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{{Short description|Citrus fruit}}
{{Short description|Citrus fruit}}
{{Other uses|Lime (disambiguation)}}
{{Other uses|Lime (disambiguation){{!}}Lime}}
[[File:Lime Blossom.jpg|thumb|The fruit and flower of a [[Persian lime]] (''Citrus'' × ''latifolia'')]]
[[File:Lime Blossom.jpg|thumb|The fruit and flower of a [[Persian lime]] (''Citrus'' × ''latifolia'')]]
[[File:Citrus hystrix dsc07772.jpg|thumb|[[Makrut lime]] fruit]]
[[File:Citrus hystrix dsc07772.jpg|thumb|[[Makrut lime]] fruit]]
[[File:Juliennejern.JPG|thumb|right|Zesting a lime]]
[[File:LimeEssOil.png|right|thumb|180px|Lime essential oil]]


A '''lime''' (from [[French language|French]] ''lime'', from [[Arabic]] ''līma'', from [[Persian language|Persian]] ''līmū'', "lemon")<ref>{{cite web|url=https://www.ahdictionary.com/word/search.html?q=lime|title=The American Heritage Dictionary entry: lime|first=Houghton Mifflin Harcourt Publishing|last=Company|website=www.ahdictionary.com|url-status=live|archive-url=https://web.archive.org/web/20160411173907/https://www.ahdictionary.com/word/search.html?q=lime|archive-date=11 April 2016|df=dmy-all}}</ref> is a [[citrus]] fruit, which is typically round, [[lime (color)|green]] in color (yellowwhen ripe), {{convert|3|–|6|cm|in}} in [[diameter]], and contains [[acid]]ic [[juice vesicles]].<ref name=eb/>
A '''lime''' is a [[citrus]] fruit, which is typically round, [[lime (color)|green]] in color, {{convert|3|–|6|cm|in}} in [[diameter]], and contains [[acid]]ic [[juice vesicles]].<ref name=eb/>


There are several species of citrus trees whose fruits are called limes, including the [[Key lime]] (''Citrus aurantiifolia''), [[Persian lime]], [[kaffir lime|Makrut lime]], and [[Citrus glauca|desert lime]]. Limes are a rich source of [[vitamin C]], are sour, and are often used to accent the flavours of foods and beverages. They are grown year-round.<ref name=Rotter>{{cite web|last1=Rotter|first1=Ben|title=Fruit Data: Yield, Sugar, Acidity, Tannin|url=http://www.brsquared.org/wine/CalcInfo/FruitDat.htm|website=Improved Winemaking|access-date=2014-09-03|url-status=live|archive-url=https://web.archive.org/web/20140608164013/http://www.brsquared.org/wine/CalcInfo/FruitDat.htm|archive-date=8 June 2014|df=dmy-all}}</ref> Plants with fruit called "limes" have diverse genetic origins; limes do not form a [[monophyletic]] group.
There are several species of citrus trees whose fruits are called limes, including the [[Key lime]] (''Citrus aurantiifolia''), [[Persian lime]], [[kaffir lime|Makrut lime]], calamansi limes, finger limes, blood limes, limequats, and [[Citrus glauca|desert lime]]. Limes are a rich source of [[vitamin C]], are sour, and are often used to accent the flavours of foods and beverages. They are grown year-round.<ref name=Rotter>{{cite web|last1=Rotter|first1=Ben|title=Fruit Data: Yield, Sugar, Acidity, Tannin|url=http://www.brsquared.org/wine/CalcInfo/FruitDat.htm|website=Improved Winemaking|access-date=2014-09-03|url-status=live|archive-url=https://web.archive.org/web/20140608164013/http://www.brsquared.org/wine/CalcInfo/FruitDat.htm|archive-date=8 June 2014|df=dmy-all}}</ref> Plants with fruit called "limes" have diverse genetic origins; limes do not form a [[monophyletic]] group. The term ''lime'' originated in other languages (from [[French language|French]] ''lime'', from [[Arabic]] ''līma'', from [[Persian language|Persian]] ''līmū'', "lemon").<ref>{{cite web|url=https://www.ahdictionary.com/word/search.html?q=lime|title=The American Heritage Dictionary entry: lime|first=Houghton Mifflin Harcourt Publishing|last=Company|website=www.ahdictionary.com|url-status=live|archive-url=https://web.archive.org/web/20160411173907/https://www.ahdictionary.com/word/search.html?q=lime|archive-date=11 April 2016|df=dmy-all}}</ref>


