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Neuropeptides are peptides found in nerve tissue .


They serve as messenger substances and are released either endocrinically as neurosecretory peptide hormones or paracrinely as cotransmitter . As hormones, they reach the target cells via the bloodstream. As cotransmitters, they act as neuromodulators by modulating, i.e. supporting or inhibiting, the action of the neurotransmitters . To date, over 100 different neuropeptides are known. Well-known representatives are z. B. the endorphins as the body's own opioids .

In contrast to low molecular weight messenger substances, the synthesis and the transport are rather slow and sluggish. The neuropeptides are synthesized on the ribosomes in the perikaryon and not - as is the case with low-molecular messenger substances - in the axon . In addition, cotransmitters do not bind directly to ion channels and therefore do not change the tension of the postsynaptic membrane, but act via receptors on cell functions and on the cell structure of the postsynaptic target cell.

Neurosecretory peptide hormones




The following list shows a selection of neurotransmitters and some of the peptide cotransmitters that occur with them.

  • Cotransmitter from GABA
  • More cotransmitters

Web links

Individual evidence

  1. Medical Dictionary, keyword 'neuropeptides' . Retrieved October 4, 2013.