Irwin Rose
Irwin Allan Rose (born July 16, 1926 in Brooklyn , New York , † June 2, 2015 in Deerfield , Massachusetts ) was an American biochemist and Nobel laureate in chemistry.
Rose was born into a secular Jewish family. He was the son of Ella (Greenwald), who came from a Hungarian-Jewish family, and Harry Royze, who was of Russian-Jewish origin.
Rose graduated from the University of Chicago with a bachelor's degree in 1949 and a Ph.D. in biochemistry in 1952. As a post-doctoral student , he was at Western Reserve University and New York University with Severo Ochoa . In 1953 he became an instructor and later an associate professor at Yale University and in 1963 a professor at the University of Pennsylvania (Fox Chase Cancer Center and Faculty of Biochemistry). From 1976 until his retirement in 1998 he was in the Department of Physiology and Biophysics of the College of Medicine at the University of California at Irvine .
In 2004 he was awarded the Nobel Prize in Chemistry for the discovery of ubiquitin -controlled protein - degradation , along with Aaron Ciechanover and Avram Hershko . With these he clarified the mechanism of the breakdown of superfluous proteins in cells in the late 1970s and early 1980s. These are marked with ubiquitin and broken down in the proteasomes .
In 1972 he was a Guggenheim Fellow in Oxford and at the Hebrew University in Jerusalem.
He was elected a member of the American Academy of Arts and Sciences in 1977, a member of the National Academy of Sciences in 1979, and is a member of the American Association for the Advancement of Science .
literature
- Keith Wilkinson: Irwin Allan Rose (1926-2015). In: Nature . Volume 523, No. 7562, 2015, p. 532, doi: 10.1038 / 523532a
- Arthur L. Haas and Keith Wilkinson: Irwin (Ernie) Allen Rose (1926-2015). In: Cell . Volume 162, No. 2, 2015, pp. 235-236, doi: 10.1016 / j.cell.2015.06.066
Web links
- Information from the Nobel Foundation on the 2004 award ceremony for Irwin Rose
Individual evidence
- ↑ American Nobel Laureate Irwin Rose dies ( Memento of the original from July 26, 2015 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.
- ^ Nobelprize.org - Irwin Rose Autobiography
- ↑ Career data according to Pamela Kalte u. a. American Men and Women of Science , Thomson Gale 2004
| personal data | |
|---|---|
| SURNAME | Rose, Irwin |
| ALTERNATIVE NAMES | Rose, Irwin A .; Rose, Irwin Allan (full name) |
| BRIEF DESCRIPTION | American biochemist and Nobel Prize winner in chemistry |
| DATE OF BIRTH | July 16, 1926 |
| PLACE OF BIRTH | Brooklyn , New York |
| DATE OF DEATH | 2nd June 2015 |
| Place of death | Deerfield , Massachusetts |