Exceptional situation
| Movie | |
|---|---|
| German title | Exceptional situation |
| Original title | Extraordinary Measures |
| Country of production | United States |
| original language | English |
| Publishing year | 2010 |
| length | 106 minutes |
| Age rating | FSK o.A. |
| Rod | |
| Director | Tom Vaughan |
| script | Robert Nelson Jacobs |
| production |
Michael Shamberg Stacey Sher Carla Santos Harrison Ford |
| music | Andrea Guerra |
| camera | Andrew Dunn |
| cut | Anne V. Coates |
| occupation | |
| |
Exceptional Situation is an American drama film , starring Brendan Fraser and Harrison Ford , from 2010. Based on a true story and the novel The Cure by Greeta Anand , the film tells the story of John Francis Crowley as he did his job gives up, founds a bio-tech company in order to be able to treat two of his children with the incurable disease Pompe disease .
action
John Francis Crowley's two youngest children , Megan and Patrick, suffer from the incurable disease Pompe disease . The life expectancy of children with this disease is no more than nine years, which is why it hits John all the harder that after her eighth birthday Megan is hospitalized with a cold and barely escapes death. It blows the fuses on John so much that during a professional conference he leads, he just leaves the room and goes to Nebraska to see Dr. Seeking Robert Stonehill. This has put forward the most promising theory to date for the treatment of Pompe disease. The only thing is that his university, the University of Nebraska-Lincoln , does not grant him the research funding he needs to test his theory in practice. For the first research alone, Stonehill would need at least $ 500,000.
John promises Stonehill to get the money with the help of his foundation and also manages to raise almost 100,000 US dollars within a month. Since Stonehill believes that research alone would cost more money, he suggests that John start his own biotechnology company, which he can run as CEO . John then leaves his well-paid and insured job and takes the professional risk to save his children. But when he is looking for powerful donors, it turns out that Stonehill tends to have eccentric outbursts and that he cannot succeed in some good business in this way. In doing so, John repeatedly has to make unpleasant decisions that Stonehill displeases in order not to endanger the joint project.
After John was able to raise 10 million US dollars, the research seems to be financially secure and to lead to initial results. But after a few months, investors are impatient and want the company to handle , which is why John is again before deciding how to ensure the continuation of the project. Against Stonehill's will, John decides to sell her biotechnology company to a pharmaceutical company for a profit . It conducts research in the same area, secures funding and, thanks to the Orphan Medicines Act , improves the development requirements. John is hardly accepted by the new management as a non-scientist. The team of Dr. Stonehill will be incorporated into the pharmaceutical company and is one of four that are researching an enzyme for patients with Pompe disease in parallel but independently of one another. But research is always hindered, especially by the difficult character of Stonehill, which becomes a challenge for John. When the time for his children threatens to run out because their health is deteriorating, John enforces that the four teams no longer conduct research in competition with one another, but that a joint management team is formed, from which, however, Dr. Stonehill remains excluded. This leads to a break between the former partners.
When the decisive enzyme for treatment is finally found and the clinical studies can be initiated, John gets a shock. The pharmaceutical company is only setting up an infant study, since smaller amounts of the enzyme to be synthesized are required for infants. However, this infant study would result in his children not receiving the drugs they were hoping for. John then tries to steal the drugs he needs and is caught by the company's security service. Stonehill helps him out of the situation by claiming to have sent John to the medicine cabinet with his own security card to get him medicine for his test series. Stonehill also mentions a better way to help John's children. With the help of a registered sibling study , his children are also treated with the new agent. When the pharmaceutical company notices these machinations of the two, the board of directors is forced to fire John in order to avoid any conflict of interest. John packs his things and can watch his two children receive the life-saving medication. Dr. Stonehill then also leaves the company and uses the proceeds from the company sale to found his own company.
background
The drug Myozyme (active ingredient alglucosidase alfa ) for the treatment of Pompe disease was approved simultaneously by the EU Commission and the American Food and Drug Administration in spring 2006 , so that since then over 1000 newborns have been treated and have not died in the first year of life.
The start-up company Priozyme , which appears in the film, is based on the real company Novyzyme , which was founded by Crowley. Even the larger pharmaceutical companies Zymagen has a real role model, namely in Cambridge -based Genzyme . The company itself commented on the film and the truth of the story on its website.
The film character Dr. Robert Stonehill is based on both Crowley's years of experience with various scientists and the real researcher William Canfield. John Francis Crowley is in a cameo as a financial investor at the side of Dr. To see Renzler.
production
Exceptional Situation was filmed in Portland , Alameda , Vancouver , Estacada , Lake Oswego , Manzanita , Beaverton , St. Paul , Tualatin as well as in Oak Park and Laurelhurst Park . Filming began on April 6, 2009. The budget of the film is approximately 31 million US dollars estimated.
