At the EHF Challenge Cup 2015/16 42 took Handball part -Vereinsmannschaften, who had qualified in the previous season in their home countries for the competition. It was the 16th edition of the Challenge Cup. The defending champion was the Romanian team HC Odorheiu Secuiesc . The cup games began on October 10, 2015, the second final took place on May 21, 2016. In the final with two Portuguese teams, ABC Braga was able to prevail against Benfica Lisbon .
The competition started with round 2 with 10 games. In the next round of 16 games, other, higher-rated teams got on. All rounds were played in a knockout system . The winner of the final was the winner of the EHF Challenge Cup in the 2015/16 season.
*AO Poseidon Loutrakiou moved into the round of 32 due to the away goals rule .
Sixteenth finals
total
First leg
Return leg
Handball Esch Luxembourg
48: 55
NetherlandsHV Aalsmeer
26:30
22:25
AO Poseidon Loutrakiou Greece
45: 46
BelgiumKV Sasja HC
23:24
22:22
ABC BragaPortugal
85 : 43
Estonia HC Kehra Tallinn
40:29
45:14
RK Čelik Zenica Bosnia and Herzegovina
55: 83
SwitzerlandWacker Thun
27:42
28:41
Neva St. PetersburgRussia
61 : 49
Turkey BB Ankara Spor
30:26
31:23
Benfica LisbonPortugal
57 : 40
Greece AS Filippos Verias
34:14
23:26
Fyllingen mountainsNorway
68 : 47
Serbia RK Radnički Kragujevac
35:28
33:19
Dukla PragueCzech Republic
68 : 60
Belgium HC Visé BM
38:27
30:33
Quarter finals
total
First leg
Return leg
Fyllingen mountainsNorway
55 : 48
Netherlands HV Aalsmeer
31:20
24:28
ABC BragaPortugal
64 : 57
Switzerland Wacker Thun
30:23
34:34
Benfica LisbonPortugal
49 : 47
Russia Neva St. Petersburg
24:20
25:27
KV Sasja HC Belgium
50: 56
Czech RepublicDukla Prague
27:27
23:29
Semifinals
total
First leg
Return leg
Benfica LisbonPortugal
64 : 49
Norway Fyllingen mountains
35:22
29:27
ABC BragaPortugal
67 : 62
Czech Republic Dukla Prague
34:33
33:29
final
The first leg took place on May 14, 2016 in Lisbon and the second leg on May 21, 2016 in Braga . In the fourth participation in a European final, including the year before in this competition and in the premiere season of the EHF Champions League , ABC Braga was able to win its first title.