Detlev Ganten

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Detlev Ganten (2017)

Detlev Ganten (born March 28, 1941 in Lüneburg ) is a specialist in pharmacology and clinical pharmacology. He has been President of the World Health Summit since 2009 . From 1973 to 1991 he was professor at the Pharmacological Institute of Heidelberg University and from 1997 to 2001 chairman of the Helmholtz Association of German Research Centers. From 1991 to 2004 Ganten was founding director of the Max Delbrück Center for Molecular Medicine (MDC) in Berlin-Buch . From 2004 to 2008 he was chairman of the board of the new Charité - Universitätsmedizin Berlin and from 2005 to 2015 he was chairman of the foundation board of the Charité foundation; since 2016 he has been its honorary chairman.

Life

Ganten grew up in Bremen and trained as an agricultural assistant in Elmshorn , which he completed in 1959. He then studied medicine in Würzburg from 1962 and passed the Physikum there in 1964 . From 1964 to 1965 he continued his medical studies in Montpellier ( France ) before working in the surgical department of the French hospital Mamounia in Marrakech ( Morocco ). From 1966 to 1968 he continued his medical studies in Tübingen and finished his studies there with the medical state examination .

In 1968 he received his doctorate in the surgical clinic of the University of Tübingen. The subsequent medical assistant time in 1968/69 took place in internal medicine in Tübingen and in gynecology and obstetrics at the Emden Municipal Hospital . In 1970 he received his license to practice medicine . From 1969 to 1973 a research stay at the Clinical Research Institute in Montréal , Canada followed. In 1973 he was awarded the Doctor of Philosophy (PhD) at McGill University in Montréal for his scientific work there. From 1973 to 1991 worked Ganten of Pharmacology at the University of Heidelberg and his habilitation in 1974 of Experimental Medicine. In 1975 he received a professorship in Heidelberg and in 1978 he was recognized as a specialist in pharmacology.

After German reunification, Ganten was appointed founding director of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch by the Federal Minister of Research in 1991 with the task of reorganizing the central institutes of the GDR Academy of Sciences there. In 1993 he also took over the chair for clinical pharmacology at the Medical Faculty of the Free University of Berlin. From 1997 to 2001 he was chairman of the Helmholtz Association of German Research Centers, to which the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch belongs.

In 2004, Ganten was appointed chairman of the board of the Charité-Universitätsmedizin Berlin by the Senate of the City of Berlin Unite the roof of the new "Charité - Universitätsmedizin Berlin". On September 1, 2008, he handed over the position of chairman of the board to the former chairman of the Science Council, Professor Karl Max Einhäupl .

In 2009, on the occasion of the 300th anniversary of the Charité, Ganten launched the World Health Summit , which has been held annually in Berlin since then. The academic backbone of this international global health conference is the "M8 Alliance of Academic Health Centers, Universities and National Academies".

Detlev Ganten, Eckart von Hirschhausen , Maja Göpel , Gregor Hagedorn , Karen Helen Wiltshire and Volker Quaschning (from left to right) at the presentation of the # Scientists4Future statement on March 12, 2019 in Berlin before the federal press conference

Since spring 2019, Ganten has been involved in the Scientists for Future initiative together with other scientists .

Research areas

Ganten's research areas are primarily in the study of blood pressure regulation and the causes of high blood pressure . He clarified the basic mechanisms of the development of cardiovascular diseases and hypertension and was particularly concerned with the hormonal regulation and treatment of high blood pressure, especially the renin-angiotensin system . From this research new effective drugs for the treatment of high blood pressure and its sequelae, vascular damage, arteriosclerosis, stroke, kidney failure, myocardial infarction and heart failure have emerged. Ganten has used methods of molecular genetics, genomics and molecular analysis, especially transgenic techniques, in his research and further developed them for pharmacological and medical issues.

In addition, he worked on the evolution of genes for cardiovascular regulation and participated in the development of the concept of evolutionary medicine and a holistic, holistic approach to health and disease.

