Ralph L. Brinster
Ralph Lawrence Brinster (born March 10, 1932 in Montclair , New Jersey ) is an American veterinarian and geneticist . He is Professor of Reproductive Physiology at the University of Pennsylvania at Philadelphia .
Life
Brinster acquired in 1953 a Bachelor of Agricultural School (School of Agriculture) of Rutgers University , New Jersey , in 1960 a VMD ( professional doctorate in veterinary medicine ) and in 1964 a Ph.D. in Physiology from the University of Pennsylvania at Philadelphia . As a postdoctoral fellow , he worked at the Jackson Laboratory in Bar Harbor , Maine , and the Marine Biological Laboratory in Woods Hole , Massachusetts . From 1960 he took on teaching duties in the Department of Physiology (Human Medicine) at the University of Pennsylvania. He received a professorship ( assistant professor 1965, associate professor 1966, full professorship 1970) in veterinary medicine at the University of Pennsylvania.
Act
With his work, Brinster laid the foundations for the development of transgenic organisms . He developed systems for the cultivation of egg cells, which are essential for the generation of transgenic animals. He was able to cultivate blastocysts from stem cells from older embryos and to breed adult chimeric mice by combining cells from teratocarcinomas with blastocyte cells . Brinster was the first to introduce foreign RNA into fertilized egg cells using microinjection and is one of the pioneers of microinjection technology in the development of transgenic mice.
Recent work concerned with the biology of the semen Togo African stem cell ( spermatogonial stem cell , SSC) of various species, its cultivation and transplantation .
Awards (selection)
- 1986 membership in the American Academy of Arts and Sciences
- 1987 membership in the National Academy of Sciences
- 1989 membership in the American Association for the Advancement of Science
- 1994 Prix Charles-Léopold Mayer of the Académie des sciences (together with Richard Palmiter )
- 1996 March of Dimes Prize in Developmental Biology
- 1997 Bower Award and Prize for Achievement in Science
- 2003 Wolf Prize in Medicine (with Mario Capecchi and Oliver Smithies )
- 2006 Gairdner Foundation International Award (with Ronald M. Evans , Alan Hall , Thomas D. Pollard , Joan Steitz )
- 2010 National Medal of Science
literature
- Who's Who in America. 66th Edition, Volume 1: A – L. Marquis Who's Who, Berkeley Heights 2011, ISBN 978-0-8379-7031-8 (Volume 1), ISBN 978-0-8379-7035-6 (complete work), ISSN 0083-9396 , p. 519
Web links
- Ralph Brinster at the University of Pennsylvania School of Veterinary Medicine (vet.upenn.edu); accessed on February 1, 2016.
Individual evidence
- ↑ Book of Members 1780 – present, Chapter B. (PDF; 1.2 MB) In: American Academy of Arts and Sciences (amacad.org). Retrieved April 18, 2018 .
- ^ Prix Charles-Léopold Mayer. List of award winners (PDF, 1.8 MB, status 2014) at academie-sciences.fr; accessed on February 1, 2016.
- ↑ The 2002/3 Wolf Prize in Medicine at wolffund.org.il; Retrieved March 20, 2011
- ↑ Ralph Brinster VMD, PhD at the Gairdner Foundation (gairdner.org); Retrieved December 14, 2012
| personal data | |
|---|---|
| SURNAME | Brinster, Ralph L. |
| ALTERNATIVE NAMES | Brinster, Ralph; Brinster, Ralph Lawrence (full name) |
| BRIEF DESCRIPTION | American veterinarian and geneticist |
| DATE OF BIRTH | March 10, 1932 |
| PLACE OF BIRTH | Montclair , New Jersey |