Carolyn Bertozzi
Carolyn Ruth Bertozzi (born May 19, 1966 in Boston , Massachusetts ) is an American biochemist and university professor . She is a professor at Stanford University , where she holds the Anne T. and Robert M. Bass Chair at the School of Humanities and Sciences. In addition, since 2006 she has been Scientific Director for Biological Nanostructures at the Molecular Foundry of the Lawrence Berkeley National Laboratory .
Career
Carolyn Bertozzi is the daughter of the physicist and MIT professor William Bertozzi and his wife Norma. Her grandmother fled what was then fascist Italy to the United States in the 1920s. Carolyn Bertozzi grew up in Lexington (Massachusetts) and began as an undergraduate at Harvard with a degree in biology . Then she switched to organic chemistry . As part of her senior thesis - comparable to a diploma thesis - Bertozzi developed a photoacoustic calorimeter . For your thesis she transferred to the University of California, Berkeley , where she in 1993 Mark Bednarski on the topic Synthesis and biological activity of carbon-linked glycosides doctorate was. As a post-doctoral student , Bertozzi worked at the University of California, San Francisco, in the field of oligosaccharide- mediated cell adhesion . In 1996 she went back to Berkeley, where she was assistant professor of chemistry until 1999. From 1999 to 2002 Bertozzi was Associate Professor of Chemistry and Molecular and Cell Biology at Berkeley and Full Professor of Chemistry and Professor of Molecular and Cell Biology at the University of California, Berkeley ( TZ and Irmgard Chu Distinguished Professor ). Since 2000 she has also been Professor of Molecular and Cellular Pharmacology at the University of California, San Francisco (UCSF) and a scientist at the Howard Hughes Medical Institute ( Howard Hughes Medical Institute Investigator ). In 2015 she became a professor at Stanford University.
As the youngest scientist to date, Bertozzi received a MacArthur Fellowship in 1999 , the United States' “Genius Prize”. In 2010 she was the first woman to receive the Lemelson-MIT Prize, endowed with 500,000 US dollars (not earmarked) .
Carolyn Bertozzi has two sisters. One of them is the mathematician Andrea Bertozzi (* 1965).
plant
Bertozzi’s field of work mainly includes glycans . She developed her first so-called bioorthogonal marking , i.e. a chemical reaction that takes place in a living cell without disturbing the normal biochemical function of the respective target substance. With the help of this technology, it is possible to make certain target structures in living cells and higher organisms such as mice or zebrafish visible. To do this, she initially used a variant of the Staudinger reaction , the Staudinger ligation . With the Staudinger ligation, good labeling results can be obtained in vivo with cell cultures , but the reaction is too slow for in vivo applications (on living organisms). Bertozzi therefore developed the copper-free click chemistry , which is based on the 1,3-dipolar cycloaddition discovered by Rolf Huisgen . Bertozzi accelerated the azide - alkyne reaction by several orders of magnitude through the use of “pre-stressed” cyclooctynes provided with fluorine groups , so that it takes place almost quantitatively and bioorthogonally within a few minutes without a catalyst . The copper I catalyst otherwise used for click chemistry is toxic to cells and organisms. Bertozzi first coined the term bioorthogonal in 2000.
In 2008, Carolyn Bertozzi co-founded Redwood Bioscience with David Rabuka, one of her former students . Thomson Reuters has ranked Bertozzi among the favorites for a Nobel Prize in Chemistry since 2015 .
Awards and honors
- 1987: Phi Beta Kappa
- 1988: Institute of Chemists Award
- 1997: Sloan Research Fellowship
- 1999: MacArthur Foundation Fellowship
- 1999: Arthur C. Cope Scholar Award (ACS)
- 1999: Camille Dreyfus Teacher-Scholar Award
- 2000: UC Berkeley Department of Chemistry Teaching Award
- 2000: Merck Academic Development Program Award
- 2000: Presidential Early Career Award in Science and Engineering (PECASE)
- 2001: Berkeley's Distinguished Teaching Award
- 2001: Donald Sterling Noyce Prize for Excellence in Undergraduate Teaching
- 2001: ACS Award in Pure Chemistry
- 2002: Irving Sigal Young Investigator Award of the Protein Society
- 2002: Fellow of the American Association for the Advancement of Science
- 2004: Agnes Fay Morgan Research Award from Iota Sigma Pi
- 2005: Havinga Medal from the University of Leiden
- 2005: TZ and Irmgard Chu Distinguished Professorship in Chemistry
- 2007: Ernst Schering Prize , for her outstanding research on the function of sugar residues on proteins in the field of glycobiochemistry
- 2008: Li Ka-shing Women in Science Award
- 2008: Willard Gibbs Medal
- 2008: Roy L. Whistler Award
- 2009: Harrison Howe Award
- 2009: Albert Hofmann Gold Medal from the University of Zurich
- 2009: WH Nichols Award
- 2010: ACS Award in Pure Chemistry
- 2010: Lemelson-MIT Prize
- 2010: Bioorganic Chemistry Award from the Royal Society of Chemistry - Organic Division
- 2011: Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry
- 2011: Emanuel Merck Lecture 2011
- 2012: Heinrich Wieland Prize
- 2014: Ernest Orlando Lawrence Prize
- 2016: NAS Award in Chemical Sciences
- 2017: Arthur C. Cope Award
- 2017: National Inventors Hall of Fame
- 2020: John J. Carty Award
- 2020: Glenn T. Seaborg Medal
- 2020: FA Cotton Medal
Bertozzi is a member of the National Academy of Sciences (2005), the Institute of Medicine (2011), the American Academy of Arts and Sciences and the German Academy of Natural Scientists Leopoldina (since 2008), as well as an external member of the Royal Society (since 2018).
