Proamanullin: Difference between revisions
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Revision as of 19:49, 8 August 2011
File:Proamanullin 3d chemical structure.png | |
Names | |
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Other names
2-L-Proline-3-isoleucine-alpha-amanitin
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Identifiers | |
3D model (JSmol)
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PubChem CID
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Properties | |
C39H54N10O11S | |
Molar mass | 870.97 g/mol |
Appearance | Colorless, odorless |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms.
Toxicology
Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]
References
- ^ Cochet-Meilhac M, Chambon P (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. PMID 4601749.
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