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{{Short description|Protein found in humans}} |
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'''Solute carrier family 28 (sodium-coupled nucleoside transporter), member 1''', also known as '''SLC28A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9154| accessdate = }}</ref> |
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{{Infobox_gene}} |
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'''Concentrative nucleoside transporter 1''' ('''CNT1''') is a [[protein]] that in humans is encoded by the ''SLC28A1'' [[gene]].<ref name="pmid9124315">{{cite journal | vauthors = Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD | title = Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1) | journal = Am J Physiol | volume = 272 | issue = 2 Pt 1 | pages = C707–14 |date=Apr 1997 | pmid = 9124315 | doi = 10.1152/ajpcell.1997.272.2.C707}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9154}}</ref> |
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==See also== |
== See also == |
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* [[Concentrative nucleoside transporter]]s |
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* [[Nucleoside transporter]]s |
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* [[Solute carrier family]] |
* [[Solute carrier family]] |
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==References== |
== References == |
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{{ |
{{Reflist|2}} |
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==Further reading== |
== Further reading == |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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*{{cite journal | vauthors=Ritzel MW, Ng AM, Yao SY |title=Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). |journal=Mol. Membr. Biol. |volume=18 |issue= 1 |pages= 65–72 |year= 2001 |pmid= 11396613 |doi= 10.1080/09687680118530 |s2cid=218896128 |display-authors=etal}} |
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*{{cite journal | vauthors=Ritzel MW, Yao SY, Ng AM |title=Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. |journal=Mol. Membr. Biol. |volume=15 |issue= 4 |pages= 203–11 |year= 1999 |pmid= 10087507 |doi=10.3109/09687689709044322 |display-authors=etal|doi-access=free }} |
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| citations = |
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*{{cite journal | |
*{{cite journal | vauthors=Loewen SK, Ng AM, Yao SY |title=Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24475–84 |year= 1999 |pmid= 10455109 |doi=10.1074/jbc.274.35.24475 |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Mata JF, García-Manteiga JM, Lostao MP |title=Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. |journal=Mol. Pharmacol. |volume=59 |issue= 6 |pages= 1542–8 |year= 2001 |pmid= 11353816 |doi= 10.1124/mol.59.6.1542|display-authors=etal|hdl=10171/21116 |hdl-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Lai Y, Bakken AH, Unadkat JD |title=Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37711–7 |year= 2002 |pmid= 12097333 |doi= 10.1074/jbc.M204986200 |doi-access= free }} |
||
*{{cite journal | |
*{{cite journal | vauthors=Alcorn J, Lu X, Moscow JA, McNamara PJ |title=Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. |journal=J. Pharmacol. Exp. Ther. |volume=303 |issue= 2 |pages= 487–96 |year= 2002 |pmid= 12388627 |doi= 10.1124/jpet.102.038315 |s2cid=16195525 }} |
||
*{{cite journal | |
*{{cite journal | vauthors=Molina-Arcas M, Bellosillo B, Casado FJ |title=Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. |journal=Blood |volume=101 |issue= 6 |pages= 2328–34 |year= 2003 |pmid= 12411296 |doi= 10.1182/blood-2002-07-2236 |display-authors=etal|doi-access=free }} |
||
*{{cite journal | |
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=García-Manteiga J, Molina-Arcas M, Casado FJ |title=Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity. |journal=Clin. Cancer Res. |volume=9 |issue= 13 |pages= 5000–8 |year= 2004 |pmid= 14581375 |display-authors=etal}} |
||
*{{cite journal | |
*{{cite journal | vauthors=Loewen SK, Yao SY, Slugoski MD |title=Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes. |journal=Mol. Membr. Biol. |volume=21 |issue= 1 |pages= 1–10 |year= 2004 |pmid= 14668133 |doi= 10.1080/0968768031000140836 |s2cid=11973712 |display-authors=etal|doi-access=free }} |
||
*{{cite journal | |
*{{cite journal | vauthors=Gray JH, Mangravite LM, Owen RP |title=Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. |journal=Mol. Pharmacol. |volume=65 |issue= 3 |pages= 512–9 |year= 2004 |pmid= 14978229 |doi= 10.1124/mol.65.3.512 |s2cid=1788715 |display-authors=etal}} |
||
*{{cite journal | |
*{{cite journal | vauthors=Farré X, Guillén-Gómez E, Sánchez L |title=Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. |journal=Int. J. Cancer |volume=112 |issue= 6 |pages= 959–66 |year= 2004 |pmid= 15386342 |doi= 10.1002/ijc.20524 |s2cid=33828164 |display-authors=etal|doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Lai Y, Lee EW, Ton CC |s2cid=27633580 |title=Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively. |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 1 |pages= C39–45 |year= 2005 |pmid= 15456697 |doi= 10.1152/ajpcell.00192.2004 |display-authors=etal}} |
||
*{{cite journal | |
*{{cite journal | vauthors=Fernández-Veledo S, Jover R, Casado FJ |title=Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. |journal=Biochem. Biophys. Res. Commun. |volume=353 |issue= 2 |pages= 381–8 |year= 2007 |pmid= 17187757 |doi= 10.1016/j.bbrc.2006.12.021 |display-authors=etal}} |
||
*{{cite journal | |
*{{cite journal | vauthors=Slugoski MD, Loewen SK, Ng AM |title=Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling. |journal=Biochemistry |volume=46 |issue= 6 |pages= 1684–93 |year= 2007 |pmid= 17279631 |doi= 10.1021/bi061692s |display-authors=etal}} |
