Nahum Sonenberg
Nahum Sonenberg (born December 29, 1946 in Wetzlar ) is an Israeli - Canadian biochemist and professor at McGill University in Montreal , Canada .
Life
Sonenberg earned bachelor's and master's degrees in microbiology and immunology from Tel Aviv University and a Ph.D. at the Weizmann Institute for Science in Rechovot , Israel . He worked as a postdoctoral fellow at the Roche Institute of Molecular Biology in Nutley , New Jersey . Since 1979 he has been at McGill University in Montreal , Canada , where he is now (as of 2011) Professor of Biochemistry .
Sonenberg is married and has two daughters.
Act
Sonenberg identified the eIF4E protein, which belongs to the 5'-cap structure of mRNA , and discovered the IRES mechanism for initiating translation in eukaryotes and the cap-dependent regulation of translation by eIF4E-binding proteins (4E-BP). He was able to show the proto-oncogene character of the eIF4E and that rapamycin (sirolimus) inhibits the eIF4E protein (see mTOR ). Through studies on 4E-BP knockout mice , Sonnenberg and co-workers were able to show that eIF4E plays an important role in the metabolism of adipose tissue , in innate immunity and in learning and memory processes .
Further work deals with virology : poliovirus , rhinoviruses and human immunodeficiency virus (HIV).
Awards (selection)
- 1992 membership in the Royal Society of Canada
- 2002 Robert L. Noble Prize
- 2005 Killam Prize
- 2006 membership in the Royal Society
- 2006 membership in the American Academy of Arts and Sciences
- 2009 Gairdner Foundation International Award
- 2010 Officer of the Order of Canada
- 2012 Rosenstiel Award
- 2012 Fellow of the American Association for the Advancement of Science
- 2014 Wolf Prize in Medicine
- 2015 member of the National Academy of Sciences
literature
- Who's Who 2012 . 164th edition. A & C Black, London 2011, ISBN 978-1-4081-4229-5 , pp. 2155 .
- The Canadian who's who. 43rd edition. University of Toronto Press, 2008, ISBN 978-0-8020-4071-8 , p. 1224. (excerpt)
Web links
- Sonenberg Laboratory at McGill University (mcgill.ca); Retrieved June 4, 2011
- Profile and Research Summary at the Howard Hughes Medical Institute (hhmi.org); accessed on February 7, 2016
Individual evidence
- ↑ Dr. Nahum Sonenberg at umbc.edu ( Memento from October 12, 2013 in the Internet Archive )
- ↑ Nahum Sonenberg at science.ca; Retrieved June 4, 2011.
- ^ Search Fellows - The Royal Society of Canada. In: rsc.ca. Retrieved February 8, 2016 .
- ^ Robert L. Noble Prize at cancer.ca; Retrieved June 4, 2011.
- ↑ Balbir Gill: McGill's three killam winners. In: mcgill.ca. April 14, 2005, accessed February 6, 2016 .
- ^ Fellows of the Royal Society (royalsociety.org); Retrieved June 4, 2011.
- ↑ Book of Members 1780–2010 (PDF, 432 kB) of the American Academy of Arts and Sciences (amacad.org); Retrieved June 4, 2011.
- ↑ Dr. Nahum Sonenberg, PhD at the Gairdner Foundation (gairdner.org); Retrieved December 4, 2012.
- ↑ Governor General announces 74 new appointments to the Order of Canada at gg.ca; Retrieved June 4, 2011.
| personal data | |
|---|---|
| SURNAME | Sonenberg, Nahum |
| BRIEF DESCRIPTION | Israeli-Canadian biochemist |
| DATE OF BIRTH | December 29, 1946 |
| PLACE OF BIRTH | Wetzlar |