Dienestrol: Difference between revisions
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| IUPAC_name = 4-[4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol; ''p''-[(''E,E'')-1-Ethylidene-2-(''p''-hydroxyphenyl)-2-butenyl]phenol |
| IUPAC_name = 4-[4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol; ''p''-[(''E,E'')-1-Ethylidene-2-(''p''-hydroxyphenyl)-2-butenyl]phenol |
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| image = Dienestrol.svg |
| image = Dienestrol.svg |
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<!--Identifiers--> |
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| IUPHAR_ligand = 7160 |
| IUPHAR_ligand = 7160 |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 1018 |
| ChEMBL = 1018 |
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<!--Chemical data--> |
<!--Chemical data--> |
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| C=18 | H=18 | O=2 |
| C=18 | H=18 | O=2 |
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| StdInChIKey = NFDFQCUYFHCNBW-SCGPFSFSSA-N |
| StdInChIKey = NFDFQCUYFHCNBW-SCGPFSFSSA-N |
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'''Dienestrol''' is a synthetic [[estrogen]]. |
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'''Dienestrol''' ([[International Nonproprietary Name|INN]], [[United States Adopted Name|USAN]]) (brand names '''Ortho Dienestrol''', '''Dienoestrol''', '''Dienoestrol Ortho''', '''Sexadien''', '''Denestrolin''', '''Dienol''', '''Dinovex''', '''Follormon''', '''Oestrodiene''', '''Synestrol''', numerous others), also known as '''dienoestrol''' ([[British Approved Name|BAN]]), is a [[synthetic]], [[non-steroidal]] [[estrogen]] used to treat [[menopause|menopausal]] symptoms in the [[United States]] and [[Europe]].<ref>{{cite book|title=Index Nominum 2000: International Drug Directory|url=http://books.google.com/books?id=5GpcTQD_L2oC&pg=PA331|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=331–}}</ref><ref name="Elks2014">{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=http://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA390|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=390–}}</ref><ref name="Muller1998">{{cite book|author=Muller|title=European Drug Index: European Drug Registrations, Fourth Edition|url=http://books.google.com/books?id=2HBPHmclMWIC&pg=PA361|date=19 June 1998|publisher=CRC Press|isbn=978-3-7692-2114-5|pages=361–}}</ref><ref name="Publishing2013">{{cite book|author=William Andrew Publishing|title=Pharmaceutical Manufacturing Encyclopedia, 3rd Edition|url=http://books.google.com/books?id=_J2ti4EkYpkC&pg=PA1286|date=22 October 2013|publisher=Elsevier|isbn=978-0-8155-1856-3|pages=1286–}}</ref> It was introduced in the U.S. in 1947 by [[Schering]] as '''Synestrol''' and in France in 1948 as '''Cycladiene'''.<ref name="Publishing2013" /> Dienestrol is a member of the [[stilbene]] group of synthetic estrogens, and is a close [[structural analog|analogue]] of [[diethylstilbestrol]].<ref>{{cite book|title=VITAMINS AND HORMONES|url=http://books.google.com/books?id=7PrzbzO-Q2AC&pg=PA233|date=1 January 1945|publisher=Academic Press|isbn=978-0-08-086600-0|pages=233–}}</ref> |
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[[Dienestrol diacetate]] (brand names Faragynol, Gynocyrol, others) also exists and is used medically.<ref name="Elks2014" /> |
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==See also== |
==See also== |
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*[[ |
* [[Benzestrol]] |
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* [[Broparestrol]] |
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* [[Fosfestrol]] |
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* [[Hexestrol]] |
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==References== |
==References== |
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{{ |
{{Reflist|2}} |
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{{Estrogens}} |
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{{Estrogenics}} |
{{Estrogenics}} |
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| ⚫ | |||
[[Category:Phenols]] |
[[Category:Phenols]] |
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| ⚫ | |||
Revision as of 00:17, 29 December 2015
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| Clinical data | |
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| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| ATC code | |
| Pharmacokinetic data | |
| Protein binding | 50 to 80% |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.001.381 |
| Chemical and physical data | |
| Formula | C18H18O2 |
| Molar mass | 266.334 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Dienestrol (INN, USAN) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others), also known as dienoestrol (BAN), is a synthetic, non-steroidal estrogen used to treat menopausal symptoms in the United States and Europe.[1][2][3][4] It was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene.[4] Dienestrol is a member of the stilbene group of synthetic estrogens, and is a close analogue of diethylstilbestrol.[5]
Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) also exists and is used medically.[2]
See also
References
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 331–. ISBN 978-3-88763-075-1.
- ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 390–. ISBN 978-1-4757-2085-3.
- ^ Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 361–. ISBN 978-3-7692-2114-5.
- ^ a b William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1286–. ISBN 978-0-8155-1856-3.
- ^ VITAMINS AND HORMONES. Academic Press. 1 January 1945. pp. 233–. ISBN 978-0-08-086600-0.
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