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'''Chemokine (C motif) ligand 2''' (XCL2) is a small [[cytokine]] belonging to the XC [[chemokine]] family that is highly related to another chemokine called [[XCL1]].<ref>{{cite journal |vauthors=Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A |title=Molecular cloning and functional characterization of human lymphotactin |journal=J Immunol |volume=155 |issue=1 |pages=203–9 |year=1995 |pmid=7602097}}</ref> It is predominantly expressed in activated [[T cell]]s, but can also be found at low levels in unstimulated cells. XCL2 induces [[chemotaxis]] of cells expressing the [[chemokine receptor]] [[XCR1]].<ref>{{cite journal |vauthors=Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O |title=Identification of single C motif-1/lymphotactin receptor XCR1 |journal=J Biol Chem |volume=273 |issue=26 |pages=16551–4 |year=1998 |pmid=9632725 |doi=10.1074/jbc.273.26.16551}}</ref> Its [[gene]] is located on [[chromosome 1]] in humans.<ref>{{cite journal |vauthors=Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O |title=Structure and expression of two highly related genes encoding SCM-1/human lymphotactin |journal=FEBS Lett |volume=395 |issue=1 |pages=82–8 |year=1996 |pmid=8849694 |doi=10.1016/0014-5793(96)01004-6}}</ref> |
'''Chemokine (C motif) ligand 2''' (XCL2) is a small [[cytokine]] belonging to the XC [[chemokine]] family that is highly related to another chemokine called [[XCL1]].<ref>{{cite journal |vauthors=Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A |title=Molecular cloning and functional characterization of human lymphotactin |journal=J Immunol |volume=155 |issue=1 |pages=203–9 |year=1995 |pmid=7602097}}</ref> It is predominantly expressed in activated [[T cell]]s, but can also be found at low levels in unstimulated cells. XCL2 induces [[chemotaxis]] of cells expressing the [[chemokine receptor]] [[XCR1]].<ref>{{cite journal |vauthors=Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O |title=Identification of single C motif-1/lymphotactin receptor XCR1 |journal=J Biol Chem |volume=273 |issue=26 |pages=16551–4 |year=1998 |pmid=9632725 |doi=10.1074/jbc.273.26.16551|doi-access=free }}</ref> Its [[gene]] is located on [[chromosome 1]] in humans.<ref>{{cite journal |vauthors=Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O |title=Structure and expression of two highly related genes encoding SCM-1/human lymphotactin |journal=FEBS Lett |volume=395 |issue=1 |pages=82–8 |year=1996 |pmid=8849694 |doi=10.1016/0014-5793(96)01004-6}}</ref> |
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==References== |
==References== |
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Revision as of 11:36, 14 April 2020
| chemokine (C motif) ligand 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | XCL2 | ||||||
| Alt. symbols | SCYC2, SCM-1b | ||||||
| NCBI gene | 6846 | ||||||
| HGNC | 10646 | ||||||
| OMIM | 604828 | ||||||
| RefSeq | NM_003175 | ||||||
| UniProt | Q9UBD3 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q24.2 | ||||||
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Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1.[1] It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.[2] Its gene is located on chromosome 1 in humans.[3]
References
- ^ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol. 155 (1): 203–9. PMID 7602097.
- ^ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
- ^ Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett. 395 (1): 82–8. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.