Michael Molls

Michael Molls

Michael Josef Maria Molls (born December 15, 1944 in Singen ) is a German radiation therapy oncologist and university professor . He initially worked in basic research in radiation biology and then in high-precision radiation therapy and interdisciplinary cancer medicine.

Live and act

After studying and obtaining a license to practice medicine, Molls worked in industrial medicine in Istanbul and Yugoslavia. Years of experimental research followed at the Institute for Pharmacology at the University of Freiburg and at the Institute for Medical Radiation Biology at the University of Essen . He completed his habilitation and was authorized to teach embryology and radiation biology . Molls also worked as an assistant at the radiation clinic at the University of Essen, became a specialist in radiation therapy and senior physician, and received the Venia legendi for clinical radiation oncology . In 1992 he followed the call to the Klinikum rechts der Isar and the Medical Faculty of the Technical University of Munich , where he has since been professor and director of the Clinic for Radiation Therapy and Radiological Oncology. Moll has been retired since March 31, 2014.

From 1999 to 2003 Molls was a member of the board of directors, from 2003 to 2009 of the supervisory board of the Klinikum rechts der Isar. There he devoted himself to the process and result quality in the interdisciplinary treatment of cancer patients. From 2001 to 2003 he was chairman of the Munich Tumor Center at the clinics of both Munich universities.

Molls was co-founder and from 1997 to 1999 President of the German Society for Radiation Oncology (DEGRO). In this function he initiated the introduction of guidelines for the treatment of tumor patients and gave impulses for a reorientation and greater integration of radiobiological and medical-physical research in the field of radiation oncology . From 2004 to 2009 he headed the Academy for Further Education of the German Society for Radiation Oncology (DEGRO). He introduced a curriculum for specialist training (radiation therapy) on the basis of European rules.

As a member of expert commissions of the Science Council , the German Research Foundation (DFG), the Helmholtz Association and ministries , Molls was involved in evaluations and proposals for restructuring and the establishment of new institutions. These include the proton therapy facility being developed at the Dresden University Hospital , the Heidelberg Ion Beam Therapy Center , the National Center for Tumor Diseases (NCT) at the German Cancer Research Center and Heidelberg University Hospital , the former Karlsruhe Research Center of the Helmholtz Association and the Federal Office for Radiation Protection .

research

Molls' scientific work ranges from basic research through translational work to clinical studies . Molls was one of the first in Europe to cultivate the early stages of mouse embryos ( pre-implantation phase, stem cells ) under “in vitro” conditions . On this biological system, he dealt with cell proliferation , mechanisms of cell death , DNA changes, chromosomal damage and embryonic malformations after the application of ionizing radiation ( photons , neutrons ), partly in combination with chemical environmental pollutants or heavy metals ( lead , cadmium ) . From 2008 to 2011 Molls headed the EU (7th Framework Program) funded project Cardiorisk, which experimentally investigated the effects of low radiation doses on the heart and its vessels as part of an international consortium.

Molls is co-spokesman and responsible for the biomedical area of ​​the Munich-Center for Advanced Photonics (MAP) excellence cluster of the German Research Foundation and the major project approved by the Science Council to build a research center "Center for Advanced Laser Applications" (CALA) at both Munich universities. The scientific and organizational dual leadership of MAP (spokesman: F. Krausz / physicist; co-spokesman: M. Molls / medical practitioner) stands for the networking of researchers in physics and bio-medicine .

As part of the MAP cluster, employees of the Molls group are investigating the effects of conventionally and laser- accelerated protons and heavy ions (particles) on normal tissue, on cancer cells and on mouse tumors. These experiments are intended to create the basis for future clinical radiation therapy with laser-generated, pulsed particles.

The preclinical and clinical research of Molls and colleagues is mainly concerned with tumor immunology , tumor hypoxia and the application of innovative imaging methods for biologically adapted high-precision radiation therapy (including "image guidance" and "intensity modulation"). Pioneering work on stereotactic radiation treatment for glioblastomas (brain tumors) and early stages of primary lung cancer as well as publications on the quality of life of patients with breast cancer , patients with prostate cancer and elderly patients originate from the group around Molls .

From 2008 to 2011 Molls was an elected member of the Medical Review Board of the German Research Foundation in the cancer research and medical technology sections. With regard to clinical research and clinical studies , he mainly supported so-called “Investigator Initiated Trials”.

