John F. Hartwig

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John F. Hartwig, 2007

John Frederick Hartwig (born August 7, 1964 in Elmhurst , Illinois ) is an American chemist .

Live and act

John F. Hartwig was born near Chicago and grew up in upstate New York . He studied chemistry from 1982 to 1986 at Princeton University , where he obtained a Bachelor of Arts in 1986 . Maitland Jones supervised his bachelor thesis . In 1990 Hartwig received his Ph.D. in chemistry from the University of California, Berkeley. PhD . In his doctoral thesis he dealt with the synthesis and the reaction mechanisms of complexes with ruthenium- carbon, ruthenium-nitrogen and ruthenium-oxygen bonds. His supervisors were Richard A. Anderson and Robert Bergman . As a postdoctoral fellow at the American Cancer Society , he was with Stephen Lippard at the Massachusetts Institute of Technology from 1990 to 1992 . There he investigated platinum - DNA adducts that are formed after taking platinum-containing chemotherapeutic agents and their ability to inhibit the replication of DNA and to bind proteins . In 1992 he moved to Yale University , where he was Assistant Professor (1992–1996), Associate Professor (1996–1998), Professor (1998–2004) and finally Irénée P. duPont Professor of Chemistry (2004–2006). From 2006 to 2011 he was Kenneth L. Rinehart Jr. Professor of Chemistry at the University of Illinois at Urbana-Champaign and since 2011 he has been the Henry Rapoport Professor of Chemistry at the University of California, Berkeley and a scientist at the Lawrence Berkeley National Laboratory .

Hartwig works in the field of organometallic chemistry and complex chemistry . He explores new reactions of organic compounds that are catalyzed by complexes of transition metals . For example, he developed a palladium- catalyzed amination , which is now known as the Buchwald-Hartwig coupling , a method for the preparation of aryl amines and aryl ethers from aryl halides or aryl sulfonates , a selective catalytic functionalization of alkanes and many other palladium-catalyzed reactions.

Awards

Memberships

Works

Hartwig published more than 300 papers in scientific journals, more than 10 patents and the following monographs:

  • John F. Hartwig: Synthesis and reactivity of compounds containing ruthenium-carbon, -nitrogen, and -oxygen bonds. Thesis (Ph.D.), University of California, Berkeley, 1990
  • John F. Hartwig: Organotransition Metal Chemistry. From bonding to catalysis. University Science Books, Mill Valley, California 2010, ISBN 1-891389-53-X , ISBN 978-1-891389-53-5 (revision of the textbook by James P. Collman et al .: Principles and Applications of Organotransition Metal Chemistry. University Science Books, Mill Valley, California 1980, ISBN 0-935702-03-2 , ISBN 0-19-855703-5 ; 2nd edition 1987)

