R. Heiner Schirmer

Rolf Heiner Schirmer (born February 1, 1942 in Bremen ; † September 20, 2016 ) was a German physician and biochemist . From 1980 until his retirement in 2007 he was Professor of Biochemistry in the Medical Faculty of the Ruprecht-Karls-Universität Heidelberg .

Life

After graduating from the old grammar school in Bremen, Schirmer studied medicine and philosophy at the universities of Heidelberg and Basel from 1961 to 1966 . In 1964 he worked on excitable membrane ion pumps in Plymouth , England . In 1966 he was at Caspar Rüegg at the Max Planck Institute for Medical Research on the specifics of the contractile proteins of the arteries doctorate . From 1967 to 1970 he served as a medical assistant in internal medicine , mainly at the Ludolf Krehl Clinic , Heidelberg , but also as a postdoctoral fellow at Dartmouth Medical School in New Hampshire . From 1970 to 1980 he was a scientific assistant at the Max Planck Institute for Medical Research, where, together with Georg E. Schulz, he carried out structural and pharmacological studies on nucleotide-binding enzymes . In 1975 he received his habilitation in biochemistry at the University of Heidelberg . Together with Schulz, he published the monograph Principles of Protein Structure (English 1979, Japan 1980, Russian 1982). In 1976 Schirmer worked as a bicentennial lecturer in Boston and Philadelphia .

1980 Schirmer followed a call to the Chair of Biochemistry in the Faculty of Medicine of the University of Heidelberg. His research areas included the biochemistry of parasitic cells in malaria and Chagas' cardiomyopathy as well as the enzyme structures of redox metabolism as targets for chemotherapy in parasitoses . Since 1987 he has worked in his research semesters at the Dana-Farber Cancer Institute in Boston and at the University of Michigan . From 1992 to 1993 he served as dean of the Faculty of Natural Science Medicine at Heidelberg University ; From 1998 to 2007 he was a specialist and specialist examiner for biochemistry, and from 2002 to 2007 he was an expert for biochemistry at the Institute for Medical and Pharmaceutical Examination Questions (IMPP) in Mainz.

Awards

In 2002 Professor Schirmer received the “Dream Action Award” from the Dutch chemical company DSM for the development and clinical testing of drug combinations containing methylene blue against malaria in children in West Africa . Since then, he has also been working as a founding member to set up the Center de Recherche en Santé de Nouna (CRSN), Burkina Faso .

Fonts

• with GE Schulz, M. Elzinga and F. Marx: Three-dimensional structure of adenyl kinase. In: Nature . 250, 1974, pp. 120-123.
• with GE Schulz: Topological comparison of adenyl kinase with other proteins. In: Nature. 250, 1974, pp. 142-144.
• with GE Schulz, W. Sachsenheimer and EF Pai: The structure of the flavoenzyme glutathione reductase. In: Nature. 273, 1978, pp. 120-124.
• with GE Schulz: Protein structures - the basis of molecular medicine. In: A look around in science and technology. 80, 1980, pp. 680-682 (introduction of the concept of molecular medicine).
• with GE Schulz: Principles of protein structure. Springer, New York 1978. (also in Japanese, NN-Verlag, Tokyo (1980), and in Russian, Mir, Moscow (1982)).
• with JG Müller and RL Krauth-Siegel: Disulfide-reductase inhibitors as chemotherapeutic agents: The design of drugs for trypanosomiasis and malaria. In: Angewandte Chemie International Edition 34, 1995, pp. 141–154. doi : 10.1002 / anie.199501411
• with K. Becker, SN Savvides, MA Keese and PA Karplus: Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers. In: Nature Structural Biology 5, 1998, pp. 267-271. PMID 9546215 .
• with SM Kanzok, A. Fechner, H. Bauer, JK Ulschmid, HM Müller, J. Botella-Munoz, S. Schneuwly and K. Becker: Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. In: Science . 291, 2001, pp. 643-646.
• with S. Gromer, L. Johansson, H. Bauer, LD Arscott, S. Rauch, DP Ballou, CH Williams Jr and ESJ Arnér: Active sites of thioredoxin reductases - why selenoproteins? In: Proceedings of the National Academy of Sciences . 100, 2003, pp. 12618-12623.
• with RL Krauth-Siegel and H. Bauer: Dithiol proteins as guardians of the intracellular redox milieu in parasites: Old and new drug targets in trypanosomes and malaria-causing plasmodia. In: Angewandte Chemie International Edition 44, 2005, pp. 690–715. doi : 10.1002 / anie.200300639
• with H. Adler, M. Pickhardt and E. Mandelkow: Read we forget you, methylene blue. In: Neurobiology of Aging. 32, 2325, 2011, pp. E7 – e2325, e16.
• with B. Coulibaly, M. Pritsch, M. Bountogo, PE Meissner, E. Nebié, C. Klose, M. Kieser, N. Berens-Riha, A. Wieser, SB Sirima, J. Breitkreutz, A. Sié, FP Mockenhaupt, C. Drakeley, T. Bousema and O. Müller: Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso. In: The Journal of Infectious Diseases . 211, 2015, pp. 689-697.

Web links

• R. Heiner Schirmer's curriculum vitae in the Biochemistry Center of Heidelberg University
• Research group led by R. Heiner Schirmer

Individual evidence

1. ^ Obituary notice , Rhein-Neckar-Zeitung , September 24, 2016, accessed on September 26, 2016.
2. ↑ yumpu.com
3. ↑ GE Schulz, RH Schirmer: Principles of Protein Structure.
4. ↑ TV broadcast on SAT1 on April 7, 2002 The Parasit Without Mercy - The Malaria Pathogen and Its Masks Report in the Information Service Science of April 5, 2002 accessed on December 29, 2017
5. ↑ gepris.dfg.de
6. ↑ medizinische-fakultaet-hd.uni-heidelberg.de ( Memento of the original March 5, 2016 Internet Archive ) Info: The archive link is automatically inserted and not yet tested. Please check the original and archive link according to the instructions and then remove this notice. 
7. ↑ yumpu.com
8. ↑ idw-online.de
9. ↑ crsn-nouna.bf
10. ↑ jid.oxfordjournals.org