==Plants known as "lime"==
==Plants known as "lime"==
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** [[Blood lime]] (red finger lime × (sweet orange × mandarin))
** [[Blood lime]] (red finger lime × (sweet orange × mandarin))
* [[Kaffir lime|Makrut lime]] (''Citrus hystrix''); a [[Papeda (citrus)|papeda]] relative, is one of the three most widely produced limes globally.<ref name="FreshMarketLimes"/>
* [[Kaffir lime|Makrut lime]] (''Citrus hystrix''); a [[Papeda (citrus)|papeda]] relative, is one of the three most widely produced limes globally.<ref name="FreshMarketLimes"/>
* [[Key lime]] (''Citrus'' × ''aurantiifolia''=''[[Citrus micrantha]]'' × ''[[Citrus medica]]''<ref name="auto">{{cite journal |doi = 10.1186/s12863-014-0152-1 |pmid=25544367 |pmc=4302129 |volume=15 |pages=152 |title=Next generation haplotyping to decipher nuclear genomic interspecific admixture in Citrus species: analysis of chromosome 2 |journal=BMC Genetics|year=2014 |last1=Curk |first1=Franck |last2=Ancillo |first2=Gema |last3=Garcia-Lor |first3=Andres |last4=Luro |first4=François |last5=Perrier |first5=Xavier |last6=Jacquemoud-Collet |first6=Jean-Pierre |last7=Navarro |first7=Luis |last8=Ollitrault |first8=Patrick }}</ref><ref>{{cite journal|url=http://journal.ashspublications.org/cgi/content/abstract/135/4/341|title=The Origin of Cultivated Citrus as Inferred from Internal Transcribed Spacer and Chloroplast DNA Sequence and Amplified Fragment Length Polymorphism Fingerprints|journal=Journal of the American Society for Horticultural Science|volume=135|issue=4|pages=341–350|date=July 2010|access-date=24 April 2015|first1=Xiaomeng|last1=Li|first2=Rangjin|last2=Xie|first3=Zhenhua|last3=Lu|first4=Zhiqin|last4=Zhou|url-status=live|archive-url=https://web.archive.org/web/20150424191429/http://journal.ashspublications.org/content/135/4/341.full|archive-date=24 April 2015|doi=10.21273/JASHS.135.4.341|doi-access=free}}</ref><ref>{{cite web|url=http://news.discovery.com/earth/citrus-fruit-gets-paternity-test.htm|title=Citrus Fruit Gets Paternity Test|publisher=Discovery|date=18 January 2011|access-date=24 April 2015|archive-url=https://web.archive.org/web/20130130211206/http://news.discovery.com/earth/citrus-fruit-gets-paternity-test.htm|archive-date=30 January 2013|url-status=live|website=Discovery.com|first=Tim|last=Wall}}</ref>) is also one of the three most widely produced limes globally.<ref name="FreshMarketLimes"/>
* [[Key lime]] (''Citrus'' × ''aurantiifolia''=''[[Citrus micrantha]]'' × ''[[Citrus medica]]''<ref name="auto">{{cite journal |doi = 10.1186/s12863-014-0152-1 |pmid=25544367 |pmc=4302129 |volume=15 |pages=152 |title=Next generation haplotyping to decipher nuclear genomic interspecific admixture in Citrus species: analysis of chromosome 2 |journal=BMC Genetics|year=2014 |last1=Curk |first1=Franck |last2=Ancillo |first2=Gema |last3=Garcia-Lor |first3=Andres |last4=Luro |first4=François |last5=Perrier |first5=Xavier |last6=Jacquemoud-Collet |first6=Jean-Pierre |last7=Navarro |first7=Luis |last8=Ollitrault |first8=Patrick |doi-access=free }}</ref>) is also one of the three most widely produced limes globally.<ref name="FreshMarketLimes"/>
* [[Philippine lime]] (''Citrus'' × ''microcarpa''), a [[kumquat]] × mandarin hybrid<ref>{{cite web |last1=Tacio |first1=Henrylito D. |title=Health benefits of calamansi |url=https://businessmirror.com.ph/2019/04/11/health-benefits-of-calamansi/ |website=BusinessMirror |date=11 April 2019 |access-date=18 October 2020}}</ref>
* [[Philippine lime]] (''Citrus'' × ''microcarpa''), a [[kumquat]] × mandarin hybrid
* [[Persian lime]] (''Citrus'' × ''latifolia'') a key lime × lemon hybrid, is the single most widely produced lime globally, with Mexico being the largest producer.<ref name="FreshMarketLimes">{{cite web|url=http://www.ers.usda.gov/media/1679187/fresh-market-limes-special-article.pdf|title=Fresh-Market Limes|publisher=USDA Economic Research Service|date=26 September 2014|author=Plattner, Kristy|archive-url=https://web.archive.org/web/20150412180430/http://www.ers.usda.gov/media/1679187/fresh-market-limes-special-article.pdf|archive-date=12 April 2015}}</ref>
* [[Persian lime]] (''Citrus'' × ''latifolia'') a key lime × lemon hybrid, is the single most widely produced lime globally, with Mexico being the largest producer.<ref name="FreshMarketLimes">{{cite web|url=http://www.ers.usda.gov/media/1679187/fresh-market-limes-special-article.pdf|title=Fresh-Market Limes|publisher=USDA Economic Research Service|date=26 September 2014|author=Plattner, Kristy|archive-url=https://web.archive.org/web/20150412180430/http://www.ers.usda.gov/media/1679187/fresh-market-limes-special-article.pdf|archive-date=12 April 2015}}</ref>
* [[Rangpur (fruit)|Rangpur lime]] (Mandarin lime, lemandarin,<ref>{{cite web|url=http://www.homecitrusgrowers.co.uk/australiannativecitrus/bloodlime.html|title=Australian Blood Lime|work=homecitrusgrowers.co.uk|url-status=live|archive-url=https://web.archive.org/web/20120831002215/http://www.homecitrusgrowers.co.uk/australiannativecitrus/bloodlime.html|archive-date=31 August 2012|df=dmy-all}}</ref> ''Citrus limonia''), a mandarin orange × citron hybrid
* [[Rangpur (fruit)|Rangpur lime]] (Mandarin lime, lemandarin,<ref>{{cite web|url=http://www.homecitrusgrowers.co.uk/australiannativecitrus/bloodlime.html|title=Australian Blood Lime|work=homecitrusgrowers.co.uk|url-status=live|archive-url=https://web.archive.org/web/20120831002215/http://www.homecitrusgrowers.co.uk/australiannativecitrus/bloodlime.html|archive-date=31 August 2012|df=dmy-all}}</ref> ''Citrus limonia''), a mandarin orange × citron hybrid
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* [[Limequat]] (lime × kumquat)
* [[Limequat]] (lime × kumquat)


Note that the tree species known in Britain as lime trees (''[[Tilia]]'' sp.), called ''linden'' in other dialects of English, are broadleaf temperate plants unrelated to the citrus fruits.
Note that the tree species known in Britain as lime trees (''[[Tilia]]'' sp.), called ''linden'' or ''basswood'' in other dialects of English, are broadleaf temperate plants unrelated to the citrus fruits.


==History==
==History==
{{Main|Citrus#History}}
{{Main|Citrus#History}}
{| class="wikitable" style="float:right; clear:right; width:14em; text-align:center; margin-right:1em;"
{{clear|right}}
|+ Lime (and lemon) production, 2022
{| class="wikitable" style="float: right; margin: 10px;"
|+ Lime (and lemon) production, 2018
|-
|-
! scope="col" | Country
! scope="col" | Country
! scope="col" | Production<br /><small>(millions of tonnes)</small>
! scope="col" | Production<br /><small>(millions <br />of tonnes)</small>
|-
|-
| {{IND}} || 3.1
| {{IND}} ||3.8
|-
|-
| {{MEX}} || 2.5
| {{MEX}} ||3.1
|-
|-
| {{CHN}} || 2.5
| {{CHN}} ||2.6
|-
|-
| {{ARG}} || 2.0
| {{ARG}} ||1.8
|-
|-
| {{BRA}} || 1.5
| {{BRA}} ||1.6
|-
|-
| {{TUR}} || 1.1
| {{TUR}} ||1.3
|-
|-
| '''[[World]]''' || '''19.4'''
| '''World''' ||'''21.5'''
|-
|colspan=2|<small>* includes limes and lemons reported to FAOSTAT</small><br /><small>Source: [[FAOSTAT]] of the United Nations</small><ref name="FAOSTAT2022">{{cite web |title=FAOSTAT |url=https://www.fao.org/faostat/en/#data/QCL/visualize |website=www.fao.org |access-date=24 March 2024}}</ref>
|}
|}