Web links

Commons : John F. Hartwig  - Collection of pictures, videos and audio files

Individual evidence

  1. ^ John F. Hartwig, Maitland Jones Jr., Robert A. Moss and Witold Ławrynowicz: A Photochemical Source of Dibromo- and Dichlorocarbene. A Cautionary Tale Regarding the Stereochemistry of Dibromocarbene Addition Reactions. In: Tetrahedron Letters . Volume 27, No. 49, 1986, pp. 5907-5910, doi: 10.1016 / S0040-4039 (00) 85359-9
  2. ↑ Life data, publications and academic family tree of John F. Hartwig at academictree.org, accessed on February 8, 2018.
  3. ↑ John F. Hartwig and Stephen J. Lippard: DNA Binding Properties of cis- [Pt (NH 3 ) (C 6 H 11 NH 2 ) Cl 2 ], a Metabolite of an Orally Active Platinum Anticancer Drug. In: Journal of the American Chemical Society . Volume 114, No. 14, 1992, pp. 5646-5654, doi: 10.1021 / ja00040a026 ; John F. Hartwig, Pieter M. Pil and Stephen J. Lippard: Synthesis and DNA-Binding Properties of a Cisplatin Analogue Containing a Tethered Dansyl Group. In: Journal of the American Chemical Society. Volume 114, No. 21, 1992, pp. 8292-8293, doi: /10.1021/ja00047a051
  4. ↑ Original articles: Frederic Paul, Joe Patt and John F. Hartwig: Palladium-Catalyzed Formation of Carbon-Nitrogen Bonds. Reaction Intermediates and Catalyst Improvements in the Hetero Cross-Coupling of Aryl Halides and Tin Amides. In: Journal of the American Chemical Society. Volume 116, No. 13, 1994, pp. 5969-5970, doi: 10.1021 / ja00092a058 ; Anil S. Guram and Stephen L. Buchwald: Palladium-Catalyzed Aromatic Aminations with in situ Generated Aminostannanes. In: Journal of the American Chemical Society. Volume 116, No. 17, 1994, pp. 7901-7902, doi: 10.1021 / ja00096a059
  5. ↑ John F. Hartwig: Transition Metal-Catalyzed Synthesis of Arylamines and Aryl Ethers from Aryl Halides and Triflates: Applications and Reaction Mechanism. In: Angewandte Chemie . Volume 110, No. 15, August 3, 1998, pp. 2154-2177, doi : 10.1002 / (SICI) 1521-3757 (19980803) 110: 15 <2154 :: AID-ANGE2154> 3.0.CO; 2-C ; English as: John F. Hartwig: Transition Metal Catalyzed Synthesis of Arylamines and Aryl Ethers from Aryl Halides and Triflates: Scope and Mechanism. In: Angewandte Chemie International Edition. Volume 37, No. 15, August 17, 1998, pp. 2046-2067, doi : 10.1002 / (SICI) 1521-3773 (19980817) 37:15 <2046 :: AID-ANIE2046> 3.0.CO; 2-L
  6. Jump up ↑ Huiyuan Chen, Sabine Schlecht, Thomas C. Semple and John F. Hartwig: Thermal, Catalytic, Regiospecific Functionalization of Alkanes. In: Science . Volume 287, No. 5460, March 17, 2000, pp. 1995-1997, doi: 10.1126 / science.287.5460.1995
  7. ↑ Janis Louie and John F. Hartwig: Palladium-Catalyzed Synthesis of Arylamines from Aryl Halides. Mechanistic Studies Lead to Coupling in the Absence of Tin Reagents. In: Tetrahedron Letters. Volume 36, No. 21, May 22, 1995, pp. 3609-3612, doi: 10.1016 / 0040-4039 (95) 00605-C ; Michael S. Driver and John F. Hartwig: A Second-Generation Catalyst for Aryl Halide Amination: Mixed Secondary Amines from Aryl Halides and Primary Amines Catalyzed by (DPPF) PdCl 2 . In: Journal of the American Chemical Society. Volume 118, No. 30, 1996, pp. 7217-7218, doi: 10.1021 / ja960937t ; John F. Hartwig: Carbon-Heteroatom Bond-Forming Reductive Eliminations of Amines, Ethers, and Sulfides. In: Accounts of Chemical Research . Volume 31, No. 12, 1998, pp. 852-860, doi: 10.1021 / ar970282g ; John F. Hartwig, Motoi Kawatsura, Sheila I. Hauck, Kevin H. Shaughnessy and Luis M. Alcazar-Roman: Room-Temperature Palladium-Catalyzed Amination of Aryl Bromides and Chlorides and Extended Scope of Aromatic C − N Bond Formation with a Commercial Ligand. In: The Journal of Organic Chemistry . Volume 64, No. 15, 1999, pp. 5575-5580, doi: 10.1021 / jo990408i ; Noriyasu Kataoka, Quinetta Shelby, James P. Stambuli and John F. Hartwig: Air Stable, Sterically Hindered Ferrocenyl Dialkylphosphines for Palladium-Catalyzed C − C, C − N, and C − O Bond-Forming Cross-Couplings. In: The Journal of Organic Chemistry. Volume 67, No. 16, 2002, pp. 5553-5566, doi: 10.1021 / jo025732j
  8. ↑ Wolf Prize 2019
personal data
SURNAME Hartwig, John F.
ALTERNATIVE NAMES Hartwig, John Frederick (full name); Hartwig, John
BRIEF DESCRIPTION American chemist
DATE OF BIRTH 7th August 1964
PLACE OF BIRTH Elmhurst , Illinois