Carolyn Bertozzi

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Carolyn Bertozzi in November 2011

Carolyn Ruth Bertozzi (born May 19, 1966 in Boston , Massachusetts ) is an American biochemist and university professor . She is a professor at Stanford University , where she holds the Anne T. and Robert M. Bass Chair at the School of Humanities and Sciences. In addition, since 2006 she has been Scientific Director for Biological Nanostructures at the Molecular Foundry of the Lawrence Berkeley National Laboratory .

Career

Carolyn Bertozzi is the daughter of the physicist and MIT professor William Bertozzi and his wife Norma. Her grandmother fled what was then fascist Italy to the United States in the 1920s. Carolyn Bertozzi grew up in Lexington (Massachusetts) and began as an undergraduate at Harvard with a degree in biology . Then she switched to organic chemistry . As part of her senior thesis - comparable to a diploma thesis - Bertozzi developed a photoacoustic calorimeter . For your thesis she transferred to the University of California, Berkeley , where she in 1993 Mark Bednarski on the topic Synthesis and biological activity of carbon-linked glycosides doctorate was. As a post-doctoral student , Bertozzi worked at the University of California, San Francisco, in the field of oligosaccharide- mediated cell adhesion . In 1996 she went back to Berkeley, where she was assistant professor of chemistry until 1999. From 1999 to 2002 Bertozzi was Associate Professor of Chemistry and Molecular and Cell Biology at Berkeley and Full Professor of Chemistry and Professor of Molecular and Cell Biology at the University of California, Berkeley ( TZ and Irmgard Chu Distinguished Professor ). Since 2000 she has also been Professor of Molecular and Cellular Pharmacology at the University of California, San Francisco (UCSF) and a scientist at the Howard Hughes Medical Institute ( Howard Hughes Medical Institute Investigator ). In 2015 she became a professor at Stanford University.

As the youngest scientist to date, Bertozzi received a MacArthur Fellowship in 1999 , the United States' “Genius Prize”. In 2010 she was the first woman to receive the Lemelson-MIT Prize, endowed with 500,000 US dollars (not earmarked) .

Carolyn Bertozzi has two sisters. One of them is the mathematician Andrea Bertozzi (* 1965).

plant

An example of the Staudinger ligation according to Bertozzi.

Bertozzi’s field of work mainly includes glycans . She developed her first so-called bioorthogonal marking , i.e. a chemical reaction that takes place in a living cell without disturbing the normal biochemical function of the respective target substance. With the help of this technology, it is possible to make certain target structures in living cells and higher organisms such as mice or zebrafish visible. To do this, she initially used a variant of the Staudinger reaction , the Staudinger ligation . With the Staudinger ligation, good labeling results can be obtained in vivo with cell cultures , but the reaction is too slow for in vivo applications (on living organisms). Bertozzi therefore developed the copper-free click chemistry , which is based on the 1,3-dipolar cycloaddition discovered by Rolf Huisgen . Bertozzi accelerated the azide - alkyne reaction by several orders of magnitude through the use of “pre-stressed” cyclooctynes provided with fluorine groups , so that it takes place almost quantitatively and bioorthogonally within a few minutes without a catalyst . The copper I catalyst otherwise used for click chemistry is toxic to cells and organisms. Bertozzi first coined the term bioorthogonal in 2000.

In 2008, Carolyn Bertozzi co-founded Redwood Bioscience with David Rabuka, one of her former students . Thomson Reuters has ranked Bertozzi among the favorites for a Nobel Prize in Chemistry since 2015 .

Awards and honors

Carolyn Bertozzi at the € 10,000 Emanuel Merck Lecture 2011

Bertozzi is a member of the National Academy of Sciences (2005), the Institute of Medicine (2011), the American Academy of Arts and Sciences and the German Academy of Natural Scientists Leopoldina (since 2008), as well as an external member of the Royal Society (since 2018).