{{nutritional value | name=Nutrition of limes, raw
{{nutritional value | name=Limes, raw
| image=Lime - whole and halved.jpg
| image=Lime - whole and halved.jpg
| caption=Limes, whole and in cross section
| caption=Limes, whole and in cross section
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| folate_ug=8
| folate_ug=8
| source_usda = 1
| source_usda = 1
| note=[https://web.archive.org/web/20161103230456/https://ndb.nal.usda.gov/ndb/search/list?qlookup=09159&format= Full Link to USDA Database entry] }}
| note=[https://fdc.nal.usda.gov/fdc-app.html#/food-details/168155/nutrients Full Link to USDA Database entry] }}


Most species and hybrids of [[citrus]] plants called "limes" have varying origins within tropical [[Southeast Asia]] and [[South Asia]]. They were spread throughout the world via migration and trade. The [[kaffir lime|makrut lime]], in particular, was one of the earliest citrus fruits introduced to other parts of the world by humans. They were spread into [[Micronesia]] and [[Polynesia]] via the [[Austronesian expansion]] (c. 3000–1500 BCE).<ref name="blench">{{cite journal |last1=Blench |first1=R.M. |title=Fruits and arboriculture in the Indo Pacific region |journal=Bulletin of the Indo-Pacific Prehistory Association |date=2005 |volume=24 |pages=31–50 |url=https://www.researchgate.net/publication/255579031}}</ref> They were also later spread into Middle East, and the Mediterranean region via the [[spice trade]] and the [[incense trade route]]s from as early as ~1200 BCE.<ref name="Wu">{{cite journal |vauthors=Wu GA, Terol J, Ibanez V, López-García A, Pérez-Román E, Borredá C, Domingo C, Tadeo FR, Carbonell-Caballero J, Alonso R, Curk F, Du D, Ollitrault P, Roose ML, Dopazo J, Gmitter FG, Rokhsar DS, Talon M |title=Genomics of the origin and evolution of Citrus |journal=Nature |volume=554 |issue=7692 |pages=311–316 |date=February 2018 |pmid=29414943 |doi=10.1038/nature25447 |bibcode=2018Natur.554..311W |doi-access=free }}</ref><ref name="eb">{{cite web | url=https://www.britannica.com/plant/lime | title=Lime | publisher=Encyclopædia Britannica, Inc. | date=2016 | access-date=16 July 2016 | url-status=live | archive-url=https://web.archive.org/web/20160810093643/https://www.britannica.com/plant/lime | archive-date=10 August 2016 | df=dmy-all }}</ref>
Most species and hybrids of [[citrus]] plants called "limes" have varying origins within tropical [[Southeast Asia]] and [[South Asia]]. They were spread throughout the world via migration and trade. The [[kaffir lime|makrut lime]], in particular, was one of the earliest citrus fruits introduced to other parts of the world by humans. They were spread into [[Micronesia]] and [[Polynesia]] via the [[Austronesian expansion]] (c. 3000–1500 BCE).<ref name="blench">{{cite journal |last1=Blench |first1=R.M. |title=Fruits and arboriculture in the Indo Pacific region |journal=Bulletin of the Indo-Pacific Prehistory Association |date=2005 |volume=24 |pages=31–50 |url=https://www.researchgate.net/publication/255579031}}</ref> They were also later spread into Middle East, and the Mediterranean region via the [[spice trade]] and the [[incense trade route]]s from as early as ~1200 BCE.<ref name="Wu">{{cite journal |vauthors=Wu GA, Terol J, Ibanez V, López-García A, Pérez-Román E, Borredá C, Domingo C, Tadeo FR, Carbonell-Caballero J, Alonso R, Curk F, Du D, Ollitrault P, Roose ML, Dopazo J, Gmitter FG, Rokhsar DS, Talon M |title=Genomics of the origin and evolution of Citrus |journal=Nature |volume=554 |issue=7692 |pages=311–316 |date=February 2018 |pmid=29414943 |doi=10.1038/nature25447 |bibcode=2018Natur.554..311W |doi-access=free |hdl=20.500.11939/5741 |hdl-access=free }}</ref><ref name="eb">{{cite web | url=https://www.britannica.com/plant/lime | title=Lime | publisher=Encyclopædia Britannica, Inc. | date=2016 | access-date=16 July 2016 | url-status=live | archive-url=https://web.archive.org/web/20160810093643/https://www.britannica.com/plant/lime | archive-date=10 August 2016 | df=dmy-all }}</ref>


To prevent [[scurvy]] during the 19th century, [[Royal Navy|British sailors]] were issued a daily allowance of citrus, such as [[lemon]], and later switched to lime.<ref>{{Cite journal|pmc=1644345|title=State of knowledge about scurvy|date=3 February 1971|pmid=4552518|volume=65|issue=1|journal=Proc. R. Soc. Med.|pages=39–42 | last1 = Lewis | first1 = HE}}</ref> The use of citrus was initially a closely guarded [[military secret]], as scurvy was a common scourge of various national navies, and the ability to remain at sea for lengthy periods without contracting the disorder was a huge benefit for the military. British sailors thus acquired the nickname "[[Limey]]" because of their use of limes.<ref>{{cite web |url=http://oxforddictionaries.com/definition/Limey |title=Limey |work=Oxford Dictionaries |publisher=[[Oxford University Press]] |access-date=23 April 2013 |url-status=dead |archive-url=https://web.archive.org/web/20120606204837/http://oxforddictionaries.com/definition/Limey |archive-date=6 June 2012 |df=dmy-all }}</ref>
To prevent [[scurvy]] during the 19th century, [[Royal Navy|British sailors]] were issued a daily allowance of citrus, such as [[lemon]], and later switched to lime.<ref>{{Cite journal|pmc=1644345|title=State of knowledge about scurvy|date=3 February 1971|pmid=4552518|volume=65|issue=1|journal=Proc. R. Soc. Med.|pages=39–42 | last1 = Lewis | first1 = HE}}</ref> The use of citrus was initially a closely guarded [[military secret]], as scurvy was a common scourge of various national navies, and the ability to remain at sea for lengthy periods without contracting the disorder was a huge benefit for the military. British sailors thus acquired the nickname "[[Limey]]" because of their use of limes.<ref>{{cite web |url=http://oxforddictionaries.com/definition/Limey |title=Limey |work=Oxford Dictionaries |publisher=[[Oxford University Press]] |access-date=23 April 2013 |url-status=dead |archive-url=https://web.archive.org/web/20120606204837/http://oxforddictionaries.com/definition/Limey |archive-date=6 June 2012 |df=dmy-all }}</ref>


