John A. Hardy

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John Anthony Hardy (* 9. November 1954 in Nelson , Lancashire ) is a British - American geneticist , molecular biologist and Alzheimer's Researchers at University College London .

Life

Hardy graduated in 1976 at Leeds University with a degree in biochemistry with the Bachelor from. In 1981 he obtained a Ph.D. from Imperial College London with Harry Bradford for his thesis On the Release of Amino Acod Neurotransmitters from Mammalian Synaptosomes. in neurochemistry .

As a postdoctoral fellow , Hardy worked for the Medical Research Council in the Department of Neuroendocrinology at the University of Newcastle upon Tyne , before receiving his first professorship ( Honorary Lecturer , comparable to Assistant Professor ) in Biochemistry at the University of Newcastle upon Tyne in 1982 . 1983/1984 Hardy worked as a lecturer in neuropathology at Umeå University in Sweden, before accepting a professorship in biochemistry again, this time at St Mary's Hospital in London , which merged with Imperial College London in 1987 . In 1989 Hardy received a position as Senior Lecturer (comparable to Associate Professor ) at Imperial College .

In 1992 Hardy went to the United States , where he took up a full professorship in Alzheimer's research at the University of South Florida at Tampa . In 1996 he moved to the Mayo Clinic in Jacksonville , Florida , as a professor of pharmacology and as a consultant . In 1999 he also took over the management of the neurosciences department there . In 2001, Hardy joined the National Institute on Aging (NIA, part of the National Institutes of Health , NIH, in Bethesda , Maryland ) as director of neurogenetics . At the same time he held a visiting professorship (honorary professor) for neuroscience at University College London .

In 2007 Hardy went back to England . He now accepted a full professorship at University College London, but initially retained a position at the NIA / NIH (Honorary Senior Scientist) .

Hardy is divorced and has three children.

Act

Hardy was able to make significant contributions to the understanding of the pathological processes in the brain of people with Alzheimer's disease . He also contributed to the understanding of other neurodegenerative diseases , such as Parkinson's disease , motor neuron diseases and synucleinopathies . Using methods such as whole genome sequencing , Hardy studies the complex interactions between genes and environmental conditions that increase the risk of neurodegenerative diseases.

Hardy discovered a mutation in the gene that codes for the amyloid precursor protein (APP). This mutation ensures that β-amyloid can be formed from the APP , which, according to the amyloid hypothesis co-founded by Hardy, is associated with Alzheimer's disease - and in particular the form with the early onset of the disease.

Hardy is one of the most cited Alzheimer's researchers worldwide.

Awards (selection)

Web links

literature

Individual evidence

  1. ^ John Hardy - Royal Society. In: royalsociety.org. Retrieved November 10, 2015 .
  2. ^ Dan David Prize: Laureates 2014 "Present - Combatting Memory Loss" John A. Hardy - The Dan David Prize. In: dandavidprize.org. Retrieved November 10, 2015 .
  3. ↑ DZNE, Dept. for Press, Public Relations: Award for pioneer of Alzheimer's research. In: dzne.de. August 4, 2015, accessed November 10, 2015 .
  4. ^ EMBO announces new members for 2015. In: embo.org. May 20, 2015, accessed November 10, 2015 .
  5. ^ Breakthrough Prize. In: breakthroughprize.org. Retrieved November 10, 2015 .
personal data
SURNAME Hardy, John A.
ALTERNATIVE NAMES Hardy, John; Hardy, John Anthony
BRIEF DESCRIPTION British-American geneticist, molecular biologist and Alzheimer's researcher
DATE OF BIRTH November 9, 1954
PLACE OF BIRTH Nelson (Lancashire)