||
*{{cite journal | |
*{{cite journal | vauthors=Smith KM, Slugoski MD, Cass CE |title=Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. |journal=Mol. Membr. Biol. |volume=24 |issue= 1 |pages= 53–64 |year= 2007 |pmid= 17453413 |doi= 10.1080/09687860600942534 |s2cid=20779608 |display-authors=etal}} |
||
*{{cite journal | |
*{{cite journal | vauthors=Guallar JP, Cano-Soldado P, Aymerich I |title=Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. |journal=Antivir. Ther. (Lond.) |volume=12 |issue= 6 |pages= 853–63 |year= 2007 |doi=10.1177/135965350701200601 |pmid= 17926640 |s2cid=19447232 |display-authors=etal|doi-access=free }} |
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*{{cite journal | author=Slugoski MD, Loewen SK, Ng AM, ''et al.'' |title=Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling. |journal=Biochemistry |volume=46 |issue= 6 |pages= 1684–93 |year= 2007 |pmid= 17279631 |doi= 10.1021/bi061692s }} |
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*{{cite journal | author=Smith KM, Slugoski MD, Cass CE, ''et al.'' |title=Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. |journal=Mol. Membr. Biol. |volume=24 |issue= 1 |pages= 53–64 |year= 2007 |pmid= 17453413 |doi= 10.1080/09687860600942534 }} |
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*{{cite journal | author=Guallar JP, Cano-Soldado P, Aymerich I, ''et al.'' |title=Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. |journal=Antivir. Ther. (Lond.) |volume=12 |issue= 6 |pages= 853–63 |year= 2007 |pmid= 17926640 |doi= }} |
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}} |
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{{refend}} |
{{refend}} |
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⚫ | |||
{{Membrane transport proteins}} |
{{Membrane transport proteins}} |
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{{Purinergics}} |
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[[Category:Solute carrier family]] |
[[Category:Solute carrier family]] |
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Latest revision as of 00:19, 29 December 2023
SLC28A1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | SLC28A1, CNT1, HCNT1, Concentrative nucleoside transporter 1, solute carrier family 28 member 1, URCTU | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 606207; MGI: 3605073; HomoloGene: 37902; GeneCards: SLC28A1; OMA:SLC28A1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.[5][6]
See also[edit]
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000156222 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025726 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD (Apr 1997). "Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)". Am J Physiol. 272 (2 Pt 1): C707–14. doi:10.1152/ajpcell.1997.272.2.C707. PMID 9124315.
- ^ "Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1".
Further reading[edit]
- Ritzel MW, Ng AM, Yao SY, et al. (2001). "Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)". Mol. Membr. Biol. 18 (1): 65–72. doi:10.1080/09687680118530. PMID 11396613. S2CID 218896128.
- Ritzel MW, Yao SY, Ng AM, et al. (1999). "Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine". Mol. Membr. Biol. 15 (4): 203–11. doi:10.3109/09687689709044322. PMID 10087507.
- Loewen SK, Ng AM, Yao SY, et al. (1999). "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2". J. Biol. Chem. 274 (35): 24475–84. doi:10.1074/jbc.274.35.24475. PMID 10455109.
- Mata JF, García-Manteiga JM, Lostao MP, et al. (2001). "Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug". Mol. Pharmacol. 59 (6): 1542–8. doi:10.1124/mol.59.6.1542. hdl:10171/21116. PMID 11353816.
- Lai Y, Bakken AH, Unadkat JD (2002). "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies". J. Biol. Chem. 277 (40): 37711–7. doi:10.1074/jbc.M204986200. PMID 12097333.
- Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. S2CID 16195525.
- Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- García-Manteiga J, Molina-Arcas M, Casado FJ, et al. (2004). "Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity". Clin. Cancer Res. 9 (13): 5000–8. PMID 14581375.
- Loewen SK, Yao SY, Slugoski MD, et al. (2004). "Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes". Mol. Membr. Biol. 21 (1): 1–10. doi:10.1080/0968768031000140836. PMID 14668133. S2CID 11973712.
- Gray JH, Mangravite LM, Owen RP, et al. (2004). "Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations". Mol. Pharmacol. 65 (3): 512–9. doi:10.1124/mol.65.3.512. PMID 14978229. S2CID 1788715.
- Farré X, Guillén-Gómez E, Sánchez L, et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors". Int. J. Cancer. 112 (6): 959–66. doi:10.1002/ijc.20524. PMID 15386342. S2CID 33828164.
- Lai Y, Lee EW, Ton CC, et al. (2005). "Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively". Am. J. Physiol., Cell Physiol. 288 (1): C39–45. doi:10.1152/ajpcell.00192.2004. PMID 15456697. S2CID 27633580.
- Fernández-Veledo S, Jover R, Casado FJ, et al. (2007). "Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells". Biochem. Biophys. Res. Commun. 353 (2): 381–8. doi:10.1016/j.bbrc.2006.12.021. PMID 17187757.
- Slugoski MD, Loewen SK, Ng AM, et al. (2007). "Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling". Biochemistry. 46 (6): 1684–93. doi:10.1021/bi061692s. PMID 17279631.
- Smith KM, Slugoski MD, Cass CE, et al. (2007). "Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3". Mol. Membr. Biol. 24 (1): 53–64. doi:10.1080/09687860600942534. PMID 17453413. S2CID 20779608.
- Guallar JP, Cano-Soldado P, Aymerich I, et al. (2007). "Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients". Antivir. Ther. (Lond.). 12 (6): 853–63. doi:10.1177/135965350701200601. PMID 17926640. S2CID 19447232.