==Production==
==Production==
In 2018, world production of limes (combined with [[Lemon (fruit)|lemons]] for reporting) was 19.4 million [[tonne]]s.<ref name=faostat18/> The top producers &ndash; India, Mexico, China, Argentina, Brazil, and Turkey &ndash; collectively accounted for 65% of global production (table).<ref name="faostat18">{{cite web|url=http://www.fao.org/faostat/en/#data/QC|publisher=Food and Agriculture Organization of the United Nations, Statistics Division (FAOSTAT)|title=World production of lemons and limes in 2018; Crops/Regions/World/Production Quantity from pick lists|date=2019|access-date=19 February 2020}}</ref>
In 2022, world production of limes (combined with [[Lemon (fruit)|lemons]] for reporting) was 21.5 million [[tonne]]s, led by India, Mexico, and China as the major producers (table).

==Uses==


== Uses ==
=== Culinary ===
[[File:Juliennejern.JPG|thumb|right|[[Zest (ingredient)|Zest]]ing a lime]]
Limes have higher contents of sugars and acids than lemons do.<ref name=eb/> Lime juice may be squeezed from fresh limes, or purchased in bottles in both unsweetened and sweetened varieties. Lime juice is used to make [[limeade]], and as an ingredient (typically as [[sour mix]]) in many [[cocktail]]s.
Limes have higher contents of sugars and acids than lemons do.<ref name=eb/> Lime juice may be squeezed from fresh limes, or purchased in bottles in both unsweetened and sweetened varieties. Lime juice is used to make [[limeade]], and as an ingredient (typically as [[sour mix]]) in many [[cocktail]]s.


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Key lime gives the character flavoring to the American dessert known as [[Key lime pie]]. In Australia, desert lime is used for making [[marmalade]].
Key lime gives the character flavoring to the American dessert known as [[Key lime pie]]. In Australia, desert lime is used for making [[marmalade]].


Lime is an ingredient in several [[highball]] [[cocktail]]s, often based on [[gin]], such as [[gin and tonic]], the [[gimlet (cocktail)|gimlet]] and [[the Rickey]]. Freshly squeezed lime juice is also considered a key ingredient in [[margarita]]s, although sometimes [[lemon juice]] is substituted. It is also found in many [[rum]] cocktails such as the [[Daiquiri]], and other tropical drinks.
Lime is an ingredient in several [[highball]] [[cocktail]]s, often based on [[gin]], such as [[gin and tonic]], the [[gimlet (cocktail)|gimlet]] and [[the Rickey]]. Freshly squeezed lime juice is also considered a key ingredient in [[margarita]]s, although sometimes [[lemon juice]] is substituted. It is also found in many [[rum]] cocktails such as the [[daiquiri]], and other tropical drinks.


Lime extracts and lime [[essential oils]] are frequently used in [[perfume]]s, cleaning products, and [[aromatherapy]].
Lime extracts and lime [[essential oils]] are frequently used in [[perfume]]s, cleaning products, and [[aromatherapy]].


[[File:Limes with a Drink.jpg|thumb|Sparkling Water with Limes]]
[[File:LimeEssOil.png|right|thumb|180px|Lime essential oil]]


==Nutrition and phytochemicals==
==Nutrition and phytochemicals==
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Raw limes are 88% water, 10% [[carbohydrate]]s and less than 1% each of [[fat]] and [[protein]] (table). Only [[vitamin C]] content at 35% of the [[Daily Value]] (DV) per 100&nbsp;g serving is significant for nutrition, with other [[nutrients]] present in low DV amounts (table). Lime juice contains slightly less [[citric acid]] than [[lemon]] juice (about 47&nbsp;g/L), nearly twice the citric acid of [[grapefruit]] juice, and about five times the amount of citric acid found in [[Orange (fruit)|orange]] juice.<ref>{{cite journal |vauthors=Penniston KL, Nakada SY, Holmes RP, Assimos DG | title=Quantitative Assessment of Citric Acid in Lemon Juice, Lime Juice, and Commercially-Available Fruit Juice Products | journal=Journal of Endourology | volume=22 | issue=3 | year=2008 | pmid=18290732 | pages = 567–70 | doi = 10.1089/end.2007.0304 | pmc=2637791}}</ref>
Raw limes are 88% water, 10% [[carbohydrate]]s and less than 1% each of [[fat]] and [[protein]] (table). Only [[vitamin C]] content at 35% of the [[Daily Value]] (DV) per 100&nbsp;g serving is significant for nutrition, with other [[nutrients]] present in low DV amounts (table). Lime juice contains slightly less [[citric acid]] than [[lemon]] juice (about 47&nbsp;g/L), nearly twice the citric acid of [[grapefruit]] juice, and about five times the amount of citric acid found in [[Orange (fruit)|orange]] juice.<ref>{{cite journal |vauthors=Penniston KL, Nakada SY, Holmes RP, Assimos DG | title=Quantitative Assessment of Citric Acid in Lemon Juice, Lime Juice, and Commercially-Available Fruit Juice Products | journal=Journal of Endourology | volume=22 | issue=3 | year=2008 | pmid=18290732 | pages = 567–70 | doi = 10.1089/end.2007.0304 | pmc=2637791}}</ref>


Lime pulp and [[peel (fruit)|peel]] contain diverse [[phytochemical]]s, including [[polyphenol]]s and [[terpene]]s,<ref>{{cite journal|journal=J Sci Food Agric|year=2012|volume=92|issue=15|pages=2960–67|doi=10.1002/jsfa.5708|title=Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities|authors=Loizzo MR, Tundis R, Bonesi M, Menichini F, De Luca D, Colica C, Menichini F|pmid=22589172}}</ref> many of which are under [[basic research]] for their potential properties in humans.<ref>{{cite journal|journal=J Agric Food Chem|year=2009|volume=57|issue=22|pages=10933–42|doi=10.1021/jf901718u|title=Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells|authors=Patil JR, Chidambara Murthy KN, Jayaprakasha GK, Chetti MB, Patil BS|pmid=19919125}}</ref>
Lime pulp and [[peel (fruit)|peel]] contain diverse [[phytochemical]]s, including [[polyphenol]]s and [[terpene]]s.<ref>{{cite journal|journal=J Sci Food Agric|year=2012|volume=92|issue=15|pages=2960–67|doi=10.1002/jsfa.5708|title=Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities|vauthors=Loizzo MR, Tundis R, Bonesi M, Menichini F, De Luca D, Colica C, Menichini F |pmid=22589172}}</ref>


