Susan Lindquist

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Susan Lindquist

Susan Lee Lindquist (born June 5, 1949 in Chicago - † October 27, 2016 in Boston ) was an American biologist and professor of molecular biology at the Massachusetts Institute of Technology . She was a member and former director of the Whitehead Institute for Biomedical Research .

Life

Susan Lindquist studied microbiology at the University of Illinois and graduated in 1971 with a Bachelor of Arts . She received her PhD in biology from Harvard University in 1976 . She later held the Albert D. Lasker Chair of Medicine in the Department of Molecular Genetics and Cell Biology at the University of Chicago . Most recently she was Professor of Biology at MIT . From 2001 to 2004 she was also director of the Whitehead Institute for Biomedical Research there . From 1988 to 2001 she also conducted research for the Howard Hughes Medical Institute .

Lindquist was married to Edward Buckbee and had two grown daughters. She died of cancer .

Lindquist's research

Lindquist's research focused on protein folding . She was able to show that altered protein folding controls numerous biological processes and has a decisive influence on the question of whether a cell can survive extreme stress ( e.g. heat shock , exposure to cell toxins ). Lindquist isolated mRNA derived from chromosomal structures that are remodeled by heat shock. She was able to make important contributions to the elucidation of the function and the autoregulation of the heat shock protein Hsp70 on the level of transcription and translation .

Further processes that are influenced by the rearrangement and refolding of proteins are the activation or inactivation of functional proteins, the effects of mutations and the formation of memory at the synapses of nerve cells . Disturbances of protein folding are - partly proven, partly suspected - causally involved in the development of diseases such as Alzheimer's disease , Huntington 's disease and Parkinson's disease . Misfolded proteins that can transfer their disturbance to other proteins are called prions and are the substrate of Creutzfeldt-Jakob disease and bovine spongiform encephalopathy (BSE).

Lindquist and co-workers were able to show that certain “genetic” properties - favorable as well as harmful - are transmitted through self- perpetuating changes in protein folding, thus broadening the view of further possible mechanisms of inheritance.

Awards and memberships (selection)

Fonts

  • with Bruno Maresca: Heat shock. Springer, Berlin et al. 1991, ISBN 3-540-54111-X .
  • with C. Dai, L. Whitesell and AB Rogers: Heat-shock factor 1 is a powerful multifaceted modifier of carcinogenesis. In: Cell. v. 130, 2007, pp. 1005-1018.
  • with AA Cooper, AD Gitler, A. Cashikar, CM Haynes, KJ Hill, B. Bhullar, K. Liu, K. Xu, KE Strathearn, F. Liu, S. Cao, KA Caldwell, GA Caldwell, G. Marsischky, RD Kolodner, J. LaBaer, ​​JC. Rochet and NM Bonini: alpha-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models. In: Science. v. 313, 2006, pp. 324-328.
  • with LE Cowen: Hsp90 potentiates the rapid evolution of new traits: Drug resistance in diverse fungi. In: Science. v. 309, 2005, pp. 2185-2189.
  • with R. Krishnan: Structural insights into a yeast prion illuminate nucleation and strain diversity. In: Nature. v. 435, 2005, pp. 765-772.
  • with K. Si and ER Kandel: A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties. In: Cell. v. 115, 2003, pp. 879-891.
  • with C. Queitsch and TA Sangster: Hsp90 as a capacitor of phenotypic variation. In: Nature. v. 417, 2002, pp. 618-624.
  • with TR Serio, AG Cashikar, AS Kowal, GJ Sawicki, JJ Moslehi, L. Serpell and MF Arnsdorf: Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant. In: Science. v. 289, 2000, pp. 1317-1321.
  • with MM Patino, JJ Liu and JR Glover: Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. In: Science. v. 273, 1996, pp. 622-626.
  • Regulation of protein synthesis during heat shock. In: Nature. v. 293, 1981, pp. 311-314.

literature

Web links

Commons : Susan Lindquist  - Collection of Images, Videos and Audio Files

Individual evidence

  1. ↑ Log In - New York Times. In: nytimes.com. October 28, 2016, accessed October 31, 2016 .
  2. ↑ 2003 Dickson Prize Winner Susan L. Lindquist, PhD at dicksonprize.pitt.edu; Retrieved June 22, 2011.
  3. ^ Member History: Susan L. Lindquist. American Philosophical Society, accessed November 22, 2018 .
  4. ↑ Member entry by Prof. Dr. Susan Lindquist (with picture) at the German Academy of Sciences Leopoldina , accessed on July 17, 2016.
  5. ^ Nancy Hopkins: The 2008 Genetics Society of America Medal. Susan Lindquist . In: Genetics . tape 178 , no. 3 , March 2008, p. 1125-1128 , doi : 10.1534 / genetics.104.017834 , PMID 18385104 , PMC 2278094 (free full text).
  6. ↑ Susan Lee Lindquist at nsf.gov; Retrieved June 22, 2011.
  7. ↑ Professor Susan Lindquist from the Whitehead Institute Receives Max Delbrück Medal in Berlin ( Memento of the original from July 17, 2011 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. at mdc-berlin.de; Retrieved June 22, 2011. @1@ 2Template: Webachiv / IABot / www.mdc-berlin.de
personal data
SURNAME Lindquist, Susan
ALTERNATIVE NAMES Lindquist, Susan L .; Lindquist, Susan Lee (full name)
BRIEF DESCRIPTION American molecular biologist and university professor
DATE OF BIRTH June 5, 1949
PLACE OF BIRTH Chicago
DATE OF DEATH October 27, 2016
Place of death Boston