Publications (selection)

Web links

Commons : Carolyn Bertozzi  - Collection of pictures, videos and audio files

Individual evidence

  1. ↑ Carolyn R. Bertozzi. Retrieved August 6, 2019 .
  2. ^ A b c T. Davis: Profile of Carolyn Bertozzi. In: PNAS. Volume 107, Number 7, pp. 2737-2739. doi : 10.1073 / pnas.0914469107
  3. ↑ mit.du: William Bertozzi - Professor of Physics. Retrieved November 15, 2011
  4. ^ Reactions - Carolyn Bertozzi. Retrieved November 15, 2011
  5. ↑ JJ Grabowski, CR Bertozzi, JR Jacobsen, A. Jain, EM Marzluff, AY Suh: Fluorescence probes in biochemistry: an examination of the non-fluorescent behavior of dansylamide by photoacoustic calorimetry. In: Analytical biochemistry . Volume 207, Number 2, December 1992, pp. 214-226, ISSN  0003-2697 . PMID 1481973 .
  6. ↑ a b scheringstiftung.de: Prize winner Prof. Carolyn R. Bertozzi. ( Memento of the original from January 3, 2011 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved November 15, 2011 @1@ 2Template: Webachiv / IABot / www.scheringstiftung.de
  7. ↑ innovations-report.de: Assembling cells into artificial 3-D microtissues, including a tiny gland. March 26, 2009
  8. ↑ lemelson.org: Chemical biologist and entrepreneur Carolyn Bertozzi Awarded $ 500,000 Lemelson-MIT Prize. ( Memento of June 5, 2010 in the Internet Archive ) Retrieved November 15, 2011
  9. ^ EH Oakes: Encyclopedia of world scientists. Volume 1, Infobase Publishing, 2007, ISBN 0-816-06158-0 limited preview in Google Book Search
  10. ^ EM Sletten, CR Bertozzi: Bioorthogonale Chemie - or: fishing for selectivity in a sea of ​​functionality. In: Angewandte Chemie. Volume 121, Number 38, 2009, pp. 7108-7133. doi : 10.1002 / anie.200900942 .
  11. ↑ M. Köhn, R. Breinbauer: The Staudinger ligation - a gift for chemical biology. In: Angewandte Chemie. Volume 116, Number 24, 2004, pp. 3168-3178. doi : 10.1002 / anie.200401744
  12. ↑ C. Erger, M. Marek u. a .: The Staudinger ligation - a gift for chemical biology. (PDF; 166 kB) University of Marburg, accessed on November 15, 2011
  13. ↑ W. Peters: New applications of (S) -adenosyl-L-methionine analogues with protein methyltransferases and click chemistry for the sequence-specific labeling of proteins. (PDF; 5.5 MB) Dissertation, RWTH Aachen, 2009, p. 23.
  14. ↑ 2010 Winner of the $ 500,000 Lemelson-MIT Prize: Dr. Carolyn Bertozzi. (PDF; 1.6 MB) Retrieved November 15, 2011
  15. ^ E. Saxon, CR Bertozzi: Cell surface engineering by a modified Staudinger reaction. In: Science. Volume 287, Number 5460, March 2000, pp. 2007-2010, ISSN  0036-8075 . PMID 10720325 .
  16. ^ S. Martinovich: Chemical biologist and entrepreneur Carolyn Bertozzi awarded the $ 500,000 Lemelson-MIT Prize. From June 2, 2010
  17. ↑ Announcing the 2015 Citation Laureates , at Thomson Reuters.
  18. ↑ a b c d e f g h i j Carolyn R. Bertozzi. University of California, Berkeley. Retrieved November 15, 2011
  19. ^ Past Fellows. Alfred P. Sloan Foundation, accessed August 20, 2019 .
  20. ↑ a b c d e f g h i j k l m n o J. Bertola: Carolyn R. Bertozzi. The Rochester Section ACS, accessed November 15, 2011
  21. ↑ rsc.org: Professor Carolyn R Bertozzi. ( Memento of the original from January 18, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved November 15, 2011 @1@ 2Template: Webachiv / IABot / www.rsc.org
  22. ^ TU Darmstadt: Carolyn Bertozzi Prize Winner of the Emanuel Merck Lecture 2011. Accessed on November 15, 2011
  23. ↑ JM Baskin, CR Bertozzi: Copper-Free Click Chemistry: Bioorthogonal Reagents for Tagging Azides. (PDF; 3.8 MB) In: Aldrichimica Acta . Volume 43, Number 1, 2010, pp. 15-23.
  24. ↑ Member entry by Prof. Ph.D. Carolyn Bertozzi (with CV) at the German Academy of Natural Scientists Leopoldina , accessed on June 29, 2016.
personal data
SURNAME Bertozzi, Carolyn
ALTERNATIVE NAMES Bertozzi, Carolyn Ruth
BRIEF DESCRIPTION American biochemist
DATE OF BIRTH May 19, 1966
PLACE OF BIRTH Boston , Massachusetts