==Toxicity==
==Toxicity==


Contact with lime peel or lime juice followed by exposure to [[ultraviolet]] light may lead to [[phytophotodermatitis]],<ref name="Gross et al. 1987">{{cite journal |last1=Gross |first1=T. P. |last2=Ratner |first2=L. |last3=de Rodriguez |first3=O. |last4=Farrel |first4=K. P. |last5=Israel |first5=E. |title=An outbreak of phototoxic dermatitis due to limes |journal=Am J Epidemiol |date=1987 |volume=125 |issue=3 |pages=509–514 |pmid=3812457|doi=10.1093/oxfordjournals.aje.a114557 }}</ref><ref name="Kung et al. 2009">{{cite journal |last1=Kung |first1=A. C. |last2=Stephens |first2=M. B. |last3=Darling |first3=T |title=Phytophotodermatitis: Bulla formation and hyperpigmentation during spring break |journal=Mil. Med. |date=2009 |volume=174 |issue=6 |pages=657–661 |pmid=19585784 |url=https://academic.oup.com/milmed/article-pdf/174/6/657/21615087/milmed-d-01-7208.pdf|doi=10.7205/MILMED-D-01-7208 |doi-access=free }}</ref><ref name="Hankinson et al. 2014">{{cite journal |title=Lime-induced phytophotodermatitis |year=2014 |last1=Hankinson |first1=Andrew |last2=Lloyd |first2=Benjamin |last3=Alweis |first3=Richard |journal=J Community Hosp Intern Med Perspect |volume=4 |issue=4 |pages=25090 |doi=10.3402/jchimp.v4.25090 |pmid=25317269 |pmc=4185147 }}</ref> which is sometimes called margarita [[photodermatitis]]<ref>{{cite journal |url=http://www.the-dermatologist.com/content/what-caused-this-rash-on-this-man%E2%80%99s-wrist-and-hand |first1=Ryan R. |last1=Riahi |first2=Philip R. |last2=Cohen |first3=Floyd W. |last3=Robinson |first4=James M. |last4=Gray |title=What Caused The Rash On This Man's Wrist And Hand? |date=June 2009 |journal=The Dermatologist |volume=11 |issue=6}}</ref><ref>{{cite journal |doi=10.1056/NEJM199303253281220 |title=Margarita Photodermatitis |year=1993 |last1=Abramowitz |first1=Alan I. |last2=Resnik |first2=Kenneth S. |last3=Cohen |first3=Kenneth R. |journal=New England Journal of Medicine |volume=328 |issue=12 |pages=891 |pmid=8441448}}</ref> or lime disease<ref name="Weber et al. 1999">{{cite journal |title=Phytophotodermatitis: The other 'lime' disease |last1=Weber |first1=Ian C |last2=Davis |first2=Charles P |last3=Greeson |first3=David M |year=1999 |journal= [[The Journal of Emergency Medicine]] |volume=17 |issue=2 |pages=235–237 |issn=0736-4679 |pmid=10195477 |doi=10.1016/s0736-4679(98)00159-0}}</ref> (not to be confused with [[Lyme disease]]). Bartenders handling limes and other citrus fruits while preparing cocktails may develop phytophotodermatitis.<ref name="Kanerva2000">{{cite book|author=L. Kanerva|title=Handbook of Occupational Dermatology.|url=https://books.google.com/books?id=ZrclHh9Ep7AC&pg=PA318|year=2000|publisher=Springer|isbn=978-3-540-64046-2|page=318|url-status=live|archive-url=https://web.archive.org/web/20160521235553/https://books.google.com/books?id=ZrclHh9Ep7AC&pg=PA318|archive-date=21 May 2016|df=dmy-all}}</ref>
Contact with lime peel or lime juice followed by exposure to [[ultraviolet]] light may lead to [[phytophotodermatitis]],<ref name="Gross et al. 1987">{{cite journal |last1=Gross |first1=T. P. |last2=Ratner |first2=L. |last3=de Rodriguez |first3=O. |last4=Farrel |first4=K. P. |last5=Israel |first5=E. |title=An outbreak of phototoxic dermatitis due to limes |journal=Am J Epidemiol |date=1987 |volume=125 |issue=3 |pages=509–514 |pmid=3812457|doi=10.1093/oxfordjournals.aje.a114557 }}</ref><ref name="Kung et al. 2009">{{cite journal |last1=Kung |first1=A. C. |last2=Stephens |first2=M. B. |last3=Darling |first3=T |title=Phytophotodermatitis: Bulla formation and hyperpigmentation during spring break |journal=Mil. Med. |date=2009 |volume=174 |issue=6 |pages=657–661 |pmid=19585784 |url=https://academic.oup.com/milmed/article-pdf/174/6/657/21615087/milmed-d-01-7208.pdf|doi=10.7205/MILMED-D-01-7208 |doi-access=free }}</ref><ref name="Hankinson et al. 2014">{{cite journal |title=Lime-induced phytophotodermatitis |year=2014 |last1=Hankinson |first1=Andrew |last2=Lloyd |first2=Benjamin |last3=Alweis |first3=Richard |journal=J Community Hosp Intern Med Perspect |volume=4 |issue=4 |pages=25090 |doi=10.3402/jchimp.v4.25090 |pmid=25317269 |pmc=4185147 }}</ref> which is sometimes called margarita [[photodermatitis]]<ref>{{cite journal |url=http://www.the-dermatologist.com/content/what-caused-this-rash-on-this-man%E2%80%99s-wrist-and-hand |first1=Ryan R. |last1=Riahi |first2=Philip R. |last2=Cohen |first3=Floyd W. |last3=Robinson |first4=James M. |last4=Gray |title=What Caused The Rash On This Man's Wrist And Hand? |date=June 2009 |journal=The Dermatologist |volume=11 |issue=6}}</ref><ref>{{cite journal |doi=10.1056/NEJM199303253281220 |title=Margarita Photodermatitis |year=1993 |last1=Abramowitz |first1=Alan I. |last2=Resnik |first2=Kenneth S. |last3=Cohen |first3=Kenneth R. |journal=New England Journal of Medicine |volume=328 |issue=12 |pages=891 |pmid=8441448|doi-access=free }}</ref> or lime disease<ref name="Weber et al. 1999">{{cite journal |title=Phytophotodermatitis: The other 'lime' disease |last1=Weber |first1=Ian C |last2=Davis |first2=Charles P |last3=Greeson |first3=David M |year=1999 |journal= [[The Journal of Emergency Medicine]] |volume=17 |issue=2 |pages=235–237 |issn=0736-4679 |pmid=10195477 |doi=10.1016/s0736-4679(98)00159-0}}</ref> (not to be confused with [[Lyme disease]]). Bartenders handling limes and other citrus fruits while preparing cocktails may develop phytophotodermatitis.<ref name="Kanerva2000">{{cite book|author=L. Kanerva|title=Handbook of Occupational Dermatology.|url=https://books.google.com/books?id=ZrclHh9Ep7AC&pg=PA318|year=2000|publisher=Springer|isbn=978-3-540-64046-2|page=318|url-status=live|archive-url=https://web.archive.org/web/20160521235553/https://books.google.com/books?id=ZrclHh9Ep7AC&pg=PA318|archive-date=21 May 2016|df=dmy-all}}</ref>


