bartenschlager. (PDF) Retrieved June 23, 2015 .
↑ Previously funded professorships. In: chs-stiftung.de. Retrieved June 25, 2015 .
↑ Review boards of the German Research Foundation. In: dfg.de. Retrieved June 23, 2015 .
↑ DZIF: Hepatitis. Retrieved June 25, 2015 .
^ Robert Koch Foundation - Promotion Prize of the City of Clausthal-Zellerfeld. In: robert-koch-stiftung.de. Retrieved June 23, 2015 .
^ Loeffler Frosch Prize of the Society for Virology eV (GfV) | Society for Virology eV In: gfv.org. Retrieved June 25, 2015 .
^ ISAR Awards - International Society for Antiviral Research. In: wisar-icar.com. Retrieved June 25, 2015 .
↑ Aschoff Medal to Professor Dr. Ralf Bartenschlager - Public Relations and Relationship Management. In: pr.uni-freiburg.de. Retrieved June 25, 2015 .
^ Behring Lecture Prize - Philipps University of Marburg. In: uni-marburg.de. Retrieved June 25, 2015 .
^ Björn Bertram: Lautenschläger Research Award - Heidelberg University. In: lautenschlaeger-forschungspreis.uni-hd.de. Retrieved June 25, 2015 .
↑ Birgit Sommer: Heidelberg virologist Ralf Bartenschlager receives Lautenschläger Prize. In: rnz.de. Retrieved June 30, 2015 .
↑ Member entry by Prof. Dr. Ralf Bartenschlager (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on June 6, 2016.
^ Robert Koch Foundation - Ralf Bartenschlager. In: robert-koch-stiftung.de. Retrieved June 25, 2015 .
^ German Cancer Research Center: Ralf Bartenschlager awarded the Robert Koch Prize. In: dkfz.de. Retrieved June 25, 2015 .
^ Robert Koch Prize for Ralf Bartenschlager. In: leopoldina.org. Retrieved June 25, 2015 .
^ Lasker Prize for Ralf Bartenschlager (report from the German Cancer Research Center). In: dkfz.de. Retrieved September 14, 2015 .
^ Lasker Prize for Ralf Bartenschlager (report from Heidelberg University Hospital). In: klinikum.uni-heidelberg.de. Retrieved September 14, 2015 .

personal data
SURNAME	Bartenschlager, Ralf
BRIEF DESCRIPTION	German virologist and professor at Heidelberg University
DATE OF BIRTH	May 29, 1958
PLACE OF BIRTH	Mannheim

[1] Curriculum vitae: Prof. Dr. Ralf Bartenschlager. (PDF) In: cellnetworks.uni-hd.de. Retrieved June 25, 2015 .

[2] Bartenschlager's autobiographical notes on the occasion of the presentation of the Lasker Awards

[Leopoldina-3] Curriculum Vitae Prof. Dr. Ralf Bartenschlager. (PDF) Retrieved June 23, 2015 .

[4] DZIF: Prize winners without airs. In: dzif.de. Retrieved June 25, 2015 .

[Lebenslauf-5] résumé of Ralf Bartenschlager. (PDF) Retrieved June 23, 2015 .

[6] Previously funded professorships. In: chs-stiftung.de. Retrieved June 25, 2015 .

[7] Review boards of the German Research Foundation. In: dfg.de. Retrieved June 23, 2015 .

[8] DZIF: Hepatitis. Retrieved June 25, 2015 .

[9] Robert Koch Foundation - Promotion Prize of the City of Clausthal-Zellerfeld. In: robert-koch-stiftung.de. Retrieved June 23, 2015 .

[10] Loeffler Frosch Prize of the Society for Virology eV (GfV) | Society for Virology eV In: gfv.org. Retrieved June 25, 2015 .

[11] ISAR Awards - International Society for Antiviral Research. In: wisar-icar.com. Retrieved June 25, 2015 .

[12] Aschoff Medal to Professor Dr. Ralf Bartenschlager - Public Relations and Relationship Management. In: pr.uni-freiburg.de. Retrieved June 25, 2015 .

[13] Behring Lecture Prize - Philipps University of Marburg. In: uni-marburg.de. Retrieved June 25, 2015 .

[14] Björn Bertram: Lautenschläger Research Award - Heidelberg University. In: lautenschlaeger-forschungspreis.uni-hd.de. Retrieved June 25, 2015 .

[15] Birgit Sommer: Heidelberg virologist Ralf Bartenschlager receives Lautenschläger Prize. In: rnz.de. Retrieved June 30, 2015 .

[16] Member entry by Prof. Dr. Ralf Bartenschlager (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on June 6, 2016.

[17] Robert Koch Foundation - Ralf Bartenschlager. In: robert-koch-stiftung.de. Retrieved June 25, 2015 .

[18] German Cancer Research Center: Ralf Bartenschlager awarded the Robert Koch Prize. In: dkfz.de. Retrieved June 25, 2015 .

[19] Robert Koch Prize for Ralf Bartenschlager. In: leopoldina.org. Retrieved June 25, 2015 .

[20] Lasker Prize for Ralf Bartenschlager (report from the German Cancer Research Center). In: dkfz.de. Retrieved September 14, 2015 .

[21] Lasker Prize for Ralf Bartenschlager (report from Heidelberg University Hospital). In: klinikum.uni-heidelberg.de. Retrieved September 14, 2015 .