Concentrative nucleoside transporter 2: Difference between revisions

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{{Short description|Protein found in humans}}
{{PBB|geneid=9153}}
{{Infobox_gene}}
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'''Sodium/nucleoside cotransporter 2''' is a [[protein]] that in humans is encoded by the ''SLC28A2'' [[gene]].<ref name="pmid9435697">{{cite journal | author = Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM | title = Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization | journal = Am J Physiol | volume = 273 | issue = 6 Pt 2 | pages = F1058-65 | year = 1998 | month = Feb | pmid = 9435697 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9153| accessdate = }}</ref>


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'''Concentrative nucleoside transporter 2''' ('''CNT2''') is a [[protein]] that in humans is encoded by the ''SLC28A2'' [[gene]].<ref name="pmid9435697">{{cite journal | vauthors = Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM | title = Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization | journal = Am J Physiol | volume = 273 | issue = 6 Pt 2 | pages = F1058-65 |date=Feb 1998 | pmid = 9435697 | doi = 10.1152/ajprenal.1997.273.6.F1058}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9153}}</ref>
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==See also==
== See also ==
* [[Concentrative nucleoside transporter]]s
* [[Nucleoside transporter]]s
* [[Solute carrier family]]
* [[Solute carrier family]]


==References==
== References ==
{{reflist}}
{{Reflist|2}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{PBB_Further_reading
*{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
| citations =
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | vauthors=Ritzel MW, Yao SY, Ng AM |title=Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. |journal=Mol. Membr. Biol. |volume=15 |issue= 4 |pages= 203–11 |year= 1999 |pmid= 10087507 |doi=10.3109/09687689709044322 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | vauthors=Loewen SK, Ng AM, Yao SY |title=Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24475–84 |year= 1999 |pmid= 10455109 |doi=10.1074/jbc.274.35.24475 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Ritzel MW, Yao SY, Ng AM, ''et al.'' |title=Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. |journal=Mol. Membr. Biol. |volume=15 |issue= 4 |pages= 203–11 |year= 1999 |pmid= 10087507 |doi=10.3109/09687689709044322 }}
*{{cite journal | vauthors=Pennycooke M, Chaudary N, Shuralyova I |title=Differential expression of human nucleoside transporters in normal and tumor tissue. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 3 |pages= 951–9 |year= 2001 |pmid= 11162617 |doi= 10.1006/bbrc.2000.4205 |display-authors=etal}}
*{{cite journal | author=Loewen SK, Ng AM, Yao SY, ''et al.'' |title=Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24475–84 |year= 1999 |pmid= 10455109 |doi=10.1074/jbc.274.35.24475 }}
*{{cite journal | vauthors=Li JY, Boado RJ, Pardridge WM |title=Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood–brain barrier. |journal=J. Pharmacol. Exp. Ther. |volume=299 |issue= 2 |pages= 735–40 |year= 2001 |pmid= 11602688 }}
*{{cite journal | author=Pennycooke M, Chaudary N, Shuralyova I, ''et al.'' |title=Differential expression of human nucleoside transporters in normal and tumor tissue. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 3 |pages= 951–9 |year= 2001 |pmid= 11162617 |doi= 10.1006/bbrc.2000.4205 }}
*{{cite journal | vauthors=Gerstin KM, Dresser MJ, Giacomini KM |title=Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 2 |pages= F344–9 |year= 2002 |pmid= 12110519 |doi= 10.1152/ajprenal.00274.2001 |s2cid=21332585 }}
*{{cite journal | author=Li JY, Boado RJ, Pardridge WM |title=Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood-brain barrier. |journal=J. Pharmacol. Exp. Ther. |volume=299 |issue= 2 |pages= 735–40 |year= 2001 |pmid= 11602688 |doi= }}
*{{cite journal | vauthors=Molina-Arcas M, Bellosillo B, Casado FJ |title=Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. |journal=Blood |volume=101 |issue= 6 |pages= 2328–34 |year= 2003 |pmid= 12411296 |doi= 10.1182/blood-2002-07-2236 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Gerstin KM, Dresser MJ, Giacomini KM |title=Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 2 |pages= F344–9 |year= 2002 |pmid= 12110519 |doi= 10.1152/ajprenal.00274.2001 }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal | author=Molina-Arcas M, Bellosillo B, Casado FJ, ''et al.'' |title=Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. |journal=Blood |volume=101 |issue= 6 |pages= 2328–34 |year= 2003 |pmid= 12411296 |doi= 10.1182/blood-2002-07-2236 }}
*{{cite journal | vauthors=Shin HC, Landowski CP, Sun D |title=Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 696–703 |year= 2003 |pmid= 12893280 |doi=10.1016/S0006-291X(03)01259-2 |display-authors=etal}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors=Lang TT, Young JD, Cass CE |title=Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. |journal=Mol. Pharmacol. |volume=65 |issue= 4 |pages= 925–33 |year= 2004 |pmid= 15044622 |doi= 10.1124/mol.65.4.925 |s2cid=5665725 }}