Publications (selection)
- PG Wang, CR Bertozzi (Eds.): Glycochemistry: principles, synthesis, and applications. Marcel Dekker Verlag, 2001, ISBN 0-8247-0538-6
- JM Baskin, CR Bertozzi: Copper-free Click Chemistry. In: J. Lahann (Ed.): Click Chemistry for Biotechnology and Materials Science. Publisher John Wiley & Sons, 2009, ISBN 0-470-69970-1 limited preview in Google Book Search
- EM Sletten, CR Bertozzi: From mechanism to mouse: a tale of two bioorthogonal reactions. In: Accounts of chemical research. Volume 44, Number 9, September 2011, pp. 666-676, ISSN 1520-4898 . doi : 10.1021 / ar200148z . PMID 21838330 . PMC 3184615 (free full text).
- EM Sletten, CR Bertozzi: A bioorthogonal quadricyclane ligation. In: Journal of the American Chemical Society. Volume 133, Number 44, November 2011, pp. 17570-17573, ISSN 1520-5126 . doi : 10.1021 / ja2072934 . PMID 21962173 . PMC 3206493 (free full text).
- CR Bertozzi: A decade of bioorthogonal chemistry. In: Accounts of chemical research. Volume 44, Number 9, September 2011, pp. 651-653, ISSN 1520-4898 . doi : 10.1021 / ar200193f . PMID 21928847 .
- K. Godula, ML Umbel, D. Rabuka, Z. Botyanszki, CR Bertozzi, R. Parthasarathy: Control of the molecular orientation of membrane-anchored biomimetic glycopolymers. In: Journal of the American Chemical Society. Volume 131, Number 29, July 2009, pp. 10263-10268, ISSN 1520-5126 . doi : 10.1021 / ja903114g . PMID 19580278 . PMC 2716393 (free full text).
- ST Laughlin, JM Baskin, SL Amacher, CR Bertozzi: In vivo imaging of membrane-associated glycans in developing zebrafish. In: Science . Volume 320, Number 5876, May 2008, pp. 664-667, ISSN 1095-9203 . doi : 10.1126 / science.1155106 . PMID 18451302 . PMC 2701225 (free full text).
- CW Harland, D. Rabuka, CR Bertozzi, R. Parthasarathy: The Mycobacterium tuberculosis virulence factor trehalose dimycolate imparts desiccation resistance to model mycobacterial membranes. In: Biophysical Journal. Volume 94, Number 12, June 2008, pp. 4718-4724, ISSN 1542-0086 . doi : 10.1529 / biophysj.107.125542 . PMID 18326657 . PMC 2397374 (free full text).
- JA Prescher, CR Bertozzi: Chemistry in living systems. In: Nature Chemical Biology . Volume 1, 2005, pp. 13-21. doi : 10.1038 / nchembio0605-13
- JA Prescher, DH Dube, CR Bertozzi: Chemical remodelling of cell surfaces in living animals. In: Nature . Volume 430, Number 7002, August 2004, pp. 873-877, ISSN 1476-4687 . doi : 10.1038 / nature02791 . PMID 15318217 .
- HC Hang, C. Yu, DL Kato, CR Bertozzi: A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation. In: Proceedings of the National Academy of Sciences . Volume 100, Number 25, December 2003, pp. 14846-14851, ISSN 0027-8424 . doi : 10.1073 / pnas.2335201100 . PMID 14657396 . PMC 299823 (free full text).
- KL Kiick, E. Saxon, DA Tirrell, CR Bertozzi: Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation. In: Proceedings of the National Academy of Sciences . Volume 99, Number 1, January 2002, pp. 19-24, ISSN 0027-8424 . doi : 10.1073 / pnas.012583299 . PMID 11752401 . PMC 117506 (free full text).
- LK Mahal, NW Charter, K. Angata, M. Fukuda, DE Koshland, CR Bertozzi: A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells. In: Science. Volume 294, Number 5541, October 2001, pp. 380-381, ISSN 0036-8075 . doi : 10.1126 / science.1062192 . PMID 11598302 .
- CR Bertozzi, LL Kiessling: Chemical glycobiology. In: Science. Volume 291, Number 5512, March 2001, pp. 2357-2364, ISSN 0036-8075 . PMID 11269316 . (Review).