Awards

Memberships, positions

Detlev Ganten is a member of the Heidelberg Academy of Sciences , the Berlin-Brandenburg Academy of Sciences (BBAW), the German Academy of Natural Scientists Leopoldina , the Académie de Berlin, the Academia Europaea , the Polish Academy of Learning (PAU) in Krakow , the Polish Academy of Sciences in Warsaw, the Académie Nationale de Médecine in Paris, the Collège de France and the Russian Academy of Sciences .

Detlev Ganten has held the following functions and offices:

  • 1992–1998: President of the World Hypertension League
  • 1992–1997: Member of the Health Research Council of the Federal Ministry for Research and Technology
  • 1993–1998: Member of the Science Council of the Federal Republic of Germany
  • 1996–1998: President of the Society of German Natural Scientists and Doctors (GDNÄ)
  • 1997–2001: Chairman of the Hermann von Helmholtz Association of German Research Centers
  • 2001–2007: Member of the National Ethics Council
  • 2004–2012: President of the Comité international d'orientation scientifique et stratégique (COSS) of the Collège de France
  • 2013–2018: Co-Chair, Interacademy Partnership (IAP) for Health
  • 2011–2019 member of the Board of Directors of the University of Paris Sciences et Lettres (PSL).

Current functions:

  • Since 2009 chairman of the board of trustees of the Max Planck Institute for Colloids and Interfaces Research (MPI-KG) and the Max Planck Institute for Molecular Plant Physiology (MPI-MP) in Potsdam.
  • Since 2011 member of the Scientific Advisory Board of the Sorbonne University Paris Cité (France).
  • Since 2009 Founding President of the World Health Summit .
  • Since 2009 founding member and project manager of the "Genshagener Kreis".
  • Honorary Chairman of the Foundation Board of the Charité Foundation since 2016.
  • Since 2017 honorary member of the Max Delbrück Center for Molecular Medicine (MDC) Berlin Buch.
  • Since 2018 board member of the German Society of Members of the French Legion of Honor and the French National Order of Merit e. V.

Editor, Editorial Board

Publications (selection)

