Samuel Danishefsky
Samuel Joseph Danishefsky (born March 10, 1936 in Bayonne , New Jersey ) is an American chemist.
life and work
Samuel Danishefsky received his bachelor's degree in chemistry from Yeshiva University in 1956 . In 1962, he was with Peter Yates with the theme rearrangement of diazo derivative of the bicyclo (2.2.1) heptane system at Harvard University as a doctor of chemistry doctorate . From 1961 to 1963 he was a post-doctoral student with Gilbert Stork at Columbia University . He then moved to the University of Pittsburgh , where he worked his way up from assistant professor (1964-68) to associate professor (1968-71) and professor (1971-79) to university professor (1978-79). From 1979 to 1993 he was a professor at Yale University , where he was also dean of the chemistry faculty from 1981 to 1987, Eugene Higgins professor from 1983 to 1989 and Sterling Professor from 1989 to 1993 . Since 1991 Danishefsky has been director of the Bioorganic Chemistry Laboratory at Memorial Sloan-Kettering Cancer Center , New York. Since 1993 he has also held the Eugene W. Kettering Chair at the Sloan-Kettering Institute for Cancer Research and a chemistry professorship at Columbia University.
Danishefsky works on the development of new synthetic methods in organic chemistry . He is pursuing two directions in particular: First, the synthesis of small, clinically useful molecules that are to be used, for example, in the treatment of cancer , Alzheimer's , Huntington's and Parkinson's . He starts with natural, biologically active molecules, removes side branches and manipulates functional groups in order to obtain substances with higher effectiveness and improved pharmacological properties. The second thrust of his research is the synthesis of carbohydrate-based tumor antigens . To do this, he creates complex oligosaccharides , glycoconjugates and glycopeptides .
Awards (selection)
- 1980 Ernest Guenther Award in Chemistry of Natural Products (American Chemical Society)
- 1986 Aldrich Award for Creative Work in Synthetic Organic (American Chemical Society)
- 1987 Honorary Doctorate , Yeshiva University
- 1988 Edgar Fahs Smith Award (American Chemical Society)
- 1991 Graduate Training Awardee (Pfizer)
- 1994 Cliff Hamilton Award (University of Nebraska)
- 1996 Tetrahedron Prize (Elsevier)
- 1996 Wolf Prize (together with Gilbert Stork)
- 1997 Claude S. Hudson Award in Carbohydrate Chemistry (American Chemical Society)
- 1997 Allan Day Medal (University of Pennsylvania)
- 1998 Arthur C. Cope Award (American Chemical Society)
- 1999 Nagoya Gold Medal
- 1999 Nichols Medal (American Chemical Society)
- 2000 HC Brown Medal (American Chemical Society)
- 2001 FA Cotton Medal for Excellence in Chemical Research (American Chemical Society)
- 2002 Award for Creativity in Organic Chemistry (Pfizer)
- 2006 NAS Award in Chemical Sciences (National Academy of Sciences)
- 2006 Benjamin Franklin Medal in Chemistry (Franklin Institute)
- 2006 Bristol-Myers Squibb Distinguished Achievement Award in Organic Synthesis
- Award for Creative Work in Chemical Synthesis (American Chemical Society)
- 2013 Ralph F. Hirschmann Award in Peptide Chemistry (American Chemical Society)
- 2018 Sir Derek H. Barton Gold Medal (Royal Society of Chemistry)
Memberships
- 1980 Japanese Society for the Promotion of Science
- 1984 American Academy of Arts and Sciences
- 1985 American Association for the Advancement of Science
- 1986 National Academy of Sciences
- 1987 Connecticut Academy of Sciences
- American Chemical Society
- Swiss Chemical Society
- Japanese Chemical Society
See also
- Danishefsky diene : a special diene especially used for Diels-Alder reactions .
literature
- Who's Who in America. 2007, p. 1017, ISBN 0-8379-7006-7
Web links
- Literature by and about Samuel Danishefsky in the catalog of the German National Library
- Research Summary on columbia.edu (English)
- Short biography on tu-berlin.de
- Chemist Samuel Danishefsky Wins Trio of Awards on mskcc.org
Individual evidence
- ^ Biographical data, publications and academic family tree of Samuel J. Danishefsky at academictree.org, accessed on January 29, 2018.
personal data | |
---|---|
SURNAME | Danishefsky, Samuel |
ALTERNATIVE NAMES | Danishefsky, Samuel J .; Danishefsky, Samuel Joseph (full name) |
BRIEF DESCRIPTION | American chemist |
DATE OF BIRTH | March 10, 1936 |
PLACE OF BIRTH | Bayonne , New Jersey , USA |