A class of organic chemical compounds called [[furanocoumarin]]s are reported to cause phytophotodermatitis in humans.<ref name="McGovern and Barkley 2000">{{cite journal |journal=The Electronic Textbook of Dermatology |url=http://telemedicine.org/botanica/bot1.htm |title=Botanical Dermatology |last1=McGovern |first1=Thomas W. |last2=Barkley |first2=Theodore M. |at=Section&nbsp;[http://telemedicine.org/botanica/bot5.htm Phytophotodermatitis] |publisher=Internet Dermatology Society |date=2000 |volume=37 |issue=5 |doi=10.1046/j.1365-4362.1998.00385.x |pmid=9620476 |s2cid=221810453 |access-date=November 29, 2018}}</ref> Limes contain numerous furanocoumarin compounds, including [[limettin]] (also called [[citropten]]), [[bergapten]], [[isopimpinellin]], xanthotoxin (also called [[methoxsalen]]), and [[psoralen]].<ref name="Nigg et al. 1993">{{cite journal |journal=Food Chem Toxicol |year=1993 |volume=31 |issue=5 |pages=331–35 |title=Phototoxic coumarins in limes |last1=Nigg |first1=H. N. |last2=Nordby |first2=H. E. |last3=Beier |first3=R. C. |last4=Dillman |first4=A. |last5=Macias |first5=C. |last6=Hansen |first6=R. C. |pmid=8505017 |doi=10.1016/0278-6915(93)90187-4|url=https://eurekamag.com/pdf/002/002671183.pdf}}</ref><ref name="Wagner et al. 2002">{{cite journal |last1=Wagner |first1=A. M. |last2=Wu |first2=J. J. |last3=Hansen |first3=R. C. |last4=Nigg |first4=H. N. |last5=Beiere |first5=R. C. |title=Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes |journal=Am J Contact Dermat |date=2002 |volume=13 |issue=1 |pages=10–14 |doi=10.1053/ajcd.2002.29948 |pmid=11887098 |issn=0891-5849}}</ref> Bergapten appears to be the primary furanocoumarin compound responsible for lime-induced phytophotodermatitis.<ref name="Nigg et al. 1993" /><ref name="Wagner et al. 2002" />
A class of organic chemical compounds called [[furanocoumarin]]s are reported to cause phytophotodermatitis in humans.<ref name="McGovern and Barkley 2000">{{cite journal |journal=The Electronic Textbook of Dermatology |url=http://telemedicine.org/botanica/bot1.htm |title=Botanical Dermatology |last1=McGovern |first1=Thomas W. |last2=Barkley |first2=Theodore M. |at=Section&nbsp;[http://telemedicine.org/botanica/bot5.htm Phytophotodermatitis] |publisher=Internet Dermatology Society |date=2000 |volume=37 |issue=5 |doi=10.1046/j.1365-4362.1998.00385.x |pmid=9620476 |s2cid=221810453 |access-date=November 29, 2018}}</ref> Limes contain numerous furanocoumarin compounds, including [[limettin]] (also called [[citropten]]), [[bergapten]], [[isopimpinellin]], xanthotoxin (also called [[methoxsalen]]), and [[psoralen]].<ref name="Nigg et al. 1993">{{cite journal |journal=Food Chem Toxicol |year=1993 |volume=31 |issue=5 |pages=331–35 |title=Phototoxic coumarins in limes |last1=Nigg |first1=H. N. |last2=Nordby |first2=H. E. |last3=Beier |first3=R. C. |last4=Dillman |first4=A. |last5=Macias |first5=C. |last6=Hansen |first6=R. C. |pmid=8505017 |doi=10.1016/0278-6915(93)90187-4|url=https://eurekamag.com/pdf/002/002671183.pdf}}</ref><ref name="Wagner et al. 2002">{{cite journal |last1=Wagner |first1=A. M. |last2=Wu |first2=J. J. |last3=Hansen |first3=R. C. |last4=Nigg |first4=H. N. |last5=Beiere |first5=R. C. |title=Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes |journal=Am J Contact Dermat |date=2002 |volume=13 |issue=1 |pages=10–14 |doi=10.1053/ajcd.2002.29948 |pmid=11887098 |issn=0891-5849}}</ref> Bergapten appears to be the primary furanocoumarin compound responsible for lime-induced phytophotodermatitis.<ref name="Nigg et al. 1993" /><ref name="Wagner et al. 2002" />


Lime [[peel (fruit)|peel]] contains higher concentrations of furanocoumarins than lime pulp (by one or two orders of magnitude),<ref name="Nigg et al. 1993" /><ref name="Wagner et al. 2002" /> and so lime peels are considerably more [[phototoxicity|phototoxic]] than lime pulp. [[Persian lime]]s appear to be more phototoxic than [[Key lime]]s.<ref name="Nigg et al. 1993" />
Lime [[peel (fruit)|peel]] contains higher concentrations of furanocoumarins than lime pulp (by one or two orders of magnitude),<ref name="Nigg et al. 1993" /><ref name="Wagner et al. 2002" /> and so lime peels are considerably more [[phototoxicity|phototoxic]] than lime pulp.