  • with K. Hayduk, HM Brecht, R. Boucher, J. Genest: Evidence of renin release or production in splanchnic territory. In: Nature . No. 226, 1970, pp. 551-552.
  • with JL Minnich, P. Granger, K. Hayduk, HM Brecht, A. Barbeau, R. Boucher, J. Genest: Angiotensin-forming enzyme in brain tissue. In: Science . No. 173, 1971, pp. 64-65.
  • with MI Phillips, Mann, JFE, H. Haebara, WE Hoffman, R. Dietz, P. Schelling: Lowering of hypertension by central saralasin in the absence of plasma renin. In: Nature . No. 270, 1977, pp. 445-447.
  • with RE Lang, Thölken, H., FC Luft, H. Ruskoaho, T. Unger: Atrial natriuretic factor: a circulating hormone stimulated by volume loading. In: Nature . No. 314, 1985, pp. 264-266, PMID 3157062 .
  • with U. Ganten, Schröder, G., M. Witt, F. Zimmermann, G. Stock: Sexual dimorphism of blood pressure in spontaneously hyperptensive rats: effects of anti-androgen treatment. In: J. Hypertens. No. 7, 1989, pp. 721-726, PMID 2529310 .
  • with E. Hackenthal, M. Paul, R. Taugner: Morphology, physiology, and molecular biology of renin secretion. In: Physiol Rev . No. 70, 1990, pp. 1067-1116.
  • with JJ Mullins, J. Peters: Fulminant hypertensin in transgenic rats harboring the mouse Ren-2 gene. In: Nature . No. 344, 1990, pp. 541-544, PMID 2181319 .
  • with P. Hilbert, K. Lindpaintner, J. Beckmann, T. Serikawa, F. Soubrier, C. Dubay, P. Cartwright, DeGouyon, B., C. Julier, S. Takahasi, M. Vincent, M. Georges, G. Lathrop: Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. In: Nature . No. 353, 1991, pp. 521-529.
  • with HJ Jacob, K. Lindpaintner, SE Lincoln, K. Kusumi, RK Bunker, YP Mao, VJ Dzau , ES Lander : Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. In: Cell . No. 67, 1991, pp. 213-224, PMID 1655275 .
  • with J. Wagner, K. Zeh, M. Bader, JB Michel, M. Paul, F. Zimmermann, P. Ruf, U. Hilgenfeldt, U. Ganten: Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. In: Proc. Natl. Acad. Sci. USA . No. 89, 1992, pp. 7806-7810, PMID 1502199 .
  • with S. Rubattu, M. Volpe, R. Kreutz, U. Ganten, K. Lindpaintner: Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease . In: Nature Genetics , No. 13, 1996, pp. 429-434, PMID 8696337 .
  • with F. Fändrich, X. Lin, GX Chai, M. Schulze, M. Bader, J. Holle, DS Huang, R. Parvaresch, N. Zavazava, B. Binas: Preimplantation-stage stem cells induce allogeneic graft tolerance without supplementary host conditioning. In: Nature Medicine . No. 8, 2002, pp. 171-178, PMID 11821902 .
  • Council Genome Sequencing Project Consortium. Genome Sequence of the Brown Norway rat yields insights into mammalian evolution. In: Nature. No. 428, 2004, pp. 493-521.
  • M. Bader, D. Ganten: Update on tissue renin-angiotensin systems. In: J Mol Med . No. 86, 2008, pp. 615-621.
  • Ganten, D. Chair of the working group: Public Health in Germany - Structures, Developments and Global Challenges - Statement by the National Academy of Sciences Leopoldina, acatech - German Academy of Science and Engineering - and the Union of the German Academy of Sciences , June 2015, ISBN 978 -3-8047-3345-9 .
  • K. Sipido, L. Degos, R. Frackowiak, D. Ganten, H. Hofstraat, I. Horvath, F. Luyten, M. Manns, W. Oertel, T. Zima: Better research for better health in Europe: The " Scientific Panel for Health “Vision . In: The Lancet. No. 388, 2016, pp. 865–866.
  • Ganten, D. "Franz Gross, Pharmacologist and Hypertensive Researcher." Naunyn-Schmiedebergs Archives of Pharmacology 390 : 1, 2017.
  • Lissek, T., M. Adams, J. Adelman, E. Ahissar, M. Akaaboune, H. Akil, M. a'Absi, F. Arain, J. Carlos Arango-Lasprilla, D. Atasoy, J. Avila, A. Badawi, H. Bading, AM Baig, J. Baleriola, C. Belmonte, I. Bertocchi, H. Betz, C. Blakemore, O. Blanke, P. Boehm-Sturm, T. Bonhoeffer, P. Bonifazi, N Brose, P. Campolongo, T. Celikel, CC Chang, T.-Y. Chang, A. Citri, HT Cline, JM Cortes, K. Cullen, K. Dean, JM Delgado-Garcia, M. Desroches, JF Disterhoft, JE Dowling, A. Draguhn, SF El-Khamisy, A. El Manira, SA Enam, JM Encinas, A. Erramuzpe, JA Esteban, I. Farinas, E. Fischer, I. Fukunaga, I. Gabilondo, D. Ganten, A. Gidon, J. Carlos Gomez-Esteban, P. Greengard, V. Grinevich , A. Gruart, R. Guillemin, AR Hariri, B. Hassan, M. Hausser, Y. Hayashi, NK Hussain, AA Jabbar, M. Jaber, R. Jahn, EM Janahi, M. Kabbaj, H. Kettenmann, M Kindt, S. Knafo, G. Koehr, S. Komai, H. Krugers, B. Kuhn, N. Lakhdar Ghazal, ME Larkum, M. London, B. Lutz, C. Matute, L. Martinez-Millan, M. Maroun, J. McGaugh, AA Moustafa, A. Nasim, K.-A. Nave, E. Neher, K. Nikolich, T. Outeiro, LM Palmer, O. Penagarikano, I. Perez-Otano, DW Pfaff, B. Poucet, A.-u. Rahman, P. Ramos-Cabrer, A. Rashidy-Pour, RJ Roberts, S. Rodrigues, JR Sanes, AT Schaefer, M. Segal, I. Segev, S. Shafqat, NA Siddiqui, H. Soreq, E. Soriano- Garcia, R. Spanagel, R. Sprengel, G. Stuart, TC Sudhof, J. Tonnesen, M. Trevino, BM Uthman, JC Venter, A. Verkhratsky, C. Weiss, TN Wiesel, E. Yaksi, O. Yizhar, LJ Young, P. Young, NH Zawia, JL Zugaza and MT Hasan. "Building Bridges through Science." Neuron 96 (4): 6, 2017.
  • Hachinski, V., D. Ganten, D. Lackland, R. Kreutz, K. Tsioufis and W. Hacke. "Implementing the Proclamation of Stroke and Potentially Preventable Dementias." International Journal of Stroke 13 (8): 7, 2018.
  • Jochen Niehaus, Detlev Ganten. "Health and Critical Illness from a Global Perspective". Nova Acta Leopoldina, NF No. 421, 2018.
  • Detlev Ganten, Karsten Lunze, Nora Anton, Ilona Kickbusch. "Health is more than medicine". G20 Insights, May 30, 2018.
  • Detlev Ganten *, João Gabriel Silva, Fernando Regateiro, Ali Jafarian, Hélène Boisjoly, Antoine Flahaut, Ben Canny, José Otávio Auler Jr, Julian Kickbusch, Joerg Heldmann, Axel Pries and Michael J. Klag. “Science has to take responsibility 10 years World Health Summit - The road to better health for all”. Frontiers in public health, 14 October 2018, doi: 10.3389 / fpubh.2018.00314.
  • Reinhold Kreutz, Engi Abd El-Hady Algharably, Detlev Ganten, Franz Messerli. "Renin Angiotensin System (RAS) and COVID-19". Thieme Verlag, doi http://dx.doi.org/10.1055/a-1152-3469, 2020.

