Lozano played for the University of Southern California from 1983 to 1985 and became a professional tennis player in 1986. That same year, he stood at the side of Todd Witsken , his partner from college days , in the quarterfinals of Indianapolis . In 1987 he reached his first double-final on the ATP World Tour with Diego Pérez in Itaparica . The following year he was able to win four tournaments with Todd Witsken, two more followed in 1989. After two defeats in the final in 1990 Lozano and Witsken parted ways, Lozano then won three more tournaments with other doubles partners. In total, he was able to win nine titles in the double competition, six of them with his long-term partner Witsken. Another 13 times he was in a double-final. He reached his highest score in the tennis world rankings in 1988 with position 51 in singles and fourth in doubles.
His best individual result in a Grand Slam tournament was reaching the round of 16 of the US Open in 1988. In the same year he was there at the side of Todd Witsken in the semi-finals of the doubles competition. Both also reached the quarter-finals of the French Open that year . In 1988 he won the mixed competition at the French Open alongside Lori McNeil . In 1990 he repeated this triumph with Arantxa Sánchez Vicario .
Lozano played 19 singles and 24 doubles games for the Mexican Davis Cup team between 1982 and 1995 . When he first appeared in 1981, his opponent in the first-round encounter of the world group was USA . Although he won the doubles on the side of Raúl Ramírez , but lost in both singles against John McEnroe and Roscoe Tanner . In 1986 he was used in the quarter-finals against the USA in doubles, with Fernando Pérez Pascal he was defeated by the world-class doubles Ken Flach and Robert Seguso in four sets.
Lozano has been the team principal of the Mexican Davis Cup team since 2009.