Publication and grossing
The film came on 22 January 2010 in the Canadian and US -amerikanischen cinemas and was on its opening weekend in the US only 6 million US dollars to import its production costs in the amount of 31 million US dollars in 2549 cinemas again. This meant that he had to give himself up on parole for the newly launched films Legion and Tooth Fairy and only came in at number 8 on the cinema charts. Overall, the film grossed only $ 15 million worldwide, which is less than half of its budget and can therefore be viewed as a flop. The film was shown in Switzerland from March 10, 2010. The film celebrated its German theatrical release on March 11, 2010 and the DVD release by Concorde Video with an FSK-0 approval on August 5, 2010.
German dubbed version
The German dubbing was done at Film- & Fernseh-Synchron in Munich . The dubbing direction was carried out by Cay-Michael Wolf .
| actor | German speaker | role |
|---|---|---|
| Brendan Fraser | Torsten Münchow | John Crowley |
| Harrison Ford | Wolfgang Pampel | Dr. Robert Stonehill |
| Keri Russell | Solveig Duda | Aileen Crowley |
| Patrick Bauchau | Osman Ragheb | CEO Erich Loring |
| Jared Harris | Tobias Lelle | Dr. Kent Webber |
| PJ Byrne | Patrick Schröder | Dr. Preston |
| Lily Mariye | Dagmar Dempe | Dr. Waldman |
| Courtney B. Vance | Ole Pfennig | Marcus Temple |
| Alan jerk | Claus-Peter Damitz | Pete Sutphen |
criticism
The film received some devastating reviews. The Rotten Tomatoes website counted 36 positive reviews of 134 professional reviews, which corresponds to a value of 27%. However, the film was received with mixed reactions from the general public, because at the same time 55% of 72,477 users rated the film positively. This, in turn, is generally confirmed by the online film archive IMDb , another platform on which audience votes can submit their film reviews, because there 6,647 users gave the film an average of 6.3 out of 10 possible points. (As of October 12, 2011)
However, the film received scientific praise. The doctor Ramona Bates wrote in the EmaxHealth that it was good that the film brought attention to Pompe disease. Peter Rainer from the Christian Science Monitor thought it was good that the film shows the struggle of pharmaceutical companies and their funding, which is necessary to develop drugs for a rare disease. Jef Akst also wrote in The Scientist that the film portrayed the problems of funding drug research well.
“The script by Robert Nelson Jacobs ( Chocolat ) takes liberties, reduces the father's long-term struggle to about a year [...] and also uses conventional Hollywood dramaturgy to create tension. In fact, the effectiveness of the drug that was finally developed is controversial, but all objections ultimately fizzle out because the film works emotionally. "
“Exception [situation] is well meant and conveys a hopeful message. Visually and stylistically, however, the film lags behind Lorenzo's oil . The pathos is applied quite thickly: the sun illuminates the bright halls of the pharmaceutical company, while the Crowleys and affected families appeal to managers and scientists "
"The drama focuses more on the emotional aspects than on the unmasking of the mechanisms of the pharmaceutical industry, with emotion and pathos being applied too thickly, so that the story based on a true occurrence seems implausible."
Awards
The Political Film Society nominated the film for the 2010 Political Film Society Award for Exposé .
literature
- Greeta Anand: The Cure , Harper Paperbacks 2009, ISBN 9780060734398
Web links
- Exceptional situation in the Internet Movie Database (English)
- Exceptional situation in the German dubbing index
- Official English website
Individual evidence
- ↑ FAQ ( Memento of the original from February 22, 2013 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. at genzyme.com , accessed September 18, 2012
- ↑ Internet Movie Database : Background information
- ↑ Internet Movie Database : Filming Locations
- ↑ a b Internet Movie Database : Budget and Box office income
- ↑ Exceptional situation on boxofficemojo.com , accessed on July 16, 2011
- ↑ January 22-24, 2010 on boxofficemojo.com , accessed July 16, 2011
- ↑ Internet Movie Database : Start Dates
- ↑ a b c exceptional situation. In: synchronkartei.de. German synchronous index , accessed on August 11, 2013 .
- ↑ exceptional situation . rottentomatoes.com, accessed October 12, 2011 .
- ↑ EmaxHealth: "Extraordinary Measures" Brings Attention Pompe Disease . Retrieved July 22, 2010.
- ^ Peter Rainer: Extraordinary Measures Movie Review . January 22, 2010. Retrieved July 22, 2010.
- ^ A review of Extraordinary Measures . Retrieved July 22, 2010.
- ↑ exceptional situation . In: Lexicon of International Films . Film service , accessed March 2, 2017 .