==See also==
==See also==

Latest revision as of 10:01, 28 March 2024

The fruit and flower of a Persian lime (Citrus × latifolia)
Makrut lime fruit

A lime is a citrus fruit, which is typically round, green in color, 3–6 centimetres (1.2–2.4 in) in diameter, and contains acidic juice vesicles.[1]

There are several species of citrus trees whose fruits are called limes, including the Key lime (Citrus aurantiifolia), Persian lime, Makrut lime, calamansi limes, finger limes, blood limes, limequats, and desert lime. Limes are a rich source of vitamin C, are sour, and are often used to accent the flavours of foods and beverages. They are grown year-round.[2] Plants with fruit called "limes" have diverse genetic origins; limes do not form a monophyletic group. The term lime originated in other languages (from French lime, from Arabic līma, from Persian līmū, "lemon").[3]

Plants known as "lime"[edit]

The difficulty in identifying exactly which species of fruit are called lime in different parts of the English-speaking world (and the same problem applies to synonyms in other European languages) is increased by the botanical complexity of the citrus genus itself, to which the majority of limes belong. Species of this genus hybridise readily, and it is only recently that genetic studies have started to shed light on the structure of the genus. The majority of cultivated species are in reality hybrids, produced from the citron (Citrus medica), the mandarin orange (Citrus reticulata), the pomelo (Citrus maxima) and in particular with many lime varieties, the micrantha (Citrus hystrix var. micrantha).

Note that the tree species known in Britain as lime trees (Tilia sp.), called linden or basswood in other dialects of English, are broadleaf temperate plants unrelated to the citrus fruits.

History[edit]

Lime (and lemon) production, 2022
Country Production
(millions
of tonnes)
 India 3.8
 Mexico 3.1
 China 2.6
 Argentina 1.8
 Brazil 1.6
 Turkey 1.3
World 21.5
* includes limes and lemons reported to FAOSTAT
Source: FAOSTAT of the United Nations[7]
Limes, raw
Limes, whole and in cross section
Nutritional value per 100 g (3.5 oz)
Energy126 kJ (30 kcal)
10.5 g
Sugars1.7 g
Dietary fiber2.8 g
0.2 g
0.7 g
VitaminsQuantity
%DV
Thiamine (B1)
3%
0.03 mg
Riboflavin (B2)
2%
0.02 mg
Niacin (B3)
1%
0.2 mg
Pantothenic acid (B5)
4%
0.217 mg
Vitamin B6
3%
0.046 mg
Folate (B9)
2%
8 μg
Vitamin C
32%
29.1 mg
MineralsQuantity
%DV
Calcium
3%
33 mg
Iron
3%
0.6 mg
Magnesium
1%
6 mg
Phosphorus
1%
18 mg
Potassium
3%
102 mg
Sodium
0%
2 mg
Other constituentsQuantity
Water88.3 g

Percentages estimated using US recommendations for adults,[8] except for potassium, which is estimated based on expert recommendation from the National Academies.[9]

Most species and hybrids of citrus plants called "limes" have varying origins within tropical Southeast Asia and South Asia. They were spread throughout the world via migration and trade. The makrut lime, in particular, was one of the earliest citrus fruits introduced to other parts of the world by humans. They were spread into Micronesia and Polynesia via the Austronesian expansion (c. 3000–1500 BCE).[10] They were also later spread into Middle East, and the Mediterranean region via the spice trade and the incense trade routes from as early as ~1200 BCE.[11][1]

To prevent scurvy during the 19th century, British sailors were issued a daily allowance of citrus, such as lemon, and later switched to lime.[12] The use of citrus was initially a closely guarded military secret, as scurvy was a common scourge of various national navies, and the ability to remain at sea for lengthy periods without contracting the disorder was a huge benefit for the military. British sailors thus acquired the nickname "Limey" because of their use of limes.[13]

Production[edit]

In 2022, world production of limes (combined with lemons for reporting) was 21.5 million tonnes, led by India, Mexico, and China as the major producers (table).

Uses[edit]

Culinary[edit]

Zesting a lime

Limes have higher contents of sugars and acids than lemons do.[1] Lime juice may be squeezed from fresh limes, or purchased in bottles in both unsweetened and sweetened varieties. Lime juice is used to make limeade, and as an ingredient (typically as sour mix) in many cocktails.

Lime pickles are an integral part of Indian cuisine, especially in South India. In Kerala, the Onam Sadhya usually includes either lemon pickle or lime pickle. Other Indian preparations of limes include sweetened lime pickle, salted pickle, and lime chutney.

In cooking, lime is valued both for the acidity of its juice and the floral aroma of its zest. It is a common ingredient in authentic Mexican, Vietnamese and Thai dishes. Lime soup is a traditional dish from the Mexican state of Yucatan. It is also used for its pickling properties in ceviche. Some guacamole recipes call for lime juice.

The use of dried limes (called black lime or limoo) as a flavouring is typical of Persian cuisine, Iraqi cuisine, as well as in Eastern Arabian cuisine baharat (a spice mixture that is also called kabsa or kebsa).

Key lime gives the character flavoring to the American dessert known as Key lime pie. In Australia, desert lime is used for making marmalade.

Lime is an ingredient in several highball cocktails, often based on gin, such as gin and tonic, the gimlet and the Rickey. Freshly squeezed lime juice is also considered a key ingredient in margaritas, although sometimes lemon juice is substituted. It is also found in many rum cocktails such as the daiquiri, and other tropical drinks.

Lime extracts and lime essential oils are frequently used in perfumes, cleaning products, and aromatherapy.

Lime essential oil

Nutrition and phytochemicals[edit]

Raw limes are 88% water, 10% carbohydrates and less than 1% each of fat and protein (table). Only vitamin C content at 35% of the Daily Value (DV) per 100 g serving is significant for nutrition, with other nutrients present in low DV amounts (table). Lime juice contains slightly less citric acid than lemon juice (about 47 g/L), nearly twice the citric acid of grapefruit juice, and about five times the amount of citric acid found in orange juice.[14]

Lime pulp and peel contain diverse phytochemicals, including polyphenols and terpenes.[15]

Toxicity[edit]

Contact with lime peel or lime juice followed by exposure to ultraviolet light may lead to phytophotodermatitis,[16][17][18] which is sometimes called margarita photodermatitis[19][20] or lime disease[21] (not to be confused with Lyme disease). Bartenders handling limes and other citrus fruits while preparing cocktails may develop phytophotodermatitis.[22]

A class of organic chemical compounds called furanocoumarins are reported to cause phytophotodermatitis in humans.[23] Limes contain numerous furanocoumarin compounds, including limettin (also called citropten), bergapten, isopimpinellin, xanthotoxin (also called methoxsalen), and psoralen.[24][25] Bergapten appears to be the primary furanocoumarin compound responsible for lime-induced phytophotodermatitis.[24][25]

Lime peel contains higher concentrations of furanocoumarins than lime pulp (by one or two orders of magnitude),[24][25] and so lime peels are considerably more phototoxic than lime pulp.

