Michael Berridge

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Sir Michael John Berridge (born October 22, 1938 in Kadoma , Rhodesia - † February 13, 2020 ) was a British biologist and a pioneer in the field of cellular communication . In blowflies he examined the secretion of saliva and discovered the intracellular messenger substance inositol trisphosphate (also inositol 1,4,5-trisphosphate , IP 3 for short ), which can cause a cell to release calcium as a result of external stimuli . This improved understanding of how external stimuli can trigger a response inside cells. Subsequently, IP 3 proved to be a universal messenger substance in eukaryotes . a. plays a role in connection with gene transcription , the regulation of metabolism , fertilization and cell death .

Life

After attending Jameson High School in Kadoma, Berridge studied zoology and chemistry at the University College of Rhodesia and Nyasaland and from 1961 as a doctoral student with Vincent Wigglesworth at the University of Cambridge . After completing his doctorate on the function of the Malpighian vessels in fire bugs , he moved to the United States to the University of Virginia and later to Case Western Reserve University , where he chose blowflies instead of fire bugs as model organisms for his hormone research. In 1969 he went back to Great Britain to the University of Cambridge, where he developed his groundbreaking insights into the role of IP 3 in metabolism.

Honors

Michael Berridge won a Gairdner Foundation International Award in 1988 , the Albert Lasker Award for Basic Medical Research in 1989 , the Wolf Prize in Medicine in 1994/95 , the Massry Prize in 1996 , and the Ernst Schering Prize in 1999 for his pioneering work in the field of calcium - Signal transduction and the 2005 Shaw Prize .

He was a member of the Royal Society and a professor at the Babraham Institute, Cambridge. From 1989 he was a member of the Academia Europaea . On February 18, 1998 he was knighted as a Knight Bachelor ("Sir"). In 1999 he was elected to the American Academy of Arts and Sciences and the National Academy of Sciences . From 2007 he was an elected member of the American Philosophical Society .

literature

Web links

Individual evidence

  1. ↑ In tribute: Sir Michael Berridge FRS. Obituary on the Babraham Institute website on February 13, 2020.
  2. ↑ Martin Bootman, Antony galleon and Colin Taylor: Professor Sir Michael Berridge FRS (1938-2020). In: Current Biology . Volume 30, No. 9, PR374-R376, 2020, doi: 10.1016 / j.cub.2020.03.044 .
  3. ↑ Robert H. Michell: Inositol phospholipids and cell surface receptor function. In: Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes. Volume 415, No. 1, 1975, pp. 81-147, doi: 10.1016 / 0304-4157 (75) 90017-9 .
  4. ^ H. Streb, RF Irvine, MJ Berridge and I. Schulz: Release of Ca2 + from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. In: Nature . Volume 306, 1983, pp. 67-69, doi: 10.1038 / 306067a0 .
  5. ^ Membership directory: Michael Berridge. Academia Europaea, accessed October 27, 2017 .
  6. ↑ Knights and Dames: BED-BUG at Leigh Rayment's Peerage
  7. ↑ Member History: Michael J. Berridge. American Philosophical Society, accessed May 1, 2018 (English, with a short biography).
personal data
SURNAME Berridge, Michael
ALTERNATIVE NAMES Berridge, Michael John (full name)
BRIEF DESCRIPTION British biologist
DATE OF BIRTH October 22, 1938
PLACE OF BIRTH Kadoma , Zimbabwe
DATE OF DEATH February 13, 2020