- LK Mahal, KJ Yarema, CR Bertozzi: Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis. In: Science. Volume 276, Number 5315, May 1997, pp. 1125-1128, ISSN 0036-8075 . PMID 9173543 .
Web links
Individual evidence
- ↑ Carolyn R. Bertozzi. Retrieved August 6, 2019 .
- ^ A b c T. Davis: Profile of Carolyn Bertozzi. In: PNAS. Volume 107, Number 7, pp. 2737-2739. doi : 10.1073 / pnas.0914469107
- ↑ mit.du: William Bertozzi - Professor of Physics. Retrieved November 15, 2011
- ^ Reactions - Carolyn Bertozzi. Retrieved November 15, 2011
- ↑ JJ Grabowski, CR Bertozzi, JR Jacobsen, A. Jain, EM Marzluff, AY Suh: Fluorescence probes in biochemistry: an examination of the non-fluorescent behavior of dansylamide by photoacoustic calorimetry. In: Analytical biochemistry . Volume 207, Number 2, December 1992, pp. 214-226, ISSN 0003-2697 . PMID 1481973 .
- ↑ a b scheringstiftung.de: Prize winner Prof. Carolyn R. Bertozzi. ( Memento of the original from January 3, 2011 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved November 15, 2011
- ↑ innovations-report.de: Assembling cells into artificial 3-D microtissues, including a tiny gland. March 26, 2009
- ↑ lemelson.org: Chemical biologist and entrepreneur Carolyn Bertozzi Awarded $ 500,000 Lemelson-MIT Prize. ( Memento of June 5, 2010 in the Internet Archive ) Retrieved November 15, 2011
- ^ EH Oakes: Encyclopedia of world scientists. Volume 1, Infobase Publishing, 2007, ISBN 0-816-06158-0 limited preview in Google Book Search
- ^ EM Sletten, CR Bertozzi: Bioorthogonale Chemie - or: fishing for selectivity in a sea of functionality. In: Angewandte Chemie. Volume 121, Number 38, 2009, pp. 7108-7133. doi : 10.1002 / anie.200900942 .
- ↑ M. Köhn, R. Breinbauer: The Staudinger ligation - a gift for chemical biology. In: Angewandte Chemie. Volume 116, Number 24, 2004, pp. 3168-3178. doi : 10.1002 / anie.200401744
- ↑ C. Erger, M. Marek u. a .: The Staudinger ligation - a gift for chemical biology. (PDF; 166 kB) University of Marburg, accessed on November 15, 2011
- ↑ W. Peters: New applications of (S) -adenosyl-L-methionine analogues with protein methyltransferases and click chemistry for the sequence-specific labeling of proteins. (PDF; 5.5 MB) Dissertation, RWTH Aachen, 2009, p. 23.
- ↑ 2010 Winner of the $ 500,000 Lemelson-MIT Prize: Dr. Carolyn Bertozzi. (PDF; 1.6 MB) Retrieved November 15, 2011
- ^ E. Saxon, CR Bertozzi: Cell surface engineering by a modified Staudinger reaction. In: Science. Volume 287, Number 5460, March 2000, pp. 2007-2010, ISSN 0036-8075 . PMID 10720325 .
- ^ S. Martinovich: Chemical biologist and entrepreneur Carolyn Bertozzi awarded the $ 500,000 Lemelson-MIT Prize. From June 2, 2010
- ↑ Announcing the 2015 Citation Laureates , at Thomson Reuters.
- ↑ a b c d e f g h i j Carolyn R. Bertozzi. University of California, Berkeley. Retrieved November 15, 2011
- ^ Past Fellows. Alfred P. Sloan Foundation, accessed August 20, 2019 .
- ↑ a b c d e f g h i j k l m n o J. Bertola: Carolyn R. Bertozzi. The Rochester Section ACS, accessed November 15, 2011
- ↑ rsc.org: Professor Carolyn R Bertozzi. ( Memento of the original from January 18, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved November 15, 2011
- ^ TU Darmstadt: Carolyn Bertozzi Prize Winner of the Emanuel Merck Lecture 2011. Accessed on November 15, 2011
- ↑ JM Baskin, CR Bertozzi: Copper-Free Click Chemistry: Bioorthogonal Reagents for Tagging Azides. (PDF; 3.8 MB) In: Aldrichimica Acta . Volume 43, Number 1, 2010, pp. 15-23.
- ↑ Member entry by Prof. Ph.D. Carolyn Bertozzi (with CV) at the German Academy of Natural Scientists Leopoldina , accessed on June 29, 2016.
personal data | |
---|---|
SURNAME | Bertozzi, Carolyn |
ALTERNATIVE NAMES | Bertozzi, Carolyn Ruth |
BRIEF DESCRIPTION | American biochemist |
DATE OF BIRTH | May 19, 1966 |
PLACE OF BIRTH | Boston , Massachusetts |