*{{cite journal | author=Shin HC, Landowski CP, Sun D, ''et al.'' |title=Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 696–703 |year= 2003 |pmid= 12893280 |doi=10.1016/S0006-291X(03)01259-2 }}
*{{cite journal | vauthors=Damaraju VL, Visser F, Zhang J |title=Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 273–9 |year= 2005 |pmid= 15486050 |doi= 10.1124/mol.104.004408 |s2cid=3017992 |display-authors=etal}}
*{{cite journal | author=Lang TT, Young JD, Cass CE |title=Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. |journal=Mol. Pharmacol. |volume=65 |issue= 4 |pages= 925–33 |year= 2004 |pmid= 15044622 |doi= 10.1124/mol.65.4.925 }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
*{{cite journal | author=Damaraju VL, Visser F, Zhang J, ''et al.'' |title=Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 273–9 |year= 2005 |pmid= 15486050 |doi= 10.1124/mol.104.004408 }}
*{{cite journal | vauthors=Owen RP, Gray JH, Taylor TR |title=Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. |journal=Pharmacogenet. Genomics |volume=15 |issue= 2 |pages= 83–90 |year= 2005 |pmid= 15861032 |doi=10.1097/01213011-200502000-00004 |s2cid=12817964 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | vauthors=Owen RP, Badagnani I, Giacomini KM |title=Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 26675–82 |year= 2006 |pmid= 16840788 |doi= 10.1074/jbc.M513421200 |doi-access= free }}
*{{cite journal | author=Owen RP, Gray JH, Taylor TR, ''et al.'' |title=Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. |journal=Pharmacogenet. Genomics |volume=15 |issue= 2 |pages= 83–90 |year= 2005 |pmid= 15861032 |doi=10.1097/01213011-200502000-00004 }}
*{{cite journal | vauthors=Fernández-Veledo S, Jover R, Casado FJ |title=Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. |journal=Biochem. Biophys. Res. Commun. |volume=353 |issue= 2 |pages= 381–8 |year= 2007 |pmid= 17187757 |doi= 10.1016/j.bbrc.2006.12.021 |display-authors=etal}}
*{{cite journal | author=Owen RP, Badagnani I, Giacomini KM |title=Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 26675–82 |year= 2006 |pmid= 16840788 |doi= 10.1074/jbc.M513421200 }}
*{{cite journal | vauthors=Smith KM, Slugoski MD, Cass CE |title=Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. |journal=Mol. Membr. Biol. |volume=24 |issue= 1 |pages= 53–64 |year= 2007 |pmid= 17453413 |doi= 10.1080/09687860600942534 |s2cid=20779608 |display-authors=etal}}
*{{cite journal | author=Fernández-Veledo S, Jover R, Casado FJ, ''et al.'' |title=Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. |journal=Biochem. Biophys. Res. Commun. |volume=353 |issue= 2 |pages= 381–8 |year= 2007 |pmid= 17187757 |doi= 10.1016/j.bbrc.2006.12.021 }}
*{{cite journal | vauthors=Hirsh AJ, Stonebraker JR, van Heusden CA |title=Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. |journal=Biochemistry |volume=46 |issue= 36 |pages= 10373–83 |year= 2007 |pmid= 17696452 |doi= 10.1021/bi7009647 |display-authors=etal}}
*{{cite journal | author=Smith KM, Slugoski MD, Cass CE, ''et al.'' |title=Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. |journal=Mol. Membr. Biol. |volume=24 |issue= 1 |pages= 53–64 |year= 2007 |pmid= 17453413 |doi= 10.1080/09687860600942534 }}
*{{cite journal | vauthors=Li L, Tan CM, Koo SH |title=Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. |journal=Pharmacogenet. Genomics |volume=17 |issue= 9 |pages= 783–6 |year= 2007 |pmid= 17700367 |doi= 10.1097/FPC.0b013e3281c10e41 |display-authors=etal}}
*{{cite journal | author=Hirsh AJ, Stonebraker JR, van Heusden CA, ''et al.'' |title=Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. |journal=Biochemistry |volume=46 |issue= 36 |pages= 10373–83 |year= 2007 |pmid= 17696452 |doi= 10.1021/bi7009647 }}
*{{cite journal | author=Li L, Tan CM, Koo SH, ''et al.'' |title=Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. |journal=Pharmacogenet. Genomics |volume=17 |issue= 9 |pages= 783–6 |year= 2007 |pmid= 17700367 |doi= 10.1097/FPC.0b013e3281c10e41 }}
}}
{{refend}}
{{refend}}


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{{membrane-protein-stub}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
{{Purinergics}}

[[Category:Solute carrier family]]
[[Category:Solute carrier family]]



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Latest revision as of 08:13, 22 December 2023

SLC28A2
Identifiers
AliasesSLC28A2, CNT2, HCNT2, HsT17153, SPNT1, Concentrative nucleoside transporter 2, solute carrier family 28 member 2
External IDsOMIM: 606208 MGI: 1913105 HomoloGene: 20891 GeneCards: SLC28A2
Orthologs
SpeciesHumanMouse
Entrez

9153

269346

Ensembl

ENSG00000137860

ENSMUSG00000027219

UniProt

O43868

O88627

RefSeq (mRNA)

NM_004212

NM_172980
NM_001356532

RefSeq (protein)

NP_004203

NP_766568
NP_001343461
NP_001366388
NP_001366389

Location (UCSC)Chr 15: 45.25 – 45.28 MbChr 2: 122.43 – 122.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.[5][6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137860 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027219 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM (Feb 1998). "Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization". Am J Physiol. 273 (6 Pt 2): F1058-65. doi:10.1152/ajprenal.1997.273.6.F1058. PMID 9435697.
  6. ^ "Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2".

Further reading[edit]


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