Fosaprepitant

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Jynto (talk | contribs) at 18:40, 8 May 2015 (Adding space-filling model, adding alt text, tweaking image size). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Fosaprepitant
Skeletal formula of fosaprepitant
Space-filling model of the fosaprepitant molecule
Clinical data
AHFS/Drugs.comMultum Consumer Information
MedlinePlusa604003
License data
Routes of
administration
Intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailabilityn/a
Protein binding>95% (aprepitant)
MetabolismTo aprepitant
Elimination half-life9 to 13 hours (aprepitant)
Identifiers
  • [3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo- 2H-1,2,4-triazol-1-yl]phosphonic acid
CAS Number
PubChem CID
DrugBank
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H22F7N4O6P
Molar mass614.406 g/mol g·mol−1
 ☒NcheckY (what is this?)  (verify)

Fosaprepitant (Emend for Injection (US), Ivemend (EU)) is an antiemetic drug, administered intravenously. It is a prodrug of aprepitant.

Fosaprepitant was developed by Merck & Co. and was approved by the United States Food and Drug Administration (FDA) on January 25, 2008[1] and by the European Medicines Agency (EMA) on January 11 of the same year.[2]

See also

References

  1. ^ "Drugs.com, FDA Approves Emend (fosaprepitant dimeglumine) for Injection, Merck's New Intravenous Therapy, for Use in Combination with Other Antiemetics for Prevention of Nausea and Vomiting Caused by Chemotherapy". Retrieved 2008-03-15.
  2. ^ "European Public Assessment Report for Ivemend (from the EMEA website)". Retrieved 2008-03-15.

Template:Neuropeptide agonists and antagonists