Johannes Fibiger
Johannes Andreas Grib Fibiger | |
|---|---|
 Fibiger won a Nobel Prize in 1926 | |
| Born | April 23, 1867 |
| Died | January 30, 1928 |
| Nationality | Danish |
| Known for | cancer |
| Awards | 1926 Nobel Prize in Physiology or Medicine |
Johannes Andreas Grib Fibiger (April 23, 1867 Silkeborg - January 30, 1928 Copenhagen) was a Danish scientist who won the 1926 Nobel Prize in Physiology or Medicine. Fibiger had claimed to find an organism he called Spiroptera carcinoma that caused cancer in mice and rats. Later, it was shown that this specific organism was not the primary cause of the tumors. Because of this, some consider Fibiger's Nobel Prize to be undeserved, but others credit Fibiger with showing that external stimuli can induce cancer.
Research
While studying tuberculosis in lab rats, Fibiger found tumors in some of his rats. He discovered that these tumors were associated with parasitic nematode worms that had been living in some cockroaches that the rats had eaten. He thought that these organisms may have been the cause of the cancer. In fact, the rats had been suffering from a vitamin A deficency and this was the main cause of the tumors. The parasites had merely caused the tissue irritation that drove the damaged cells into cancer; any tissue irritation could have induced the tumors. Although the specific link between the parasites and cancer was later known to be relatively unimportant, the idea that tissue damage was a cause of cancer was still an important advance in cancer research.
One of his experiments from 1998 is by some regarded as the first controlled clinical trial.[1]
Biography
Fibiger became a medical doctor in 1890 and studied under Robert Koch and Emil Adolf von Behring in Berlin. He received his research doctorate from the University of Copenhagen in 1895 and became a professor there.
References
- ^ A. Hrobjartsson, P. C. Gotzsche & C. Gluud (1998). "The controlled clinical trial turns 100 years: Fibiger's trial of serum treatment of diphtheria". BMJ. 317 (7167): 1243–1245. PMID 9794873.
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Further reading
- Nobel Lectures, Physiology or Medicine 1922-1941, Elsevier Publishing Company, Amsterdam, 1965.
- Modlin, I M; Kidd, M; Hinoue, T (2001), "Of Fibiger and fables: a cautionary tale of cockroaches and Helicobacter pylori.", J. Clin. Gastroenterol., vol. 33, no. 3 (published 2001 Sep), pp. 177–9, PMID:11500602
{{citation}}: Check date values in:|publication-date=(help) - Gluud, C N (1998), "[Centenary of Fibiger's controlled clinical trial]", Ugeskr. Laeg., vol. 160, no. 51 (published 1998 Dec 14), pp. 7407–8, PMID:9889652
{{citation}}: Check date values in:|publication-date=(help) - Raju, T N (1998), "The Nobel chronicles. 1926: Johannes Andreas Grib Fibiger (1867-1928).", Lancet, vol. 352, no. 9140 (published 1998 Nov 14), p. 1635, PMID:9843145
{{citation}}: Check date values in:|publication-date=(help) - Stolley, P D; Lasky, T (1992), "Johannes Fibiger and his Nobel Prize for the hypothesis that a worm causes stomach cancer.", Ann. Intern. Med., vol. 116, no. 9 (published 1992 May 1), pp. 765–9, PMID:1558350
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