Bruce Beutler

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Bruce Beutler at the Nobel Prize Press Conference 2011

Bruce Alan Beutler (born December 29, 1957 in Chicago ) is an American immunologist and geneticist who has carried out decisive research work in the field of immunology , particularly the toll-like receptors , and who was awarded the Nobel Prize in Physiology or Medicine in 2011 for his achievements .

Life

Beutler was born in Chicago in 1957 as the son of the German emigrant Ernest Beutler . The family then lived in California. Bruce Beutler studied biology at the University of California, San Diego until 1976, followed by a medical degree at the University of Chicago . In 1981 he received his MD. From 1985 to 1986 Beutler was an assistant professor at Rockefeller University . He then held various positions at the University of Texas Southwestern Medical Center at Dallas and at the Howard Hughes Medical Institute until 2000 . From 2000 to 2007, Beutler was a professor in the Department of Immunology at the Scripps Research Institute in La Jolla , California . Since 2007 he has headed the genetics department of the Scripps Research Institute. Since September 2011, Beutler has also been Director of the Center for the Genetics of Host Defense at the University of Texas Southwestern Medical Center.

He is the father of three sons.

Act

Since the early 1980s, Beutler initially researched tumor necrosis factor (TNF) and the reaction of the immune system to endotoxins from bacteria (which belong to the LPS ), eventually identifying the long-sought endotoxin receptor (TLR 4), which is one of the Toll -like receptors belonging to the innate immune system. In 1985 he discovered a messenger substance from macrophages with which they react to inflammation and which he called cachectin. Shortly afterwards, he identified this with the then just discovered TNF. He recognized the possibility of using antibodies against TNF to combat septic shock caused by endotoxins in bacterial infections . His discovery of the role of TNF in inflammation is also the basis of corresponding drug developments for various autoimmune diseases.

In 2011 he was awarded the Nobel Prize in Physiology or Medicine together with Jules Hoffmann and Ralph M. Steinman . Beutler's and Hoffmann's discoveries about the activation of innate immunity were recognized.

Awards (selection)

Publications (selection)

  • A. Poltorak, X. He, I. Smirnova, MY Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, B. Beutler: Defective LPS signaling in C3H / HeJ and C57BL / 10ScCr mice: mutations in Tlr4 gene. In: Science . Volume 282, Number 5396, December 1998, pp. 2085-2088, ISSN  0036-8075 . PMID 9851930 .
  • B. Beutler, Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du, K. Hoebe: Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. In: Annual review of immunology . Volume 24, 2006, pp. 353-389, ISSN  0732-0582 . doi : 10.1146 / annurev.immunol.24.021605.090552 . PMID 16551253 . (Review).

Web links

Commons : Bruce Beutler  - Collection of pictures, videos and audio files

Individual evidence

  1. ↑ Biography
  2. ↑ a b Infection-research.de: Have you ever met Prof. Dr. Bruce A. Beutler?
  3. ^ Beutler elected to the American Academy of Arts and Sciences
  4. ↑ University of Texas Southwestern Medical: UT Southwestern scientist shares 2011 Nobel Prize in Physiology or Medicine ( Memento of the original from November 4, 2011 in the Internet Archive ) Info: The archive link was automatically inserted and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. . October 3, 2011. @1@ 2Template: Webachiv / IABot / www.utsouthwestern.edu
  5. ↑ ESI Special Topics: Interview with Dr. Bruce Beutler ( Memento of the original from October 4, 2008 in the Internet Archive ) Info: The @1@ 2Template: Webachiv / IABot / esi-topics.com archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. , July 2007.
  6. ↑ a b The Nobel Prize in Physiology or Medicine 2011 at nobelprize.org, October 3, 2011 (English; accessed October 3, 2011).
  7. ^ American Federation for Clinical Research: Outstanding Investigator Award Recipients
  8. ↑ How mammals sense infections: the future-oriented genetic analysis of innate immunity - Robert Koch lecture by Prof. Dr. Bruce Alan Beutler on the occasion of the 2004 Robert Koch Prize in Berlin ( Memento of the original from November 4, 2005 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.  @1@ 2Template: Webachiv / IABot / www.robert-koch-stiftung.de
  9. ^ William B. Coley Award. In: cancerresearch.org. Retrieved January 24, 2016 .
  10. ^ Prix ​​Charles-Léopold Mayer. List of award winners (PDF, 1.8 MB, status 2014) at academie-sciences.fr; accessed on February 1, 2016.
  11. ↑ 2007 Balzan Prize for Innate ImmunityBruce Beutler and Jules Hoffmann ( Memento of the original from August 30, 2012 on WebCite ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice.  @1@ 2Template: Webachiv / IABot / www.balzan.org
  12. ↑ a b Homepage Bruce Beutler, MD ( Memento of the original from October 5, 2011 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. , Scripps Research Institute @1@ 2Template: Webachiv / IABot / www.scripps.edu
  13. ↑ The FB Bang Award ( Memento of the original from February 7, 2012 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. , Endotoxin Newsletter, Volume 17, Number 3, Fall 2007 (PDF file; 697 kB).  @1@ 2Template: Webachiv / IABot / www.ieiis.org
  14. ^ American Society of Hematology: Albany Medical Center Prize Awarded to Bruce Beutler and Ralph Steinman , July 1, 2009.
  15. ^ The Shaw Prize in Life Science and Medicine 2011 at shawprize.org; Retrieved June 8, 2011
  16. ↑ Member entry by Prof. Dr. Bruce Beutler (with picture and CV) at the German Academy of Sciences Leopoldina , accessed on June 29, 2016.
personal data
SURNAME Beutler, Bruce
ALTERNATIVE NAMES Beutler, Bruce Alan (full name)
BRIEF DESCRIPTION American immunologist and geneticist
DATE OF BIRTH December 29, 1957
PLACE OF BIRTH Chicago