Stanley J. Korsmeyer

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Stanley Joel Korsmeyer (born June 8, 1950 in Beardstown , Illinois , † March 31, 2005 in Boston , Massachusetts ) was an American oncologist and cancer researcher .

Life

Korsmeyer earned a Bachelor in Biology at the University of Illinois at Urbana-Champaign and graduated in medicine at the University of Illinois in Chicago with the MD from. Korsmeyer completed his specialist training at the University of California Hospitals in San Francisco before working as a postdoctoral fellow with Philip Leder and Thomas Waldmann at the National Cancer Institute from 1979 to 1986 . Here he learned, among other things, the techniques for producing recombinant DNA and headed his own research group (senior investigator) .

At Washington University in St. Louis , Korsmeyer was made professor of internal medicine and head of the department of molecular oncology in 1986 .

In 1998, Korsmeyer went to the Dana-Farber Cancer Institute in Boston , where he led the molecular oncology program within the Cancer Immunology and AIDS Division. At the same time, he held professorships in pathology and internal medicine at Harvard Medical School . Since the mid-1980s, Korsmeyer had also conducted research for the Howard Hughes Medical Institute (HHMI).

Korsmeyer died of lung cancer as a non-smoker. He was married and had two sons.

Act

Korsmeyer and co-workers discovered that the protein Bcl-2 develops its oncogenic effect not by increasing cell division , but by inhibiting apoptosis (programmed cell death). He established the doctrine that susceptibility to cell death is a result of the competition between pro-apoptotic (such as Bcl-2 antagonist-of-cell-death and Bax ) and anti-apoptotic members of the Bcl-2 family. With elegant model experiments, he was able to clarify the significance of impaired cell death in cancer , immunodeficiency , autoimmune diseases , infertility and various degenerative diseases.

Awards (selection)

The American Society for Clinical Investigation (ASCI) missed the 10,000 US dollars doped Stanley J. Korsmeyer Award . Korsmeyer was the first recipient of this award in 1998, which was called the ASCI Award until 2005 .

literature

Web links

Individual evidence

  1. ↑ http://www.nasonline.org/member-directory/deceased-members/67729.html
  2. ↑ General Motors Cancer Research Awards Laureates 1979–1998 (PDF, 103 kB) at aacrjournals.org; Retrieved November 24, 2011
  3. ↑ Charles S. Mott Prize (1990-2002) ( Memento from March 14, 2007 in the Internet Archive ) at General Motors (gm.com)
  4. ↑ Book of Members (PDF, 612 kB) of the American Academy of Arts and Sciences (amacad.org); Retrieved November 24, 2011
  5. ^ Horwitz Prize Goes To MIT's Horvitz, Harvard's Korsmeyer at Columbia University (columbia.edu); Retrieved November 24, 2011
  6. ↑ Dr. Stanley J. Korsmeyer at the American Philosophical Society (amphilsoc.org); Retrieved February 4, 2016
  7. ^ Past winners of the Wiley Prize in Biomedical Sciences at wiley.com; Retrieved November 24, 2011
  8. ^ The Stanley J. Korsmeyer Award at the-asci.org; Retrieved November 24, 2011
personal data
SURNAME Korsmeyer, Stanley J.
ALTERNATIVE NAMES Korsmeyer, Stanley; Korsmeyer, Stanley Joel
BRIEF DESCRIPTION American cancer researcher
DATE OF BIRTH June 8, 1950
PLACE OF BIRTH Beardstown , Illinois
DATE OF DEATH March 31, 2005
Place of death Boston , Massachusetts