Philippa Marrack

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Philippa Marrack, 1992

Philippa Charlotte Marrack (born June 28, 1945 in Ewell , Surrey , England) is a British-American biochemist and immunologist . She is a professor at the University of Colorado in Denver , Colorado .

Life

Philippa Marrack graduated from the University of Cambridge with a bachelor's and master's degree in biochemistry and a Ph.D. in biology ( "Biological sciences" , 1970). She worked as a postdoctoral fellow at the MRC Laboratory for Molecular Biology in Cambridge from 1970/1971 and from 1971 to 1973 with Richard Dutton at the University of California, San Diego in La Jolla , California .

In 1974 she took a position as a research assistant in the Department of Microbiology at the University of Rochester in Rochester , New York . There she received her first junior professorship ( Assistant Professor 1975, Associate Professor 1979). From 1976 she researched for the American Heart Association , from 1979 - partly in a leading position - for the National Jewish Health , a leading institution for immunological and allergological research based in Denver , Colorado .

In 1980, Marrack became an Associate Professor in the Department of Biophysics , Biochemistry, and Genetics at the University of Colorado at Denver. Five years later, she was given a full professorship, which she still holds today (as of 2011).

Philippa Marrack is a niece of immunologist John Marrack . Her first marriage was to the biochemist Tony Hunter . She has published numerous works with her future husband, John W. Kappler .

Act

Philippa Marrack, together with her husband, the immunologist John W. Kappler , contributed important knowledge about the molecular basis of the recognition of antigens by T cells . Among other things, they were able to show that the T cell receptor consists of two subunits and recognizes both MHC molecules and antigens. They also described the T cell receptor and the time frame in which its gene rearrangement takes place, and were able to identify the elimination of T cell clones as the central mechanism of self-tolerance . These findings are fundamental to understanding autoimmune diseases , allergies , transplant rejection, and vaccinations . In addition, Marrack discovered the superantigens that can trigger particularly violent reactions in the immune system.

Marrack is represented on the scientific advisory boards of numerous professional societies and journals . She served as President of the American Association of Immunologists in 2000/2001 . Since 2019 she has been one of the favorites for a Nobel Prize ( Clarivate Citation Laureates ) by the media group Clarivate .

Awards (selection)

Web links

Individual evidence

  1. ^ The American Association of Immunologists: AAI Past Presidents and Officers ; accessed on May 7, 2019.
  2. ^ Royal Society GlaxoSmithKline Prize and Lecture at the Royal Society (royalsociety.org); Retrieved July 22, 2013
  3. ↑ Book of Members 1780 – present, Chapter M. (PDF; 1.1 MB) In: American Academy of Arts and Sciences (amacad.org). Retrieved May 7, 2019 .
  4. ^ Goethe University - laureate since 1952. In: uni-frankfurt.de. March 14, 2016, accessed January 23, 2016 .
  5. ^ William B. Coley Award. In: cancerresearch.org. Retrieved January 24, 2016 .
  6. ^ Two Immunologists Win the Horwitz Prize at columbia.edu; Retrieved January 4, 2011
  7. ↑ Previous winners at dicksonprize.pitt.edu; Retrieved January 4, 2011
  8. ↑ Fellows at royalsociety.org; Retrieved January 4, 2011
  9. ^ L'Oréal UNESCO Prize: "For Women in Science" at unesco.de; Retrieved January 4, 2011
  10. ^ Winner of the Avery Landsteiner Prize at the German Society for Immunology (dgfi.org); accessed on May 7, 2019.
personal data
SURNAME Marrack, Philippa
ALTERNATIVE NAMES Marrack, Philippa Charlotte (full name); Hunter, Philippa
BRIEF DESCRIPTION British-American biochemist and immunologist
DATE OF BIRTH June 28, 1945
PLACE OF BIRTH Ewell , Surrey , England