Spadea turned pro in 1993. In his second year on the ATP Tour , he finished the season in the top 100 of the tennis world rankings as the youngest American. He was initially more successful in doubles than in singles, so he celebrated his first title in the doubles competition in Buenos Aires in 1995 . Also in 2005 he finished as the youngest American in the top 100. In 1997 two more double successes followed in Orlando and Tashkent .
In the following years he gained dubious fame through a negative streak of 21 defeats in a row, which he was only able to break in the 2000 season at Wimbledon against Greg Rusedski . As a result of this unsuccessfulness, he was more active in the 2001 season at the ATP Challenger Series , where he won the tournament in Houston and also reached three other finals. In 2002 he won another Challenger tournament in Miami .
In the 2003 season he fought his way back up in the world rankings thanks to good results, especially in Masters tournaments . So he reached the semi-finals of the Indian Wells Masters and the Masters tournament in Monte Carlo . 2004 was his most successful season, which he was able to crown with his only single title in Scottsdale . He also received $ 704,105 in prize money, which made 2004 his most lucrative year.
He reached his best mark in the world rankings in singles on February 28, 2005 with 18th place, in doubles with 90th place on June 12, 2006.
Vincent Spadea ended his professional career in 2010.