Franz-Ulrich Hartl

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Franz-Ulrich Hartl (born March 10, 1957 in Essen ) is a German cell biologist .

life and work

Hartl studied medicine at the University of Heidelberg , where he passed his medical state examination in 1982 . In 1985 he was with Hans Schimassek at the Institute of Biochemistry with summa cum laude to the Dr. med. PhD . In 1985 and 1986 he worked as a post-doctoral student with Walter Neupert at the Institute for Physiological Chemistry at the University of Munich . There he was working group leader from 1987 to 1989. Another postdoctoral stay took him to William Wickner at the University of California, Los Angeles . In 1990 he completed his habilitation - again in Munich - as Dr. med. habil. and became Academic Councilor there . The following year, he was appointed Associate Professor of Cell Biology and Genetics at Cornell University . At the same time he worked at the Sloan Kettering Institute . In 1993 he became a full professor and in 1995 William E. Snee professor. He was also an Associate Investigator at the Howard Hughes Medical Institute from 1994 . He returned to Germany in 1997 as director of the cellular biochemistry department at the Max Planck Institute for Biochemistry Martinsried. In the same year he received an honorary professorship at the University of Munich. From 2001 to 2003 he was Vice President and from 2003 to 2005 President of the Society for Biochemistry and Molecular Biology .

Hartl works in the fields of physiological chemistry, cell biology and biochemistry . He is particularly concerned with protein folding . He studied the process of folding in the cytosol in bacteria , archaea and eukaryotes and was able to provide evidence in 1989 that chaperones fold proteins. He researches why the activity of the chaperones decreases with age and how they can be reactivated. He is also investigating new therapeutic approaches for neurogenerative diseases that arise from incorrect folding or clumping of proteins, for example Alzheimer's , Parkinson's , Huntington's disease or prion diseases. He was able to show that certain chaperones can suppress the formation of incorrectly folded proteins in Huntington's disease. His chaperone research is also important for the biotechnological production of proteins, because the yield of functional proteins can be increased.

Hartl lives with his wife Manajit Hayer-Hartl, who also works as a biochemist, in Kottgeisering . Hartl plays the flute and piano.

Publications (selection)

  • The control of peroxisomal enzyme activities by thyroid hormone in the rat liver . DNB 850819857 , dissertation, Heidelberg 1985.
  • Topogenesis of Mitochondrial Proteins. Mechanisms of Sorting and Assembly of Proteins into the Mitochondrial Subcompartments . Habilitation thesis, Munich 1990.
  • as editor: Protein Targeting to Mitochondria . JAI Press, Greenwich, Conn. [u. a.] 1996 (= Advances in molecular and cell biology, Volume 17), ISBN 0-7623-0144-9
  • FU Hartl: Molecular Chaperones in Cellular Protein Folding . In: Nature . Volume 381, 1996, pp. 571-580, doi: 10.1038 / 381571a0 .
  • FU Hartl and M. Hayer-Hartl: Molecular chaperones in the cytosol. From nascent chain to folded protein . In: Science . Volume 295, 2002, pp. 1852-1858, doi: 10.1126 / science.1068408 .

Awards

Memberships

literature

Web links

Individual evidence

  1. ↑ Ming Y. Cheng, F.-Ulrich Hartl, Jörg Martin, Robert A. Pollock, Frantisek Kalousek, Walter Neupert, Elizabeth M. Hallberg, Richard L. Hallberg and Arthur L. Horwich : Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria . In: Nature . Volume 337, 1989, pp. 620-625, doi: 10.1038 / 337620a0 .
  2. ↑ Joachim Ostermann, Arthur L. Horwich, Walter Neupert and F.-Ulrich Hartl: Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis . In: Nature . Volume 341, 1989, pp. 125-130, doi: 10.1038 / 341125a0 .
  3. ↑ A. Sittler, R. Lurz, G. Lüder, J. Priller, MK Hayer-Hartl, H. Lehrach, FU Hartl and E. Wanker: Geldanamycin activates a heat shock response and inhibits Huntingtin aggregation in a cell culture model of Huntington's disease . In: Human Molecular Genetics . Volume 10, 2001, pp. 1307-1315, doi: 10.1093 / hmg / 10.12.1307 .
  4. ↑ Appointment: Prime Minister Seehofer hands out the Bavarian Order of Merit and the Federal Cross of Merit to distinguished personalities. (No longer available online.) In: bayern.de. Bavarian State Government, March 22, 2011, archived from the original on February 17, 2017 ; accessed on February 17, 2017 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / bayern.de
  5. ^ Lasker Foundation: Albert Lasker Basic Medical Research Award - Winners 2011 , accessed on September 12, 2011.
  6. ↑ Amy E. Hamaker: 2011 Massry Prize winners discuss protein folding ( Memento of the original from August 26, 2012 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. , October 17, 2011, accessed October 8, 2012. @1@ 2Template: Webachiv / IABot / keck.usc.edu
  7. ↑ F.-Ulrich Hartl receives the Herbert Tabor Research Prize from the Science Information Service (idw-online.de); Retrieved April 19, 2013.
  8. ↑ Ernst Schering Prize 2016
  9. ^ Paul Ehrlich Prize for researchers from Munich and the USA
  10. ^ Book of Members. (PDF) Retrieved July 23, 2016 (English).
  11. ↑ Member entry by Prof. Dr. F. Ulrich Hartl (with picture and CV) at the German Academy of Natural Scientists Leopoldina , accessed on July 11, 2016.
personal data
SURNAME Hartl, Franz-Ulrich
BRIEF DESCRIPTION German cell biologist and university professor
DATE OF BIRTH March 10, 1957
PLACE OF BIRTH eat