John W. Kappler
John Wayne Kappler is an American biochemist and immunologist .
Life
Kappler earned a bachelor's degree in chemistry from Lehigh University in Bethlehem , Pennsylvania in 1965 and a Ph.D. in biochemistry with Gordon H. Sato at Brandeis University in Waltham , Massachusetts . As a postdoctoral fellow, he worked with Richard Dutton at the University of California, San Diego in La Jolla , California .
Kappler received his first junior professorship in oncology ( Assistant Professor 1973, Associate Professor 1978) at the University of Rochester in Rochester , New York . In 1979 he moved to National Jewish Health , a leading institution in immunological and allergological research based in Denver , Colorado . In 1980 he became Associate Professor of Microbiology and Immunology at the University of Colorado at Denver, 1984 Full Professor. Since 1986 Kappler has also been doing research for the Howard Hughes Medical Institute in Denver. In 1998 he also took over a professorship in pharmacology at the University of Colorado . Since 2001, his teaching and research activities in immunology for the University of Colorado and the National Jewish Medical and Research Center have been combined in a joint professorship.
Act
Together with his wife, the biochemist and immunologist Philippa Marrack , Kappler contributed important knowledge about the molecular basis of the recognition of antigens by T cells . Among other things, they were able to show that the T cell receptor consists of two subunits and recognizes both MHC molecules and antigens. They also described the T cell receptor and the time frame in which its gene rearrangement takes place, and were able to identify the elimination of T cell clones as the central mechanism of self-tolerance . These findings are fundamental to understanding autoimmune diseases , allergies , transplant rejection, and vaccinations .
Since 2019 the media group Clarivate has counted him among the favorites for a Nobel Prize ( Clarivate Citation Laureates ).
Awards (selection)
- 1989 membership in the National Academy of Sciences
- 1990 Wellcome Prize from the Royal Society
- 1993 Paul Ehrlich and Ludwig Darmstaedter Prize together with Philippa Marrack and Harald von Boehmer
- 1993 William B. Coley Award
- 1994 Louisa Gross Horwitz Prize together with Philippa Marrack
- 2015 Wolf Prize for Medicine together with Philippa Marrack and Jeffrey Ravetch
Web links
- John Kappler, PhD at ucdenver.edu
- J. Kappler, Ph.D. & P. Marrack, Ph.D. Research Laboratory at nationaljewish.org
- John W. Kappler, Ph.D. at hhmi.org
- John W Kappler, PhD at nationaljewish.org
Individual evidence
- ↑ a b John W. Kappler at nasonline.org; accessed on January 14, 2016.
- ^ Royal Society GlaxoSmithKline Prize and Lecture at the Royal Society (royalsociety.org); Retrieved July 22, 2013
- ^ Goethe University - laureate since 1952. In: uni-frankfurt.de. March 14, 2016, accessed January 23, 2016 .
- ^ William B. Coley Award. In: cancerresearch.org. Retrieved January 24, 2016 .
- ^ Two Immunologists Win the Horwitz Prize at columbia.edu; Retrieved January 7, 2011
| personal data | |
|---|---|
| SURNAME | Kappler, John W. |
| ALTERNATIVE NAMES | Kappler, John; Kappler, John Wayne (full name) |
| BRIEF DESCRIPTION | American biochemist and immunologist |
| DATE OF BIRTH | 20th century |