Jeesewitz was first mentioned in a document in 1350 as "Gesewicz, Jesewicz". Further mentions were:
1791: Jehsewitz, or Jeesewitz; Jesewitz
On January 1, 1952, Jeesewitz was incorporated into Prösitz, and on January 1, 1993, Prösitz was again incorporated into Mutzschen. With the incorporation of Mutzschen into Grimma on January 1, 2012, Jeesewitz has been part of the latter's municipality since then.