Publications on biological, physical and clinical research by the Molls group

• N. Andratschke, F. Zimmermann, E. Boehm, S. Schill, C. Schoenknecht, R. Thamm, M. Molls, C. Nieder, H. Geinitz: Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer : patterns of failure. In: Radiother Oncol . 101 (2), 2011, pp. 245-249.
• TE Schmid, G. Dollinger, O. Zlobinskaya, D. Michalski, V. Hable, C. Greubel, M. Molls, B. Röper: Relative biological effectiveness of pulsed and continuous 20 MeV protons for micronucleus induction in 3D human reconstructed skin tissue . In: Radiother Oncol. 95 (1), 2010, pp. 66-72.
• JS Vaidya, DJ Joseph, JS Tobias, M. Bulsara, F. Wenz, C. Saunders, M. Alvarado, HL Flyger, S. Massarut, W. Eiermann, M. Keshtgar, J. Dewar, U. Kraus-Tiefenbacher, M. Sütterlin, L. Esserman, HM Holtveg, M. Roncadin, S. Pigorsch, M. Metaxas, M. Falzon, A. Matthews, T. Corica, NR Williams, M. Baum: Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomized, non-inferiority phase 3 trial. In: The Lancet . 376 (9735), 2010, pp. 91-102.
• D. Schilling, M. Gehrmann, C. Steinem, A. De Maio, AG Pockley, M. Abend, M. Molls, G. Multhoff: Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells. In: FASEB J . 23 (8), 2009, pp. 2467-2477.
• H. Geinitz, FB Zimmermann, R. Thamm, A. Schumertl, R. Busch, M. Molls: 3D conformal radiation therapy for prostate cancer in elderly patients. In: Radiother Oncol. 76 (1), 2005, pp. 27-34.
• AL Grosu, WA Weber, M. Franz, S. Stark, M. Piert, R. Thamm, H. Gumprecht, M. Schwaiger, M. Molls, C. Nieder: Reirradiation of recurrent high-grade gliomas using amino acid PET ( SPECT) / CT / MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy. In: Int J Radiat Oncol Biol Phys . 63 (2), 2005, pp. 511-519.
• MN Cornforth, KM Greulich-Bode, BD Loucas, J. Arsuaga, M. Vasquez, RK Sachs, M. Brückner, M. Molls, P. Hahnfeldt, LR Hlatky, DJ Brenner: Chromosomes are predominantly located randomly with respect to each other in interphase human cells. In: J Cell Biol . 159, 2002, pp. 237-244.
• H. Geinitz, FB Zimmermann, P. Stoll, R. Thamm, W. Kaffenberger, K. Ansorg, M. Keller, R. Busch, D. van Beuningen, M. Molls: Fatigue, serum cytokine levels, and blood cell counts during radiotherapy of patients with breast cancer. In: Int J Rad Oncol Biol Phys. 51, 2001, pp. 691-698.
• P. Stadler, A. Becker, HJ Feldmann, G. Hänsgen, J. Dunst, F. Würschmidt, M. Molls: Influence of the hypoxic subvolume on the survival of patients with head and neck cancer. In: Int J Rad Oncol Biol Phys. 44 (4), 1999, pp. 749-754.
• M. Molls, C. Streffer, D. van Beuningen, N. Zamboglou: X-Irradiation in G2-phase of 2-cell mouse embryos in vitro: cleavage, blastulation, cell kinetics and fetal development. In: Radiat Res. 91, 1982, pp. 219-234.

Awards

• Member of the German Academy of Sciences Leopoldina (National Academy of Sciences, since 1998)
• Hanns Langendorff Prize
• Honorary member of the Austrian Society for Radiation Oncology (ÖGRO)
• President of the joint annual congress of the German and Austrian Society for Radiation Oncology and the German Society for Medical Physics (2000)

Web links

• Moll's curriculum vitae at the Technical University of Munich
• Member entry by Michael Molls at the German Academy of Sciences Leopoldina , accessed on April 12, 2015.
• Der Spiegel 26/2002, p. 174 ff. - " Attack from many directions". Interview with Michael Molls
• Entry in the DFG database GEPRIS (funded projects of the DFG)

Individual evidence

1. ↑ Professor at the Technical University of Munich Website of the Technical University of Munich. Retrieved August 16, 2012.
2. ↑ Director of the Clinic for Radiation Therapy and Radiological Oncology Website of the Clinic for Radiation Therapy and Radiological Oncology. Retrieved August 16, 2012.
3. ^ Chairman of the Munich Tumor Center (2001–2003) Website of the Munich Tumor Center. Retrieved December 11, 2012.
4. ↑ Head of the CARDIORISK research project ( Memento of the original from August 15, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. . CARDIORISK website. Retrieved August 16, 2012. 
5. ^ Co-speaker of the DFG Cluster of Excellence Munich Center for Advanced Photonics Website Munich-Center for Advanced Photonics. Retrieved August 16, 2012.
6. ^ Co-initiator of the "Center of Advanced Laser Applications" research center as of July 7, 2010, accessed on August 30, 2012.
7. ^ Project leader SFB 824 - Subproject Project 2 - Validation of Tumor Hypoxia as a Model of Biologically Adapted Radiation Therapy (BART) Website SFB 824, accessed on August 24, 2012.
8. ↑ Member of the DFG Review Board Section 2: "Cancer Research and Regenerative Medicine / Stem Cell Research", term of office 2008–2011 (PDF; 12 kB) website of the DFG. Retrieved August 21, 2012.
9. ↑ Member of the DFG Review Board, Interdisciplinary Medical Technology Section, term of office 2008–2011 (PDF; 17 kB) DFG website. Retrieved August 21, 2012.
10. ↑ Member entry by Michael Molls (with picture) at the German Academy of Natural Scientists Leopoldina , accessed on July 19, 2016.
11. ↑ 2004 honorary member of the Austrian Society for Radiation Oncology website of the ÖGRO. Retrieved February 28, 2016.
12. ↑ Elected President of the 6th German Congress for Radiation Oncology, Radiation Biology and Medical Physics in 2000 in Munich idw on February 10, 1999, accessed on August 24, 2012.