Books (selection)

  • with Klaus Ruckpaul (Hrsg.): Handbook of molecular medicine . Eight volumes. Springer, Berlin / Heidelberg 1997-2000, DNB 949377112 .
  • with Klaus Ruckpaul (ed.): Fundamentals of molecular medicine . Springer, Berlin / Heidelberg 2003. 2nd revised and expanded edition. Springer, Berlin / Heidelberg / New York 2003 (formerly part of the handbook of molecular medicine ).
  • with Thomas Deichmann and Thilo Spahl: Life, nature, science: everything you need to know . Eichborn, Frankfurt am Main 2003, ISBN 3-8218-3981-3 (as paperback edition: Natural science: everything you need to know . Dtv, Munich 2005, ISBN 3-423-34237-4 ).
  • with Klaus Ruckpaul: Encyclopedic reference of genomics and proteomics in molecular medicine . Springer, 2006, ISBN 978-3-540-44244-8 .
  • with Volker Gerhardt, Nida Rümelin: What is man? In: Human project - an interdisciplinary anthropology, de Gruyter, 2008
  • with Thilo Spahl and Thomas Deichmann : The Stone Age is in our bones: Health as a legacy of evolution . Piper, Munich / Zurich 2011, ISBN 978-3-492-26398-6 (first 2009).
  • with Jochen Niehaus: The health formula: Understanding and preventing the major diseases of civilization. Knaus, Munich 2014, ISBN 978-3-8135-0648-8
  • with Kristina Heldmann. “No ice bear without ice”, Jacoby & Stuart publishing house, 2020, ISBN 978-3-96428-055-8 .

Web links

Individual evidence

  1. ↑ Prof. Karl Max Einhäupl at the head of the Charité, Senator pays tribute to Prof. Detlev Ganten's services. ( Memento of February 11, 2009 in the Internet Archive ) June 6, 2008, accessed on May 16, 2019.
  2. ↑ Detlev Ganten: Our body is the result of evolution. ( Memento from May 12, 2011 on WebCite ) In: ARD - TV show: The Stone Age Recipe. May 11, 2011.
  3. ↑ Information from the Federal President's Office.
  4. ^ Members of the National Ethics Council. ( Memento from November 20, 2008 in the Internet Archive ) In: www.ethikrat.org. Retrieved November 11, 2008.
personal data
SURNAME Ganten, Detlev
BRIEF DESCRIPTION German specialist in pharmacology and molecular medicine
DATE OF BIRTH March 28, 1941
PLACE OF BIRTH Luneburg