Charles M. Rice

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Charles Moen Rice III (born August 25, 1952 in Sacramento ) is an American virologist , professor and head of the laboratory for virology and infectious diseases at Rockefeller University . He is one of the leading scientists in the field of Flaviviridae viruses, which also include the hepatitis C virus . In 2020 he was awarded the Nobel Prize in Physiology or Medicine .

Live and act

Rice was born in Sacramento, California , in 1952 to an insurance clerk and housewife . He began studying veterinary medicine at the University of California, Davis . During a basic course in biology, his later mentor David Barrett drew Rice's attention to the field of science, and Rice did a chemistry internship to study the way sea ​​squirts can filter large amounts of vanadium from seawater. At Barrett's suggestion, he attended a physiology course at the Marine Biological Laboratory , where he was able to gain initial laboratory experience in the field of biophysics and chemistry. He liked this experience so much that after completing his bachelor's degree in zoology from the University of California in 1974, he returned to the Marine Biological Laboratory as a teaching assistant for a year.

In the fall of 1975 he enrolled in the graduate program in biochemistry at the California Institute of Technology (Caltech), where he received his PhD in 1981 . His dissertation was entitled Studies on the structure proteins of Sindbis virus . He stayed at Caltech for another four years , where he worked as a postdoctoral fellow . Rice worked in James Strauss's laboratory, which studied the replication of RNA viruses in their hosts.

A year later, in 1986, he became a faculty member at Washington University in St. Louis , where he remained until 2000. There he and his team researched, among other things, the biogenesis and structure of proteins encoded by the hepatitis C virus .

In 2000, Rice moved to Rockefeller University, where she has held the Maurice R. and Corinne P. Greenberg Chair in Virology ever since. He is also head of the laboratory for virology and infectious diseases. Rice is the Scientific Director and General Manager of the Center of the Study of Hepatitis-C . This center was founded by Rockefeller University, Weill Cornell Medical College, and NewYork-Presbyterian Hospital . He was President of the American Society for Virology from 2002 to 2003 .

Rice has published more than 250 scientific articles along with fellow scientists and is the past editor of the Journal of Virology .

Awards and memberships

Rice is a Fellow of the American Association for the Advancement of Science (AAAS), a member of the National Academy of Sciences (NAS), and was President of the American Society of Virology (AVS). In 2015 Rice was awarded the Robert Koch Prize together with Ralf Bartenschlager from Heidelberg University . The Robert Koch Foundation justified its decision by saying that Rice contributed to

"Identify [...] antiviral targets and establish virus replication in cell culture systems for basic research and for drug - screening can be used and test systems."

His research to understand the structure of the HCV virus, the production of the first infectious clone of the virus and the setting up of animal models mean that further studies can now take place to combat this virus.

For 2016 Rice was awarded the InBev-Baillet Latour Health Prize (Belgium) and (together with Ralf Bartenschlager and Michael J. Sofia ) the Lasker ~ DeBakey Clinical Medical Research Award .

In 2020 he received the Nobel Prize in Medicine , together with Harvey Alter and Michael Houghton , for the discovery of the hepatitis C virus.

Fonts (selection)

  • with Curt H. Hagedorn: The hepatitis C viruses (= Current Topics in Microbiology and Immunology. 242). Springer, Berlin et al. 2000, ISBN 3-540-65358-9 .
  • as editor with Raymond F. Schinazi and Jean-Pierre Sommadossi: Frontiers in viral hepatitis. Elsevier, Amsterdam et al. 2003, ISBN 0-444-50986-0 .

Individual evidence

  1. ^ A b c d Prashant Nair: Profile of Charles M. Rice . In: Proceedings of the National Academy of Sciences . tape 108 , no. 21 , May 24, 2011, p. 8541-8543 , doi : 10.1073 / pnas.1105050108 .
  2. ↑ a b The Nobel Prize in Physiology or Medicine 2020 . In: nobelprize.org, October 5, 2020).
  3. ↑ Doctoral thesis with full name
  4. ^ A b The Rockefeller University - Charles M. Rice. In: Rockefeller University website. Retrieved August 16, 2015 .
  5. ^ The Rockefeller University - Members of the Virology and Infectious Disease Laboratory. In: Rockefeller University website. Retrieved August 16, 2015 .
  6. ^ A b Robert Koch Foundation - Charles M. Rice. In: Website of the Robert Koch Foundation. Retrieved August 16, 2015 .
  7. ↑ a b c CV of Charles M. Rice. (PDF) In: Website of the Robert Koch Foundation. Retrieved August 16, 2015 .
  8. ^ The Rockefeller University - Lab Members: Charles M. Rice. In: rockefeller.edu. Retrieved April 4, 2018 .
personal data
SURNAME Rice, Charles M.
ALTERNATIVE NAMES Rice III, Charles Moen
BRIEF DESCRIPTION American virologist
DATE OF BIRTH August 25, 1952
PLACE OF BIRTH Sacramento , USA