See also[edit]

References[edit]

  1. ^ a b c "Lime". Encyclopædia Britannica, Inc. 2016. Archived from the original on 10 August 2016. Retrieved 16 July 2016.
  2. ^ Rotter, Ben. "Fruit Data: Yield, Sugar, Acidity, Tannin". Improved Winemaking. Archived from the original on 8 June 2014. Retrieved 3 September 2014.
  3. ^ Company, Houghton Mifflin Harcourt Publishing. "The American Heritage Dictionary entry: lime". www.ahdictionary.com. Archived from the original on 11 April 2016.
  4. ^ a b c Plattner, Kristy (26 September 2014). "Fresh-Market Limes" (PDF). USDA Economic Research Service. Archived from the original (PDF) on 12 April 2015.
  5. ^ Curk, Franck; Ancillo, Gema; Garcia-Lor, Andres; Luro, François; Perrier, Xavier; Jacquemoud-Collet, Jean-Pierre; Navarro, Luis; Ollitrault, Patrick (2014). "Next generation haplotyping to decipher nuclear genomic interspecific admixture in Citrus species: analysis of chromosome 2". BMC Genetics. 15: 152. doi:10.1186/s12863-014-0152-1. PMC 4302129. PMID 25544367.
  6. ^ "Australian Blood Lime". homecitrusgrowers.co.uk. Archived from the original on 31 August 2012.
  7. ^ "FAOSTAT". www.fao.org. Retrieved 24 March 2024.
  8. ^ United States Food and Drug Administration (2024). "Daily Value on the Nutrition and Supplement Facts Labels". Retrieved 28 March 2024.
  9. ^ National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Food and Nutrition Board; Committee to Review the Dietary Reference Intakes for Sodium and Potassium (2019). Oria, Maria; Harrison, Meghan; Stallings, Virginia A. (eds.). Dietary Reference Intakes for Sodium and Potassium. The National Academies Collection: Reports funded by National Institutes of Health. Washington, DC: National Academies Press (US). ISBN 978-0-309-48834-1. PMID 30844154.
  10. ^ Blench, R.M. (2005). "Fruits and arboriculture in the Indo Pacific region". Bulletin of the Indo-Pacific Prehistory Association. 24: 31–50.
  11. ^ Wu GA, Terol J, Ibanez V, López-García A, Pérez-Román E, Borredá C, Domingo C, Tadeo FR, Carbonell-Caballero J, Alonso R, Curk F, Du D, Ollitrault P, Roose ML, Dopazo J, Gmitter FG, Rokhsar DS, Talon M (February 2018). "Genomics of the origin and evolution of Citrus". Nature. 554 (7692): 311–316. Bibcode:2018Natur.554..311W. doi:10.1038/nature25447. hdl:20.500.11939/5741. PMID 29414943.
  12. ^ Lewis, HE (3 February 1971). "State of knowledge about scurvy". Proc. R. Soc. Med. 65 (1): 39–42. PMC 1644345. PMID 4552518.
  13. ^ "Limey". Oxford Dictionaries. Oxford University Press. Archived from the original on 6 June 2012. Retrieved 23 April 2013.
  14. ^ Penniston KL, Nakada SY, Holmes RP, Assimos DG (2008). "Quantitative Assessment of Citric Acid in Lemon Juice, Lime Juice, and Commercially-Available Fruit Juice Products". Journal of Endourology. 22 (3): 567–70. doi:10.1089/end.2007.0304. PMC 2637791. PMID 18290732.
  15. ^ Loizzo MR, Tundis R, Bonesi M, Menichini F, De Luca D, Colica C, Menichini F (2012). "Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities". J Sci Food Agric. 92 (15): 2960–67. doi:10.1002/jsfa.5708. PMID 22589172.
  16. ^ Gross, T. P.; Ratner, L.; de Rodriguez, O.; Farrel, K. P.; Israel, E. (1987). "An outbreak of phototoxic dermatitis due to limes". Am J Epidemiol. 125 (3): 509–514. doi:10.1093/oxfordjournals.aje.a114557. PMID 3812457.
  17. ^ Kung, A. C.; Stephens, M. B.; Darling, T (2009). "Phytophotodermatitis: Bulla formation and hyperpigmentation during spring break" (PDF). Mil. Med. 174 (6): 657–661. doi:10.7205/MILMED-D-01-7208. PMID 19585784.
  18. ^ Hankinson, Andrew; Lloyd, Benjamin; Alweis, Richard (2014). "Lime-induced phytophotodermatitis". J Community Hosp Intern Med Perspect. 4 (4): 25090. doi:10.3402/jchimp.v4.25090. PMC 4185147. PMID 25317269.
  19. ^ Riahi, Ryan R.; Cohen, Philip R.; Robinson, Floyd W.; Gray, James M. (June 2009). "What Caused The Rash On This Man's Wrist And Hand?". The Dermatologist. 11 (6).
  20. ^ Abramowitz, Alan I.; Resnik, Kenneth S.; Cohen, Kenneth R. (1993). "Margarita Photodermatitis". New England Journal of Medicine. 328 (12): 891. doi:10.1056/NEJM199303253281220. PMID 8441448.
  21. ^ Weber, Ian C; Davis, Charles P; Greeson, David M (1999). "Phytophotodermatitis: The other 'lime' disease". The Journal of Emergency Medicine. 17 (2): 235–237. doi:10.1016/s0736-4679(98)00159-0. ISSN 0736-4679. PMID 10195477.
  22. ^ L. Kanerva (2000). Handbook of Occupational Dermatology. Springer. p. 318. ISBN 978-3-540-64046-2. Archived from the original on 21 May 2016.
  23. ^ McGovern, Thomas W.; Barkley, Theodore M. (2000). "Botanical Dermatology". The Electronic Textbook of Dermatology. 37 (5). Internet Dermatology Society. Section Phytophotodermatitis. doi:10.1046/j.1365-4362.1998.00385.x. PMID 9620476. S2CID 221810453. Retrieved 29 November 2018.
  24. ^ a b c Nigg, H. N.; Nordby, H. E.; Beier, R. C.; Dillman, A.; Macias, C.; Hansen, R. C. (1993). "Phototoxic coumarins in limes" (PDF). Food Chem Toxicol. 31 (5): 331–35. doi:10.1016/0278-6915(93)90187-4. PMID 8505017.
  25. ^ a b c Wagner, A. M.; Wu, J. J.; Hansen, R. C.; Nigg, H. N.; Beiere, R. C. (2002). "Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes". Am J Contact Dermat. 13 (1): 10–14. doi:10.1053/ajcd.2002.29948. ISSN 0891-5849. PMID 11887098.

External links[edit]